Comparative Evaluation of the Use of the Immobilized Form of Hexetidine, Photoditazine and Their Combination in the Treatment of Purulent Wounds

Abstract

Treatment of purulent wounds is an urgent problem in modern surgery. The need to develop new combinations that improve the treatment process is one of the priorities. Materials and methods. A purulent wound model was formed on 180 Wistar rats divided into 5 equal groups. The percentage of reduction of the wound area, healing rate, microbial contamination were evaluated, histological examination was performed. Results. In groups with the use of a photosensitizer, complete wound healing occurred by 15 days. The maximum healing rate of the combined use of hexethidine and photoditazine occurred in the first phase of the wound process, and microbial contamination by the 10th day was less than 15 thousand times compared to the control, and 187,5 times – with the comparison group (p < 0,05). Conclusions. The developed combinations have a positive effect on the course of the wound process, accelerating wound healing and reducing microbial contamination.