“…In the asymptomatic stage, which has an average duration of 8-10 years, early changes can already be identified at MRCP (irregularities, parietal impressions, stenosis) with or without altered biochemical tests (minor increase in alkaline phosphatase and bilirubin levels) [14]. Biliary colic, jaundice, cholestasis and cholangitis appear late in the evolution of the disease and only in patients with advanced changes at MRCP [8]. Risk factors for the occurrence of symptomatic PCC are: prolonged duration of the disease, history of variceal hemorrhage, cholestasis, bile duct stones and advanced (grade III) cholangiographic findings (biliary strictures, dilatations) [15].…”