Comparative evaluation of the immunogenicity of yeast‐derived (recombinant) and plasma‐derived hepatitis B vaccine in infants

Abstract

The immunogenicity of plasma-derived (HB Vax,MSD) and recombinant hepatitis B virus (Engerix B, SK&F) vaccines was evaluated in infants born to hepatitis B virus carrier mothers. The vaccination was carried out at 1 day, 1 month, and 6 months of age using 10 micrograms of the vaccine given intramuscularly. A total of 83/88 (94.3%) and 74/79 (93.6%) of the infants receiving the plasma-derived vaccine and yeast-derived vaccine showed antibody to hepatitis B surface antigen (anti-HBs). None of the maternal factors studied apart from the HBeAg positivity corellated with vaccine failure. The yeast-derived vaccine gives marginally lower antibody titre than the plasma-derived vaccine. The group-specific anti-"a" antibody was less than 10% of the total anti-HBsAg titre. It was observed that the vaccine alone without prior administration of hepatitis B immunoglobulin is effective in perinatal infection.

Seroprevalence of hepatitis B infection during pregnancy and risk of perinatal transmission

“…HBeAg positivity rate among HBsAg positive antenatal women have been shown to vary widely in different geographical regions around the world [22,[24][25][26][27][28][29][30][31][32][33]. HBeAg positivity in our study (57%) was similar to that previously reported in a study by Biswas [23].…”

Study on Hepatitis B Virus Infection in Pregnant Women and its Risk Factors

“…Preterm delivery is a common maternal complication of hepatits in pregnancy and is observed in the following studies with rates: Caesarean section rate in our study is 33.5% which is comparable to that done by Suruchi Shukla 16 , where it was 29.7%. Maternal complications rate encountered in present study is nearly similar to that seen in general population Studies 6.3% Sunita Mittal et al, 5 6.3% Gill et al, 6 5% Ahmad et al, 7 12.8% Biswas et al, 8 2.3% Panda et al, 9 2.6% Sehgal et al 10 , 2.6% Mean age in years Sabria Rashid et al 12 28.5 years. Suruchi Shukla et al 13 23.85 years Present study 23.61 years Percentage of subjects in 3 rd trimester Jaisiwal et al 14 72% Patra et al 15 72% Suruchi Shukla et al 16 75% Present Study 50.4% Preterm labour percentage Suruchi Shukla et al 16 17% Medhat et al .…”

Higher disappearance rate of anti‐HBs in Taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis B vaccine

“…However, the anti-HBs GMT of the PDHBV was higher (P<.05) than that elicited by RYHBV. Panda et al 32 evaluated immunogenicity of PDHBV and RYHBV in infants born to hepatitis B virus carrier mothers. The RYHBV gives marginally lower antibody titre than the PDHBV.…”