Comparative Evaluation of Selected Polymers and Plasticizer on Transdermal Drug Delivery System

Sethi, Bhawana; Mazumder, Rupa

doi:10.22159/ijap.2018v10i1.21960

Cited by 7 publications

(11 citation statements)

References 15 publications

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“…Hydrophilic polymers absorb moisture faster and to a greater extent than the hydrophobic polymers thus formulation batches F1 to F3 gave high moisture uptake value. Sethi et al [17] in their research also got similar results with a hydrophilic polymer. Percentage moisture uptake value of all formulation batches have given in table 5.…”

Section: Percentage Moisture Uptakementioning

confidence: 52%

Effect of Polymers on the Physicochemical and Drug Release Properties of Transdermal Patches of Atenolol

Kumar

Trivedi²,

Shukla³

et al. 2018

Int J App Pharm

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Objective: The objective of this research work was to develop a transdermal drug delivery system containing atenolol with different ratios of hydrophilic and hydrophobic polymeric combinations, using solvent evaporation technique and to examine the effect of hydrophilicity and hydrophobicity of polymers on the physicochemical and drug release properties of transdermal patches.Methods: Solvent casting method has been used to formulate transdermal patches. Hydroxypropyl methylcellulose (HPMC), Polyvinylpyrrolidone (PVP), Ethylcellulose (EC) in different combination ratios were used as the polymer. Propylene glycol was used as a plasticizer. Permeation enhancers such as span 80 were used to enhance permeation through the skin. In vitro diffusion study was carried out by franz diffusion cell using egg membrane as a semi-permeable membrane for diffusion.Results: Result showed that the thickness of the all batch of patches varied from 0.32 to 0.39 mm with uniformity of thickness in each formulation. Formulations F1 to F3 had high moisture content varied from 2.07±0.09 to 2.56±0.15 and high moisture uptake value varied from 3.21±0.35 to 4.09±0.38, due to a higher concentration of hydrophilic polymers. Drug content of all batches was ranged between 85.92±1.32 to 95.71±1.42. Folding endurance values off all batches were more than 75. Formulation batches F1 to F3 showed higher cumulative drug release varied from 61.34% to 68.11% as compared to formulation batches F4 to F6.Conclusion: Higher proportion of hydrophilic polymer in the formulation of transdermal patches, gives higher percentage drug release from prepared patches. The finding of the study indicates that hydrophilicity and hydrophobicity of polymer effects the physicochemical and drug release properties of transdermal patches and an optimum proportion of hydrophilic and hydrophobic polymer is required for the preparation of effective transdermal patches.

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Section: Percentage Moisture Uptakementioning

confidence: 52%

Effect of Polymers on the Physicochemical and Drug Release Properties of Transdermal Patches of Atenolol

Kumar

Trivedi²,

Shukla³

et al. 2018

Int J App Pharm

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“…Thus, the technique for the controlled release of drugs through TDDS is more efficient, appealing, and successful [16]. The transdermal patch shows to be beneficial compared to other drug delivery system, due to the following reasons [16][17][18][19][20][21][22][23][24][25][26]:…”

Section: Description About Tddsmentioning

confidence: 99%

“…first-pass metabolism, toxic metabolite formation, poor absorption, gastrointestinal irritation, etc. • TDDS is useful for medications that have a short half-life to prevent repeated dosing • Simplified medicines reduce inter and intra-patient variability • For unconscious patients with dysphagia or constipation, TDDS has a more significant advantage • Avoiding of pre-systemic metabolism leads to a reduction in the amount and, thus, a reduction in adverse effects in acute liver toxicity • The absorption of the drug can be terminated by withdrawing transdermal devices at any point in time • TDDS is usually cost-effective as patches, designed to deliver 1-7-day medications as compared with other treatments • In comparison with the nasal cavity, it provides a relatively wide range of applications [16][17][18][19][20][21][22][23][24][25][26].…”

Section: Description About Tddsmentioning

confidence: 99%

“…• The medication must have specific physicochemical properties for skin penetration, and if the dosage of a drug is high, i.e., it is challenging to deliver more than 10-25 mg/day by transdermal. The preferred average drug dosage is below 5 mg/days • The drug or the excipients used in the formulations may result in local irritation at the site of administration such as itching, erythema, and local edema • Clinical trial is required before applying the transdermal patches to the skin surface • At the site of operation, most patients experience dermatitis due to system components • The barrier function of the skin changes from one person to another person depending upon the age and the location from where they belong • Low skin permeability limits the number of medicines available in this way • TDDS is not an appropriate system to deliver the ionic drug molecules • Hormones are not the suitable candidates to deliver through the transdermal route [16][17][18][19][20][21][22][23][24][25][26].…”

Section: Limitations Of Tddsmentioning

confidence: 99%

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Extraction, Modification, and Characterization of Natural Polymers Used in Transdermal Drug Delivery System: An Updated Review

Biswas¹,

Das²,

Mohanto³

et al. 2020

Asian J Pharm Clin Res

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The modified/regulated drug delivery system helps to sustain the delivery of the drug for a prolonged period. The modified drug delivery system is primarily aimed at ensuring protection, the effectiveness of the drug, and patient compliance. The transdermal drug delivery system (TDDS) falls within the modified drug delivery system, in which the goal is to deliver the drug at a fixed dose and regulated rate through the skin. Polymers are the backbone of the framework for providing transdermal systems. The polymer should be stable, non-toxic, economical, and provide a sustainable release of the drug. In general, natural polymers used in the TDDS as rate-controlling agents, protective, and stabilizing agents and also used to minimize the frequency of dosing and improve the drug’s effectiveness by localizing at the site of action. Nowadays, manufacturers are likely to use natural polymers due to many issues associated with drug release and side effects with synthetic polymers. Drug release processes from natural polymers include oxidation, diffusion, and swelling. Natural polymers may be used as the basis to achieve predetermined drug distribution throughout the body. The use of natural materials for traditional and modern types of dosage forms are gums, mucilages, resins, and plant waste etc. Thus, the main objective of this review article is to give a brief knowledge about the extraction, modification, characterization, and biomedical application of conventional natural polymers used in the transdermal drug delivery system and their future prospective.

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“…The best formulation was selected by physicochemical properties and was subjected to further studies 13 .…”

Section: Evaluation Of Transdermal Patchmentioning

confidence: 99%

Untitled

2019

IJPSR

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The low bioavailability of drugs in the oral drug delivery system is the main concern and the development of a delivery system with a controlled release profile. This research aims in the dose reduction of aliskiren hemifumarate, evaluate the release efficacy of the drug from the patches by using various permeation enhancers. FTIR studies established the drug and polymer compatibility. The transdermal patches were prepared by using a solvent casting method using different polymers and permeation enhancers. The keshary chein diffusion cell was used for performing in-vitro permeation studies. By physicochemical parameters and in-vitro release pattern, the formulation made from MethocelK 15M (1:1.5) was selected for in-vivo studies. The steady plasma concentration was observed on application of developed transdermal patches, as confirmed by bioavailability studies in rats. The bioavailability was also improved as compared to oral administration. The SEM studies of transdermal patches show that the patches prepared with MethocelK 15M with cineol as penetration enhancer exhibited the uniform distribution of the drug. The hypertension was induced in rats using dexamethasone and treated with oral administration & application of the transdermal patch. The patches significantly controlled hypertension from the first hour. The stability studies indicated satisfactory performance as evaluated for assay & description on storage for six months. Conclusion: The developed transdermal patch exhibited therapeutic superiority over oral drug delivery.

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Comparative Evaluation of Selected Polymers and Plasticizer on Transdermal Drug Delivery System

Cited by 7 publications

References 15 publications

Effect of Polymers on the Physicochemical and Drug Release Properties of Transdermal Patches of Atenolol

Effect of Polymers on the Physicochemical and Drug Release Properties of Transdermal Patches of Atenolol

Extraction, Modification, and Characterization of Natural Polymers Used in Transdermal Drug Delivery System: An Updated Review

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