Comparative Evaluation of Specific Vaccines and Immuno‐Modulators in Disease Control of Beef Cattle

Berneri, C.; Amadori, Massimo; Ceccarelli, Adriano; Guadagnini, P. F.; Bolzani, E.

doi:10.1111/j.1439-0450.1991.tb00847.x

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…There are antigenic and structural similarities among a IFN, ACTH and endorphins (BLALOCK and SMITH, 1980); both noradrenaline and ACTH can induce an anti-viral state, a I F N exerting corresponding hormonal activities on the same cells in culture (SMITH and BLALOCK, 1988). It might be of relevance that IFN, o r IFN-like molecules, possibly hormones, can be detected in blood samples of calves and pigs after acute transportation stress (ARTURSSON et al, 1989;BERNERI et al, 1991); these molecules could be induced as part of ongoing viral infections, or be involved in a general homeostatic response to environmental conditions. Most important, a IFN and a IFN-like proteins were shown to participate in different homeostatic processes: such responses are typified by the secretion of bovine TP-1, a fundamental anti-luteolytic signal of the conceptus (PLANTE et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, interesting results were obtained in trials of IFN and IFN BERNERI et al, 1991). Among the main types of I F N molecules (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Sera from the first and second samplings were not tested Lymphocyte stimulation test (c.p.m.). The blast response of peripheral blood lymphocytes to Concanavallin A was assessed as previously described (BERNERI et al, 1991). Results are expressed as counts per minute (c.p.m.…”

mentioning

confidence: 99%

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Disease Resistance and Thriftiness of Calves given Human Lymphoblastoid Interferon

Amadori

Archetti

Berneri

et al. 1994

Journal of Veterinary Medicine, Series B

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A field trial was set up to evaluate the effect of human lymphoblastoid interferon (IFN) as a biological response modifier (BRM) in cattle. Two different doses (100 and 1000 International Units /kg body weight) of partially purified interferon from Namalwa cells were administered to suckling calves, after animals were introduced into a large veal fattening and finishing unit. The clinical conditions of the calves and some parameters of specific and non-specific immunity, along with the individual weights, were evaluated over a 4-month period. The higher IFN dose correlated with a favourable clinical response of calves to a respiratory syndrome; this was further substantiated by a dramatic improvement of the growth rate with respect to control calves. To a lesser extent, this also occurred in calves given the lower IFN dose. These results suggest better disease resistance in IFN-treated calves, possible associated with dose-dependent regulation of basic homeostatic functions.

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Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, interesting results were obtained in trials of IFN and IFN BERNERI et al, 1991). Among the main types of I F N molecules (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Disease Resistance and Thriftiness of Calves given Human Lymphoblastoid Interferon

Amadori

Archetti

Berneri

et al. 1994

Journal of Veterinary Medicine, Series B

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“…Os autores detectaram que a lisozima só está presente nas lágrimas de cabras e ovelhas, e não de bezerros. Já Berneri et al (1991) usaram a técnica para comparação da evolução de vacinas específicas de imunomoduladores no controle de doenças de bezerros de corte. Riedel e Schmidit (1991), estudando a influência de leucócitos no colostro no sistema imune de bezerros neonatos, utilizaram a técnica de dosagem de lisozima e provaram a presença da enzima no colostro.…”

Section: Introdução E Literaturaunclassified

Dosagem de lisozima para avaliação da resposta imune em bezerros

García

Chate

Porto

et al. 2005

RBCV

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ResumoO presente trabalho visou verificar a eficiência da dosagem de lisozima como indicador de imunidade em bovinos, valendo-se de animais naturalmente acometidos de processo diarréico. Para tanto, foram utilizados bezerros com até três meses de idade, criados em manejo semi-intensivo e divididos em três grupos experimentais (I -sem diarréia, II -com diarréia mas sem sintomas sistêmicos, III -com diarréia e sintomas sistêmicos). Foram colhidas amostras sangüíneas de cada animal, que foram processadas para a realização da dosagem de gamaglobulinas por eletroforese, dosagem de IgG por imunodifusão radial, contagem de linfócitos e dosagem de lisozima. Os resultados encontrados mostraram existir linfopenia nos animais do grupo III, mas não foi verificada hipogamaglobulinemia na eletroforese ou na imunodifusão radial. Não foram encontradas diferenças estatisticamente significantes no nível de lisozima entre os grupos estudados. Não foi possível demonstrar correlação entre a dosagem de lisozima e os outros indicadores preconizados no presente experimento. Todavia, embora no presente experimento não se tenha encontrado uma correlação positiva entre o teor de lisozima e parâmetros de resposta imunitária, os resultados obtidos sugerem que novos trabalhos devam ser realizados para que tal parâmetro seja validado como indicador biológico.Palavras-chave: lisozima, resposta imune, bezerros. AbstractThe purpose of this work was to evaluate the serum lysozyme concentration as an indicator of immune response in bovine, considering naturally affected animals with diarrheic process. The experiment was conducted using 3 months old calves, raised in semi-intensive system and allocated into 3 groups with 10 animals each one (I -no diarrhea, II -diarrhea but no systemic symptoms, III -diarrhea and systemic symptoms). Blood samples were collected from each animal and processed by electrophoresis to verify the gamma-globulin content. The IgG was measured by radial immunodiffusion. Other measurements included blood lymphocyte count and serum lysozyme concentration. The results showed lymphopenia in animals of group III, but no differences were found in gamma-globulin content, as measured by electrophoresis and radial immunodiffusion. No differences were found in the lysozyme content in all groups analyzed and it was not possible to demonstrate a correlation between the lysozime content and the other indicators studied in this experiment. However, although it was not found this positive correlation, the results suggest that new works have to be performed to validate this parameter as a biological indicator.

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Role of a Distinct Population of Bovine γδ T Cells in the Immune Response to Viral Agents

Amadori¹,

Archetti²,

Verardi³

et al. 1995

Viral Immunology

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A distinct population of bovine gamma delta T cells was isolated from peripheral blood mononuclear cells of foot-and-mouth disease (FMD)-vaccinated cattle; these lymphocytes were shown to exert a natural killer-like activity against cells infected by different viruses. The antiviral activity was dependent upon cognate recognition of target cells and could operate by both cytostatic and cytotoxic mechanisms. Among these, secretion of a serine esterase was shown after binding to target cells. This population of bovine gamma delta T cells is recognized by murine monoclonal antibodies 1E7, 5D4, and 6F9, raised in our laboratory. To define an in vivo antiviral role, four heifers were infected with a strain of bovid herpesvirus 1 by the intranasal/intravaginal routes and contact exposure. The prevalence of 1E7+/5D4+ cells among peripheral blood lymphocytes increased dramatically in the first days after infection; the same held true for in-contact cattle, albeit with a different time kinetics. In another experiment, colonization of mucosae was demonstrated by immunoperoxidase staining on tongue and palate sections of healthy cattle. The infiltration of gamma delta T cells altogether in the palate mucosa was much more accentuated in foot-and-mouth disease-vaccinated, as compared to nonvaccinated, control calves.

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Comparative Evaluation of Specific Vaccines and Immuno‐Modulators in Disease Control of Beef Cattle

Cited by 4 publications

References 18 publications

Disease Resistance and Thriftiness of Calves given Human Lymphoblastoid Interferon

Disease Resistance and Thriftiness of Calves given Human Lymphoblastoid Interferon

Dosagem de lisozima para avaliação da resposta imune em bezerros

Role of a Distinct Population of Bovine γδ T Cells in the Immune Response to Viral Agents

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