Comparative evaluation of micronutrient status in the serum of diabetes mellitus patients and healthy individuals with periodontitis

Thomas, Biju; Kumari, Suchetha; Ramitha, K.; Kumari, Monika

doi:10.4103/0972-124x.65439

Cited by 34 publications

(39 citation statements)

References 6 publications

(5 reference statements)

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“…It is therefore quite possible that periodontitis causes lower plasma vitamin C through this mechanism [39]. In this study serum vitamin C level was lower in chronic periodontitis as compared to healthy controls, which was also documented by [40,41].Smokers are constantly over exposed to free radicals through inhalation of long lived carbon and oxygen centered radicals that subsequently deplete the plasma antioxidant vitamin C. Similar to our study, studies [42,43] have reported lower vitamin C levels in smokers than in non-smokers.…”

Section: Discussionsupporting

confidence: 73%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein.The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers.

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Section: Discussionsupporting

confidence: 73%

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

et al. 2013

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“…The results of the levels of glutathione and catalase were found to be significant, which are consistent with the outcomes of other studies. [12347]…”

Section: Discussionmentioning

confidence: 99%

“…[2] There is also a clearly defined and substantial role for ROS in periodontitis. [4] Antioxidants are substances that delay or prevent the oxidation of cellular oxidizable substrates.…”

Section: Introductionmentioning

confidence: 99%

A comparative evaluation of antioxidant enzymes and selenium in the serum of periodontitis patients with diabetes mellitus type 2

Thomas¹,

Ramesh²,

Suresh³

et al. 2013

Contemp Clin Dent

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Context:Chronic periodontitis is an inflammatory disease with an aberrant response characterized by exaggerated inflammation, involving the release of excess proteolytic enzymes and reactive oxygen species (ROS). Diabetes mellitus is a group of complex multisystem metabolic disorders characterized by a relative or absolute insufficiency of insulin secretion and or concomitant resistance to the metabolic action of insulin on target tissues. Increased production of ROS necessitates elevated requirements for the nutrients involved in antioxidant defenses: Selenium, zinc, and copper. Inflammatory states promote a decrease in the amount of systemic glutathione levels. Catalase is a central antioxidant enzyme constituting the primary defense against oxidative stress.Aims:This study has been designed to evaluate the comparison of glutathione, catalase, and selenium levels in the serum of diabetes mellitus type 2 patients and healthy individuals with and without periodontal disease.Settings and Design:This study is a case control study.Materials and Methods:The study was designed as a case - control study comprising of 150 subjects, inclusive of both sexes and were divided into three groups of 50 patients each. Group I: 50 subjects with type 2 diabetes mellitus and chronic periodontitis. Group II: 50 subjects who are systemically healthy with the chronic periodontitis. Group III: 50 subjects who are systemically healthy and not suffering fromPeriodontitis:Serum samples were taken for estimation of glutathione, catalase, and selenium from all groups, and Subjected to biochemical analysis after which atomic absorption spectrophotometry method was used to obtain their levels in serum.Statistical Analysis Used:ANOVA and Tukey HSD.Results:The serum levels of glutathione in diabetic patients with periodontitis were significantly lower with a mean of 61.36 + 8.054 when compared to healthy individuals with and without periodontitis with a mean of 56.93 + 6.874 and 90.36 + 6.564 respectively (P ≤ 0.005). The serum levels of catalase were significantly lower in diabetic patients with periodontitis with a mean of 19.30 + 7.355 when compared to healthy individuals with and without periodontitis with a mean of 20.71 + 6.472 and 36.09 + 5.108 respectively (P ≤ 0.005). The serum levels of selenium were significantly lower in diabetic patients with periodontitis with a mean of 81.41 + 55.419 when compared to healthy individuals with and without periodontitis with a mean of 161.44 + 84.787 and 193.84 + 66.713 respectively (P ≤ 0.005).Conclusions:The findings from the study suggest that the levels of glutathione, catalase, and selenium are significantly lower in diabetic patients with periodontitis and also in healthy individuals with periodontitis, but are highest in healthy controls, showing that the serum levels are inversely proportional to inflammation and tissue destruction.

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“…[456] Sprren Kiilerich et al . [7] observed that Zn absorption decreases in diabetes, thereby leading to its intracellular depletion.…”

Section: Introductionmentioning

confidence: 99%

Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis

Pushparani¹,

Anandan²,

Theagarayan³

2014

J Indian Soc Periodontol

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Aim:The purpose of the study was to evaluate the serum levels of zinc (Zn) and magnesium (Mg) in type 2 diabetes mellitus (DM) with periodontitis patients and to correlate them with the levels of serum cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), and triglycerides among the study subjects.Materials and Methods:A total of 600 subjects participated in the study, who were divided into four groups as control healthy individuals (group I), type 2 DM without periodontitis (group II), type 2 DM with periodontitis (group III), and periodontitis subjects without DM (group IV), matched for age, sex, and duration of diabetes. Serum concentrations of glucose, total cholesterol, triglycerides, HDL-c, Zn, and Mg were measured using enzymatic methods in an UV absorption spectrophotometer, and LDL-c was calculated using Friedwald's formula. Student's t-test, Pearson correlations, and analysis of variance (ANOVA) tests were used for statistical analysis.Results:The serum zinc level was found to be significantly increased in type 2 DM without periodontitis (group II) and periodontitis subjects without type 2 DM (group IV) (P < 0.0001), and the level was lowered in type 2 DM with periodontitis (group III) when compared to control. The serum Mg level was found to be significantly decreased (P < 0.0001) in group II, group III, and in group IV, when compared to control. We found a significant increased level of serum total cholesterol and LDL-c and decreased triglycerides and HDL-c in type 2 DM subjects with periodontitis (group III, P < 0.0001).Conclusion:Patients with DM and periodontitis had altered metabolism of Zn and Mg which were linked to increased values of serum cholesterol and LDL-c and decreased HDL-c, contributing to the progression and complications of type 2 DM with periodontitis.

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Comparative evaluation of micronutrient status in the serum of diabetes mellitus patients and healthy individuals with periodontitis

Cited by 34 publications

References 6 publications

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

Assessment of Some Biochemical Oxidative Stress Markers in Male Smokers with Chronic Periodontitis

A comparative evaluation of antioxidant enzymes and selenium in the serum of periodontitis patients with diabetes mellitus type 2

Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis

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