Comparative Evaluation of^99mTc GH,^99mTcO₄, and^99mTc DTPA as Brain Imaging Agents

Abstract

The brain imaging properties of 99mTc glucoheptonate, 99mTc pertechnetate, and 99mTc DPTA are compared. Results demonstrate that optimum images are obtained at 90, 180, and 180 min., for 99mTc GH, 99mTc DTPA, and 99mTc perterchnetate, respectively. The former two images are not affected by prior bone imaging with 99mTc pyrophosphate, while 99mTc pertechnetate images are adversely affected. 99mTc glucoheptonate appears to be the superior agent for brain imaging, followed by 99mTc DTPA and 99mTc pertechnetate.

Use of 99m-technetium-glucoheptonate as a tracer for brain tumor imaging: An overview of its strengths and pitfalls

“…In a comprehensive study comparing 99mTc-GHA with 99mTc-pertechnetate and 99mTc-diethylenetriamine penta-acetic acid as brain-scanning agents, they concluded that 99mTc-GHA was the radiotracer of choice for detection of central nervous system abnormalities. [ 31 ] Léveillé et al ., in their study also demonstrated the superiority of 99mTc-GHA over 99mTc-pertechnetate for the detection of CNS tumors. In addition, they concluded that compared with early brain scans, delayed studies frequently provided improved lesion detection, and they observed progressive accumulation of 99mTc-GHA in primary and metastatic brain tumor at 4 h and even up to 9 h after injection.…”