Comparative Evaluation of Various Tests for Diagnosis of Concurrent Malaria and Typhoid Fever in a Tertiary Care Hospital of Northern India

Verma, Deepika; Kishore, Sachin; Siddique, M E

doi:10.7860/jcdr/2014/7745.4403

Cited by 11 publications

(16 citation statements)

References 3 publications

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“…In a similar study conducted in 2014, a co-infection rate of 1.6% for malaria and typhoid was observed. 8 Furthermore, a co-infection rate of 6.7% (20/300) was observed in our study using Widal test for typhoid and peripheral blood smear for malaria. A study from Ethiopia reported coinfection rate of 6.5% using Widal test and 0.5% with blood culture, which is in accordance to our study.…”

Section: Discussionsupporting

confidence: 47%

Incidence of Co-infection of Malaria and Typhoid and their Diagnostic Dilemmas

Vats¹,

Anand²

2018

RAPL

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Background: This study was carried out to know the incidence of co-existence of typhoid and malaria in western part of Uttar Pradesh. Both these infections are common febrile illnesses prevalent in tropical countries including India. Materials and Methods:A total of 300 blood samples were collected from the patients presenting with fever for more than one week. Diagnosis of typhoid was carried out using Widal test and blood culture and for diagnosis of malaria blood film examination was done.Results: Out of total 300 patients, 31 (10.3%) were positive for malarial parasite and 82 (27.3%) were positive for typhoid by Widal test while 12 (4%) were positive for typhoid by blood culture. Rate of co-infection was found out to be 21 (6.7%) with Widal test and 3 (1%) with blood culture. Conclusion:As there is paucity of data on co-infection of malaria and typhoid from this part of country, this study was carried out to know their prevalence. As both these illnesses present with same clinical features, the clinicians must look for co-existence of these infections. Hence, to facilitate the diagnosis and treatment more such studies must be carried out from different parts of the country.

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Section: Discussionsupporting

confidence: 47%

Incidence of Co-infection of Malaria and Typhoid and their Diagnostic Dilemmas

Vats¹,

Anand²

2018

RAPL

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“…There is high prevalence of typhoid fever from Widal test when compared to stool culture according to the present study. This finding was in conformity with the findings of Wam et al, [18]; Gemechu et al, [19] and Verma et al, [20]. The high Widal prevalence in the present study could be associated with cross-reacting antibodies from febrile patients other than typhoid fever [18].…”

Section: Discussionsupporting

confidence: 94%

“…The result is lower than that of Gemechu et al, [19], which showed a high prevalence of typhoid fever (20%) using stool culture and 68.4% using Widal test method in Ethiopia. On the other hand, this result is lower than that of Verma et al, [20] in Northern India who found prevalence rate of 10.8% and 3.3% for Widal test and stool culture respectively. Low prevalence rate of typhoid fever among febrile patients in this study is attributed to high malaria prevalence in the area.…”

Section: Discussioncontrasting

confidence: 76%

Comparative Study of Widal test Against Stool Culture in Diagnosis of Typhoid Fever Suspected Cases in Kano, Northern Nigeria

Minjibir¹,

Diso²,

Ibrahim³

et al. 2020

SARJET

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“…Our results were in concordance with those of the studies which were reported by some researchers in other endemic states of India. [24][25][26][27] For the anti-TH antibodies, an agglutinin titre of up-to 1:60 was discovered in the apparently healthy study population, whereas for the anti-TO antibodies, our result was lower (a titre of 1:40), which was in contrast to the reports of some other workers but it was in accordance with the reports of some previous studies. Several factors may have contributed to this discrepancy, because the differences in the antibody response may be due to the poorly standardized antigen preparation and the sharing of the antigen determinants with other Salmonellae.…”

Section: Discussionsupporting

confidence: 91%

Determination of Significant Baseline Widal Titre amongst Health Personnel & General Population of Ajmer City

Mohanpuria¹,

Sharma²,

Kamble³

et al. 2016

IJMRP

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Background: Enteric Fever is the most infectious disease on global scale and endemic in all parts of India. In a developing country like India laboratory diagnosis of enteric fever relies heavily on serological tests such as widal test. Knowledge of prevalent endemic titre in a region needs to be periodically updated to interpret the significance of the titre as to patient is indeed suffering from enteric fever or not. The present study has been undertaken to evaluate the baseline antibody titre for O, H antigens of Salmonella Enterica, serovar Typhi and AH, BH antigen of Salmonella Enterica, serovar Paratyphi among health personnel and general adult population of Ajmer (Rajasthan). Aim and objectives: To evaluate the significant endemic baseline titre of Ajmer city using quantitative Widal test to suggest the cut off value for interpreting a positive widal test. To compare the endemic baseline titre amongst the Health care providers and General Population. Material and methods: A total number of 600 healthy volunteers and 200 medical personnel working in Jawahar Lal Nehru Medical College, Ajmer were screened during period of study from 1 st April 2014 to 31 st December 2015. Non repetitive samples were collected from healthy adults aged 18 year to 70 year. Results and conclusions: Out of 600 screened samples for healthy volunteers 61% were males and 39% were females. The frequency of positive results was 43.67%. The agglutinins to S. Typhi were the most prevalent among the sera of various dilutions (33.16% for 'O' antigen and 43.33% for 'H' antigen) which was tested. The levels of agglutinins for Salmonella paratyphi AH and paratyphi BH were low (only 1.16% for AH and 1.83% for BH antigen respectively).Out of 200 samples of health personnel screened 69% were males and 31% were females. The frequency of positive results was 45.5%. The agglutinins to S. Typhi were the most prevalent among the sera of various dilutions (33.16% for 'O' antigen and 44.5% for 'H' antigen) which were tested. The levels of agglutinins for Salmonella paratyphi AH and paratyphi BH were low (only 4.0% for AH and 1.5% for BH antigen respectively). Based on the above results, it has been recommended that cutoff titre of 1:80 for anti-O antibodies and of 1:120 for the anti-H antibodies may be considered as diagnostic for enteric fever in Ajmer region of Rajasthan, India.

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Comparative Evaluation of Various Tests for Diagnosis of Concurrent Malaria and Typhoid Fever in a Tertiary Care Hospital of Northern India

Cited by 11 publications

References 3 publications

Incidence of Co-infection of Malaria and Typhoid and their Diagnostic Dilemmas

Incidence of Co-infection of Malaria and Typhoid and their Diagnostic Dilemmas

Comparative Study of Widal test Against Stool Culture in Diagnosis of Typhoid Fever Suspected Cases in Kano, Northern Nigeria

Determination of Significant Baseline Widal Titre amongst Health Personnel & General Population of Ajmer City

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