Comparative Evaluation of Healing Pattern After Surgical Excision of Oral Mucosal Lesions by Using Platelet-Rich Fibrin (PRF) Membrane and Collagen Membrane as Grafting Materials—A Randomized Clinical Trial

Mahajan, Monica; Gupta, Mithilesh Kumar; Bande, Chandrashekhar; Meshram, Vikas

doi:10.1016/j.joms.2018.02.031

Cited by 13 publications

(8 citation statements)

References 9 publications

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“…Based on these considerations, interest in the use of platelet concentrates (PCs) for the treatment of many intraoral clinical conditions, including periodontal and furcation defects, is rising [ 15 ]. The rationale behind the preparation of platelet concentrates is that concentrated platelets and autologous growth factors could be collected from a whole blood sample through centrifugation and used in a surgical site to promote local healing [ 16 , 17 , 18 ]. In particular, natural fibrin is a biological three-dimensional matrix, enmeshed with platelets, cytokines, glycanic chains, and structural glycoproteins, which acts as a suitable network for breeding human periosteal cells, fibroblasts, and endothelial cell in tissue engineering [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

Tarallo

Mancini

Pitzurra

et al. 2020

JCM

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In periodontitis patients, furcation defects are crucial sites to regenerate due to their complex anatomy. Various modern surgical techniques and use of biomaterials have been suggested in the literature. Among all, platelet-rich fibrin (PRF) has potential in tissue regeneration thanks to its role in the release of growth factors. Therefore, the purpose of this study was to evaluate the beneficial effect of the addition of PRF to open flap debridement (OFD) or as an adjuvant to other biomaterials such as bone grafts in the treatment of grade 2 mandibular furcation defects. Systematic research was carried out on the databases Medline, Scopus, Embase, and Cochrane Library and registered on PROSPERO (CRD42020167662). According to the PICO guidelines by Cochrane, randomized trials and prospective non-randomized trials were evaluated, with a minimum follow-up period of 6 months. The inclusion criteria were the absence of systemic diseases, non-smoking patients, and a population aged from 18 to 65 years. Vertical pocket probing depth (PPD), vertical clinical attachment level (VCAL), and gingival recession (REC) were the primary outcomes. Vertical furcation depth (VFD), and the percentage of bone defect fill (%v-BDF) were considered as secondary outcomes. A meta-analysis of the primary and secondary outcomes was performed. Publication bias was assessed through a funnel plot. Eighty-four articles were initially extracted. Eight randomized clinical trials were analyzed according to the exclusion and inclusion criteria. The Quality assessment instrument (QAI) revealed four articles at low risk of bias, one at moderate, and three at high risk of bias. The metanalysis showed significant data regarding PPD, VCAL, VFD and %v-BDF in the comparison between PRF + OFD vs. OFD alone. The adjunct of PRF to a bone graft showed a significant difference for VCAL and a not statistically significant result for the other involved parameters. In conclusion, the adjunctive use of PRF to OFD seems to enhance the periodontal regeneration in the treatment of grade 2 furcation defects. The combination of PRF and bone graft did not show better clinical results, except for VCAL, although the amount of literature with low risk of bias is scarce. Further well-designed studies to evaluate the combination of these two materials are therefore needed.

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Section: Introductionmentioning

confidence: 99%

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

Tarallo

Mancini

Pitzurra

et al. 2020

JCM

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“…Only studies that were published within 3 years of the search date were included ( n = 60). After duplicate removal and screening, 50 articles were included in the analysis 35‐84 (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…Dayashankara Rao et al reported that the application of i‐PRF and A‐PRF in addition to bone graft alone (control) during cleft palate repair produced favourable outcomes, although there was no statistical analysis and the risk of bias was judged to be high 42 . Similarly, an unblinded study favoured L‐PRF membranes over collagen membranes as a dressing for excision wound sites but was also judged to be at high risk of bias 65 . Tabrizi et al conducted two similar studies, 45,53 focussing on Le Fort I osteotomy and bilateral sagittal‐split osteotomy, respectively.…”

Section: Discussionmentioning

confidence: 99%

What recent evidence exists to support the use of platelet‐rich fibrin in clinical dentistry? A systematic literature review

Savva

2022

Oral Surgery

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Background Platelet‐rich fibrin (PRF) is a second‐generation platelet concentrate and biomaterial with multiple applications in clinical dentistry. Recent developments in the production of PRF have resulted in several divergent protocols that could be seen to affect the reproducibility and generalisability of the available literature. Additionally, imprecise reporting on PRF production is a further confounding factor with respect to previous trial data. Aims The primary aim of this review was to assess the recent clinical trial data relating to the use of PRF, irrespective of centrifugal protocol, in clinical dentistry. Methods A systematic literature review was carried out in PubMed and the Cochrane Library databases to select English language, human clinical trials involving the use of PRF published between July 2018 and July 2021. Results The 50 included studies demonstrated an overall clinical benefit for the use of PRF in the fields of oral medicine, oral surgery and periodontology, with unclear benefits in the field of endodontology, and no clear benefit in the field of orthodontics. Only 16% of the included studies met published standards for reporting PRF production protocols, and meeting such standards should be an essential requirement for future publications. Conclusions There was little direct evidence to support one particular PRF protocol over another and this remains an area of controversy. Future research should focus on precise reporting of PRF protocols, and in areas where PRF is of known benefit, the use of different production methods should be compared to assess what, if any, clinical significance is attached to particular centrifugation protocols and tubes.

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“…In addition, the combination of PRF and bone substitutes used in immediate implantation presents an excellent promotion of osteogenesis and remarkable acceleration of bone healing under inflammatory conditions[ 34 ]. Compared with the collagen membrane, PRF has better and faster healing with fewer postoperative complications for grafting of oral soft tissue defects[ 35 , 36 ]. Therefore, in this case, PRF was mixed with the bone substitute to reduce the inflammatory response in extraction socket, preventing the interference with bone regeneration and accelerating the early bone healing.…”

Section: Discussionmentioning

confidence: 99%

“…The PRF on the surface of Bio-Oss was designated to facilitate the osseointegration and provide the profitable space for cell proliferation and migration[ 37 , 38 ]. The PRF placed over the collagen membrane served as a protective barrier to promote the remodeling of soft tissue, while minimizing the risk exposure of internal membrane and lessening the scar formation of soft tissues[ 35 ]. As shown in this case, CBCT and clinical assessment have both represented the great osseointegration and satisfactory contour of gingival in the aesthetic area.…”

Section: Discussionmentioning

confidence: 99%

Immediate implant placement in combination with platelet rich-fibrin into extraction sites with periapical infection in the esthetic zone: A case report and review of literature

Fang

Xin

et al. 2021

WJCC

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BACKGROUND In this case, platelet-rich fibrin (PRF) was added to guided tissue regeneration as a biomaterial in proper order for immediate planting in aesthetic area with periapical infection. CASE SUMMARY With the history of endodontic failure in maxillary central incisor, a 34-year-old female patient required the extraction of maxillary anterior residual root and immediate implantation. Cone beam computed tomography and clinical observation were used to assess the regeneration of soft and bone tissue. Before operation, cone beam computed tomography showed the anterior residual root had serious periapical periodontitis with insufficient labial bone in the aesthetic zone. The patient underwent immediate implant placement and reconstruction of the bone substitution by modified guided bone regeneration. The barrier was a three-layer structure of PRF-collagen membrane-PRF that covered the mixture of PRF and Bio-Oss to promote both osteogenesis and soft tissue healing. At 6 mo postoperatively, the definitive crown was placed after accomplished finial impression. One-year follow-up showed a satisfactory aesthetic effect with no obvious absorption of the labial bone and soft tissue. CONCLUSION The use of PRF in combination with guided bone regeneration can serve as a reliable and simple adjuvant for immediate implanting in infected socket and result in a stable osteogenic effect with good aesthetic outcome.

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Comparative Evaluation of Healing Pattern After Surgical Excision of Oral Mucosal Lesions by Using Platelet-Rich Fibrin (PRF) Membrane and Collagen Membrane as Grafting Materials—A Randomized Clinical Trial

Cited by 13 publications

References 9 publications

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis

What recent evidence exists to support the use of platelet‐rich fibrin in clinical dentistry? A systematic literature review

Immediate implant placement in combination with platelet rich-fibrin into extraction sites with periapical infection in the esthetic zone: A case report and review of literature

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