Comparative Evaluation of Rotahaler With Accuhaler Used for Delivery of Combination Drugs (Fluticasone and Salmeterol ) in Childhood Bronchial Asthma

Abstract

AIMTo compare efficacy of Rotahaler and Accuhaler using combination drugs of fluticasone and salmeterol in childhood bronchial asthma. MATERIALS AND METHODSA prospective study was planned with 60 patients of both sexes in the age group of 5-12 years, who reported to Asthma Clinic and fulfilled inclusion and exclusion criteria after parental consent. All patients included in the trial were initially entered into runin period of 2 weeks, during which a record was maintained of their clinical parameters and allowed to take their prescribed medication. At the end of run-in period the baseline symptoms and signs of asthma, PFT, amount of rescue medication and nocturnal awakening due to asthma symptoms were recorded. After run-in period, based on computer generated random numbered tables patients were randomized to receive either Rotahaler or Accuhaler with same combination medication. Statistical analysis was performed to compare both groups. CONCLUSIONThe present study demonstrated that there is no significant difference between Rotahaler and Accuhaler in clinical and PFT improvements in childhood bronchial asthma.