Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis

Patil, Santosh; Zarea, Kourosh; Maheshwari, Sneha; Sahu, Rajesh Kumar

doi:10.1016/j.jobcr.2014.12.005

Cited by 46 publications

(85 citation statements)

References 22 publications

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“…36,38,39 The OSMF is a well-known condition documented as being similar to the condition mentioned in ancient medicine by Susrutha called as "Vidari." 40 It was 1952 when the first description of OSMF was given by Schwartz under the title of "atrophica idiopathica mucosae oris."…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

“…A wide range of treatment modalities have been used, however, none have evolved as a promising treatment option. 36 Mainline of treatment used are quitting of betel nut and/ or tobacco chewing habit, counseling for diet, especially regarding spicy foods and chillies, and medicinal therapy. Commonly employed treatment includes medical therapy by use of corticosteroids, placental extracts, hyaluronidase, interferon gamma, and physiotherapy.…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

“…42,46,47 The role of minerals and micronutrients in treatment of OSMF has received impetus as they have been observed to bring about significant improvement in mouth opening (41%). 36 Similarly, vitamin A and oxitard capsules are also used for the treatment of OSMF. 36,47 Recently, Shetty et al 38 have delineated the role of Spirulina as an adjuvant therapy in the management of OSMF.…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

“…36 Similarly, vitamin A and oxitard capsules are also used for the treatment of OSMF. 36,47 Recently, Shetty et al 38 have delineated the role of Spirulina as an adjuvant therapy in the management of OSMF. They conducted an interventional study on 40 cases of OSMF.…”

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

See 3 more Smart Citations

Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis

Desai¹,

Hallikerimath²,

Kale³

2017

IJOCRWEB

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Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

Section: Role In Oral Submucous Fibrosismentioning

confidence: 99%

See 2 more Smart Citations

Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis

Desai¹,

Hallikerimath²,

Kale³

2017

IJOCRWEB

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“…The data of the 9 full -text articles were assessed for eligibility according to PICO guidelines. However, only 6 studies could be included in the systematic review after assessment of eligibility ( [17]. The extracted data resulted in 207 subjects using systemic antioxidants these subjects were considered to be in interventional group in the systematic review and meta -analysis.…”

Section: Data Extraction and Synthesis-mentioning

confidence: 99%

Systemic Antioxidants in Management of Oral Submucous Fibrosis: A Systematic Review of Randomised Control Trials and Meta–analysis.

Vijayalakshmi.¹,

Srivastava.²,

Khan.³

2017

IJAR

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Introduction: Antioxidants relieve the signs and symptoms of oral submucous fibrosis by decreasing the load of free radicals. Aim: The aim of this systematic review was to retrieve and analyse clinical studies investigating systemic antioxidants in the management of OSMF. Material and method: Literature was searched in electronic search engines from 1995 to 2015. The identified titles / abstracts were independently screened according to set criteria for selection of abstracts. The full -text articles retrieved were assessed for eligibility and the eligible studies were assessed for qualitative and quantitative evidence. 9 full text articles were selected and assessed for eligibility. 6 full text articles were eligible for qualitative and quantitative analysis. Meta -analysis was done for mouth opening. Results: The extracted data resulted in 207 subjects using systemic antioxidants. Meta -analysis of the combined data of the studies administering systemic antioxidants as a single entity or in combination with intralesional corticosteroids (n=121) as compared to other interventions (n=121) did not depict significant improvement in mouth opening (SMD = -1.446; 95% CI = -3.332 to -0.439) with significant test of heterogeneity (p = 0.0001 < 0.05). Meta -analysis of the combined data of all the interventional groups (n=207) and control groups (n=203) which depicted that systemic antioxidants as a single entity or in combination with intralesional steroids significantly improve mouth opening v/s controls (SMD = -1.235; 95% CI = -2.263to -0.206) with a significant test of heterogeneity (and p = 0.0001 < 0.05). Conclusion: Although the meta -analysis indicates that antioxidants appear to be effective in management of OSMF, the high degree of heterogeneity and limited amount of data in this systematic review and meta -analysis does not provide a credible evidence to support these observations.

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Interventions for managing oral submucous fibrosis

Jones,

Veale,

et al. 2024

Cochrane Database of Systematic Reviews

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Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis

Cited by 46 publications

References 22 publications

Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis

Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis

Systemic Antioxidants in Management of Oral Submucous Fibrosis: A Systematic Review of Randomised Control Trials and Meta–analysis.

Interventions for managing oral submucous fibrosis

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