Comparative evaluation of serum levels of main minerals and postmenopausal osteoporosis

Okyay, Emre; Ertugrul, C.; Acar, Berrin; Şişman, Ali Rιza; Onvural, Banu; Özaksoy, Dinç

doi:10.1016/j.maturitas.2013.07.015

Cited by 51 publications

(33 citation statements)

References 20 publications

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“…First, this study is a retrospective collection of historical data and may have been biased due to improper recall similar to other studies in which data were collected retrospectively [1,3,5,6,12]. Secondly, as it has been also reported among limitations of similar studies in the literature, several other factors such as physical activity, dietary intake of dairy products and factors associated with osteoporosis including history of oral contraceptive pill usage and socioeconomic status were not analyzed [1,5,33]. For these reasons further studies are required to clarify the effect of these confounding factors on the association between short IPI and osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Interpregnancy interval as a risk factor for postmenopausal osteoporosis

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Interpregnancy interval as a risk factor for postmenopausal osteoporosis

et al. 2015

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“…These minerals are usually found low in menopausal women, and this occurs due to ovarian hormone deficiency [38]. These minerals participate in the process of bone maintenance through their catalytic action in the synthesis of the bone matrix [39].…”

Section: Resultsmentioning

confidence: 99%

Rankl Expression and Metabolic Changes in Ovariectomized Rats and the Possible Protection by Vegetable Formula.

Hanafi

2018

Asian J Pharm Clin Res

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Objective: This study was to evaluate complications of osteoporosis in ovariectomized rats and the possibility to ameliorate these changes by consumption of vegetable formula. Furthermore, transcription of mRNA of RANKL gene was matched with bone mass density (BMD) and bone formation marker (human procollagen 1 N terminal peptide [PINP]).Methods: Thirty rats were divided into three groups. The first is non ovariectomized control group (NOVXC), the second is ovariectomized control group (OVXC), and the third is ovariectomized rats supplemented with the vegetable formula (OVXT). Animals were fed for 8 successive weeks. Animals were treated and sacrificed under the recommended ethics of laboratory animal's treatment. The vegetable mixture was formulated with the purpose to correct the bone compromise and supply all the presumed deficient elements and hormone.Results: Chemical analysis showed that the formulated vegetable mixture had a high amount of flavonoids as catechin (100 mg/100 g of dry weight) and polyphenols as tannic acid (1000 mg/100 g dry weight. Furthermore, it had high reducing power (1,1-diphenyl-2-picrylhydrazyl radical showed inhibition percentage of 91.81%.). Several phytochemicals necessary for bone health were demonstrated in the vegetable mixture using highperformance liquid chromatography. RANKL/GAPDH mRNA transcription ratio showed marked an increase in OVXC versus the control NOVXC rats Conclusion:It may be concluded that the plant formula was effective to minimize health hazards in ovariectomized rats and maybe for postmenopause women. Perhaps longer time may be needed for more significant and clear effect.

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“…Dietary and serum, but not red cell, magnesium were generally lower among the elderly with osteoporosis 45,86,109 and among healthy older adults, magnesium intake was positively associated with BMD, BMC and bone mass 86,[110][111] , with an intake of >422.5mg/d vs <206.5 mg/d improving BMD 110 . A large multiethnic study found that this association may apply to older whites but not blacks 112 .…”

Section: Bonementioning

confidence: 98%

“…Although osteoporosis appears to have little association with serum calcium 45 , a review of observational studies found an association of low calcium intake and osteoporosis risk 40 , with an intake threshold of <400mg/d 46 . This may only be a shortterm association, possibly suggesting adaptation to a low calcium intake 47 .…”

Section: Bonementioning

confidence: 99%

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Cardiovascular Calcification and Bone: A Comparison of The Effects of Dietary and Serum Calcium, Phosphorous, Magnesium and Vitamin D

Nicoll¹

2015

ICFJ

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This comparison of the effects of calcium, phosphorus, magnesium and vitamin D on cardiovascular (CV) calcification and bone has shown that in general the micronutrients that promote bone health also protect the arteries. We have shown that adequate amounts of all three minerals should be ingested, paying particular attention to supplementing calcium to bind high phosphorus and to ensure the maximum benefit from supplementing vitamin D. It appears that the optimum intake for bone is >800 mg/d calcium, with postmenopausal women possibly requiring a total intake of >1100mg/d. Both CV and bone studies suggest achieving a serum 25(OH)D level of >75nmol/l. These relationships are valid for a Caucasian population, however, and may not hold in African Americans and Asians. The recent concerns that calcium supplementation may increase CV disease risk has largely proved groundless, with higher calcium intake improving dyslipidaemia, hypertension and mortality. With respect to higher serum phosphate, there is an association with CV calcification and CVD risk even within the normal range, suggesting that the reference ranges may need to be redefined for ‘at risk’ patients. CV calcification was reduced in CKD patients with magnesium intake in the range 384-669mg/d. When considering the complex interplay of the action of the minerals together with their regulators vitamin D, PTH and FGF23, it is clear that this is a very sophisticated system which attempts to maintain calcium homeostasis to the possible detriment of bone and arteries. This reinforces the need to ensure adequate calcium intake before supplementing vitamin D.

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Comparative evaluation of serum levels of main minerals and postmenopausal osteoporosis

Cited by 51 publications

References 20 publications

Interpregnancy interval as a risk factor for postmenopausal osteoporosis

Interpregnancy interval as a risk factor for postmenopausal osteoporosis

Rankl Expression and Metabolic Changes in Ovariectomized Rats and the Possible Protection by Vegetable Formula.

Cardiovascular Calcification and Bone: A Comparison of The Effects of Dietary and Serum Calcium, Phosphorous, Magnesium and Vitamin D

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