Comparative evaluation of surface-modified zirconia for the growth of bone cells and early osseointegration

Majhi, Rashmita; Majhi, Rakesh Kumar; Garhnayak, Lokanath; Patro, Tapan Kumar; Dhal, Angurbala; Kumar, Satish; Guha, Puspendu; Goswami, Luna; Goswami, Chandan

doi:10.1016/j.prosdent.2021.04.014

“…(57) and Freitas et al (38) reported that increasing KVp would decrease the amount of HDMs artifacts in CBCT images. Moreover, Gaêta-Araujo et al (54) reported that increasing the tube current would have the same effect. In the current study, 90 KVp and 14 mA, the highest kilovoltage and tube current available in the machine, were used to ensure the best exposure settings were utilized and that the only factor that might interfere with the radiographic diagnosis of simulated perforation would be the artifacts produced by adjacent Ti implants.…”

Section: Discussionmentioning

confidence: 91%

“…Similarly, Baltacioĝlu et al (53) covered the dry skull and mandible with 2-cm red wax as a soft-tissue equivalent material during CBCT scanning to detect recurrent caries. Titanium implants were used because titanium is one of the most commonly used dental implant materials (54) . In our daily practice, there is a high probability of seeing patients with one or more titanium implants in their oral cavities.…”

Section: Discussionmentioning

confidence: 99%

Detection of simulated root perforation in the vicinity of titanium implant using CBCT

Elramah,

Bayoumy,

Abo Khalaf

2023

Egyptian Dental Journal

0

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Objectives: to evaluate the influence of the metal artifact reduction algorithm (MAR) on detecting root perforation adjacent to titanium implant using CBCT. Materials and methods:This observational analytical ex vivo study was conducted on 56 human teeth. Two titanium implants were inserted in a dry human mandible at the site of the lower right and left first premolars. Then, decoronated single-rooted endodontically cleaned and shaped teeth were placed in the sockets adjacent to the implants. Of the 56 teeth, 28 were without perforation (control group), and 28 had simulated root perforations. CBCT scans were obtained without and with a metal artifact reduction filter and assessed by two dental radiologists and one general practitioner. Results were statistically analyzed in terms of accuracy, specificity, and sensitivity in addition to Kendall's coefficient of concordance and receiver operator characteristic (ROC) curve analysis.Results: There was a significant difference between the results of acquisitions without and with the metal artifact reduction algorithm (MAR). Acquisitions without MAR had higher values; accuracy (91.1%) and sensitivity (92.9%). In contrast, acquisitions with MAR had lower values; accuracy (71.4%) and sensitivity (50%). Conclusion:The metal artifact reduction algorithm hinders diagnosing lateral root perforation adjacent to titanium implants.

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“…25 The surface pattern can be altered by acid etching and airborne particle abrasion, or the surface's physiochemical characteristics can be altered through coating application to enhance the surface's bioactive and osteoconductive qualities. 26 Meanwhile, MSCs are capable of self-renewal and cell lineage differentiation into a wide range of cell types, including osteoblasts, chondrocytes, adipocytes, neuroblasts, and myoblasts. hPDLSCs have been used in this study for the advantages of MSCs as self-renewal, multipotency and immunomodulation, in addition to being a cell population that is conveniently accessible and has the required properties for future clinical use in human studies.…”

Section: Discussionmentioning

confidence: 99%

Enhanced human periodontal ligament stem cell viability and osteogenic differentiation on two implant materials: An experimental in vitro study

Shafei

¹

,

Raafat

²

,

Farag

³

2023

F1000Res

1

0

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Background: Surface roughness of dental implants impacts the survival of adult periodontal stem cells and rate of differentiation. This research was conducted to test how human periodontal ligament stem cells behaved on yttria stabilized tetragonal zirconia polycrystals and polyetheretherketone (PEEK) discs with different surface topographies. Methods: Discs roughening was prepared by sandblasting. Stem cells were cultivated on zirconia discs with a polished surface, PEEK discs with a polished surface, sandblasted zirconia discs and sandblasted PEEK discs. Cells viability was assessed after 24, 48, 72 hours. Scanning electron microscopy was used to examine the adherence and attachment of cells. Osteoblastic differentiation capacity was studied by checking the mineralization clusters development through alizarin red S staining and alkaline phosphatase assay. ANOVA and the Tukey post hoc test were used for the statistical analysis. Results: Polished PEEK discs showed lower cell viability, whereas roughened sandblasted zirconia and PEEK discs showed the highest proliferation rates and cell viability percent. The osteogenic differentiation was enhanced for rough surfaces in comparison to polished surfaces. Sandblasted zirconia and PEEK discs showed a markedly increased mineralized nodule development and ALP enzyme activity compared to the polished surface and control. Conclusions: Micro- topographies creation on the PEEK implant surface enhances stem cell attachment, viability, and osteogenic differentiation.

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“… 25 The surface pattern can be altered by acid etching and airborne particle abrasion, or the surface's physiochemical characteristics can be altered through coating application to enhance the surface's bioactive and osteoconductive qualities. 26 …”

Section: Discussionmentioning

confidence: 99%

Enhanced human periodontal ligament stem cell viability and osteogenic differentiation on two implant materials: An experimental in vitro study

Shafei

¹

,

Raafat

²

,

Farag

³

2023

F1000Res

0

View full text Add to dashboard Cite

Background: Surface roughness of dental implants impacts the survival of adult periodontal stem cells and rate of differentiation. This research was conducted to test how human periodontal ligament stem cells behaved on yttria stabilized tetragonal zirconia polycrystals and polyetheretherketone (PEEK) discs with different surface topographies. Methods: Discs roughening was prepared by sandblasting. Stem cells were cultivated on zirconia discs with a polished surface, PEEK discs with a polished surface, sandblasted zirconia discs and sandblasted PEEK discs. Cells viability was assessed after 24, 48, 72 hours. Scanning electron microscopy was used to examine the adherence and attachment of cells. Osteoblastic differentiation capacity was studied by checking the mineralization clusters development through alizarin red S staining and alkaline phosphatase assay. ANOVA and the Tukey post hoc test were used for the statistical analysis. Results: Polished PEEK discs showed lower cell viability, whereas roughened sandblasted zirconia and PEEK discs showed the highest proliferation rates and cell viability percent. The osteogenic differentiation was enhanced for rough surfaces in comparison to polished surfaces. Sandblasted zirconia and PEEK discs showed a markedly increased mineralized nodule development and ALP enzyme activity compared to the polished surface and control. Conclusions: Micro- topographies creation on the PEEK implant surface enhances stem cell attachment, viability, and osteogenic differentiation.

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Comparative evaluation of surface-modified zirconia for the growth of bone cells and early osseointegration

Cited by 8 publications

References 25 publications

Detection of simulated root perforation in the vicinity of titanium implant using CBCT

Detection of simulated root perforation in the vicinity of titanium implant using CBCT

Enhanced human periodontal ligament stem cell viability and osteogenic differentiation on two implant materials: An experimental in vitro study

Enhanced human periodontal ligament stem cell viability and osteogenic differentiation on two implant materials: An experimental in vitro study

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