Comparative evaluation of severity of COVID-19 pneumonia on computed tomography of the chest in vaccinated and non-vaccinated individuals: an observational study

Mahajan, Manik; Gupta, Vikrant; Ilyas, Mohd; Gupta, Kulbhushan; Singh, Parveen

doi:10.5114/pjr.2022.116192

Cited by 4 publications

(7 citation statements)

References 26 publications

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“…COVID-19 was mild in the vaccinated group compared to unvaccinated group. Covishield vaccine administration reduces the severity of COVID-19 pneumonia as compared to the nonvaccinated group, with a marked reduction in mortality (5) . Prior COVID-19 was associated with protection against any recurrent COVID-19 infection, against hospitalization and also against COVID-19 not requiring hospitalization (8) .…”

Section: Discussionmentioning

confidence: 95%

“…After a mean interval of 5 days CT-chest has sensitivity of 97% in the diagnosis of COVID-19 pneumonia. CT-chest findings that are classically seen in COVID-19 pneumonia include ground glass opacities with bilateral, peripheral, and basal predominance with or without consolidation (5) . It was also noted that blood group of individual plays a role in immunopathogenesis of COVID 19 infection, individuals with blood group ' A' were higher susceptibility to infection and propensity to severe disease compared to group 'O' individuals less likely (6) .…”

Section: Intorudctionmentioning

confidence: 99%

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A Comparative Study of Severity of Covid-19 Infection & their Radiological Findings in Vaccinated and Unvaccinated Individuals

Moogaambiga¹,

Pranay²,

Kirubhakaran³

et al. 2022

IJST

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Objectives: To compare the severity of COVID-19 infection and their radiological findings between vaccinated and unvaccinated individuals. Also, to investigate if any difference of severity of infection exists between patients with blood group 'A' and with blood group 'O'. Methods: This study has 302 patients which include both vaccinated and unvaccinated individuals. Both the group of patients were subjected to Computed tomography-Chest imaging and the severity of COVID-19 infection was analyzed between both the groups using CT-Severity score (CT-SS). Findings: In 302 study population, 91% of patients are unvaccinated and remaining 9% are vaccinated. Among these patients, 273 were having CORADS-5 which constitute 90% of population. Mortality among unvaccinated people was 17.2% compared to vaccinated people having mortality rate of 3.4% which was significant. Individuals with Blood group 'A' were highly infected and individuals with group 'O' were least affected compared to individuals with other blood groups among unvaccinated individuals. Novelty: Increased mortality was seen among unvaccinated individuals(17.2%)compared to vaccinated patients(3.4%). CT-Severity score was lower among vaccinated patients compared to unvaccinated patients. This study also compared the severity of the infection in individuals with various ABO blood groups among unvaccinated patients which showed that there was a significant effect on blood groups on severity of infection.

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Section: Discussionmentioning

confidence: 95%

Section: Intorudctionmentioning

confidence: 99%

A Comparative Study of Severity of Covid-19 Infection & their Radiological Findings in Vaccinated and Unvaccinated Individuals

Moogaambiga¹,

Pranay²,

Kirubhakaran³

et al. 2022

IJST

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“…In the study of Sagiraju et al, it was shown that full dose vaccination reduces the risk of severe disease and mortality, regardless of the vaccine type[ 15 ]. In the study of Mahajan et al [ 16 ], where they evaluated vaccinated and unvaccinated patients with a positive SARS-CoV-2 PCR test, they found that the CT-SS of vaccinated people was mild-moderate, while unvaccinated individuals were moderate-severe. Again, in the studies conducted by Russo et al [ 4 ], Ravindra et al [ 5 ], Fatima et al [ 6 ], and Yavuz et al [ 17 ], when the CT SS of vaccinated and unvaccinated patients were compared, it was shown that vaccinated patients had milder pulmonary involvement.…”

Section: Discussionmentioning

confidence: 99%

Effect of vaccination status on CORADS and computed tomography severity score in hospitalized COVID-19 patients: A retrospective study

Binay,

Karavaş,

Karakeçili

et al. 2023

World J Methodol

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BACKGROUND The coronavirus disease 2019 (COVID-19) pandemic is continuing. The disease most commonly affects the lungs. Since the beginning of the pandemic thorax computed tomography (CT) has been an indispensable imaging method for diagnosis and follow-up. The disease is tried to be controlled with vaccines. Vaccination reduces the possibility of a severe course of the disease. AIM The aim of this study is to investigate whether the vaccination status of patients hospitalized due to COVID-19 has an effect on the CT severity score (CT-SS) and CORADS score obtained during hospitalization. METHODS The files of patients hospitalized between April 1, 2021 and April 1, 2022 due to COVID-19 were retrospectively reviewed. A total of 224 patients who were older than 18 years of age, whose vaccination status was accessible, whose severe acute respiratory syndrome coronavirus 2 polymerase chain reaction result was positive, and who had a Thorax CT scan during hospitalization were included in the study. RESULTS Among the patients included in the study, 52.2% were female and the mean age was 61.85 years. The patients applied to the hospital on the average 7th day of their complaints. While 63 patients were unvaccinated (Group 1), 20 were vaccinated with a single dose of CoronaVac (Group 2), 24 with a single dose of BioNTech (Group 3), 38 with 2 doses of CoronaVac (Group 4), 40 with 2 doses of BioNTech (Group 5), and 39 with 3 doses of vaccine (2 doses of CoronaVac followed by a single dose of BioNTech, Group 6). CT-SS ranged from 5 to 23, with a mean of 12.17. CT-SS mean of the groups were determined as 14.17, 13.35, 11.58, 10.87, 11.28, 10.85, respectively. Accordingly, as a result of the comparisons between the groups, the CT-SS levels of the unvaccinated patients found to be significantly higher than the other groups. As the vaccination rates increased, the rate of typical COVID-19 findings on CT was found to be significantly lower. CONCLUSION Increased vaccination rates in COVID-19 patients reduce the probability of typical COVID-19 symptoms in the lungs. It also reduces the risk of severe disease and decreases CT Severity Scores. This may lead to a loss of importance of Thorax CT in the diagnosis of COVID-19 pneumonia as the end of the pandemic approaches.

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“…On the other hand, Lee et al reported results on CT findings limited to a small population of partially (n = 64) or completely vaccinated (n = 22) patients [21]. Furthermore, these studies [19][20][21][22] showed contrasting results regarding the extent of COVID-19 lung involvement depending on the different vaccination statuses.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the extent of pneumonia at the initial CT exam has major prognostic value [18]. Some authors recently described differences in pneumonia rates and CT findings between patients with complete or incomplete vaccination cycle [19][20][21][22]. However, these studies showed evidence limited to a population vaccinated with inactivated virus vaccine BBV152 viz.…”

Section: Introductionmentioning

confidence: 99%

Chest computed tomography of suspected COVID-19 pneumonia in the Emergency Department: comparative analysis between patients with different vaccination status

Carbonaro¹,

Braga²,

Gemma³

et al. 2023

Pol J Radiol

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Purpose: To identify differences in chest computed tomography (CT) of the symptomatic coronavirus disease 2019 (COVID-19) population according to the patients' severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination status (non-vaccinated, vaccinated with incomplete or complete vaccination cycle). Material and methods:CT examinations performed in the Emergency Department (ED) in May-November 2021 for suspected COVID-19 pneumonia with a positive SARS-CoV-2 test were retrospectively included. Personal data were compared for vaccination status. One 13-year experienced radiologist and two 4th-year radiology residents independently evaluated chest CT scans according to CO-RADS and ACR COVID classifications. In possible COVID-19 pneumonia cases, defined as CO-RADS 3 to 5 (ACR indeterminate and typical) by each reader, high involvement CT score (≥ 25%) and CT patterns (presence of ground glass opacities, consolidations, crazy paving areas) were compared for vaccination status.Results: 184 patients with known vaccination status were included in the analysis: 111 non-vaccinated (60%) for SARS-CoV-2 infection, 21 (11%) with an incomplete vaccination cycle, and 52 (28%) with a complete vaccination cycle (6 different vaccine types). Multivariate logistic regression showed that the only factor predicting the absence of pneumonia (CO-RADS 1 and ACR negative cases) for the 3 readers was a complete vaccination cycle (OR = 12.8-13.1 compared to non-vaccinated patients, p ≤ 0.032). Neither CT score nor CT patterns of possible COVID-19 pneumonia showed any statistically significant correlation with vaccination status for the 3 readers.Conclusions: Symptomatic SARS-CoV-2-infected patients with a complete vaccination cycle had much higher odds of showing a negative CT chest examination in ED compared to non-vaccinated patients. Neither CT involvement nor CT patterns of interstitial pneumonia showed differences across different vaccination status.

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Comparative evaluation of severity of COVID-19 pneumonia on computed tomography of the chest in vaccinated and non-vaccinated individuals: an observational study

Cited by 4 publications

References 26 publications

A Comparative Study of Severity of Covid-19 Infection & their Radiological Findings in Vaccinated and Unvaccinated Individuals

A Comparative Study of Severity of Covid-19 Infection & their Radiological Findings in Vaccinated and Unvaccinated Individuals

Effect of vaccination status on CORADS and computed tomography severity score in hospitalized COVID-19 patients: A retrospective study

Chest computed tomography of suspected COVID-19 pneumonia in the Emergency Department: comparative analysis between patients with different vaccination status

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