Comparative Evaluation of Photodynamic Therapeutic Probes for Peripheral Lung Cancer Based on Light Propagation Simulation

Abstract

This study evaluates photodynamic therapeutic probes for peripheral lung cancer by a preclinical trial based on computational simulation. By light propagation simulation based on a Monte Carlo method, light distributions in tissues by a direct transmission light irradiation probe and a diffused light irradiation probe were calculated to compare each irradiated volume. The simulated results demonstrated quantitatively that the diffused light irradiation probe can irradiate the tumor tissue more efficiently than the direct transmission light irradiation probe for peripheral lung cancer.