Comparative evaluation of four therapeutic regimes in chikungunya arthritis: a prospective randomized parallel-group study

Padmakumar, B; Jayan, Jacob B; Menon, Rejeesh; Krishnankutty, Binny; Payippallil, Rajan; Nisha, R.S.

doi:10.1016/s0973-3698(10)60189-6

Cited by 42 publications

(35 citation statements)

References 12 publications

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“…aspirin) should be avoided (Goupil and Mores, 2016). The co-administration of NSAIDs with low-dose systemic corticosteroids has been recommended to reduce pain and improve quality of life in treating acute chikungunya cases with arthralgia (Padmakumar et al, 2009). Past concerns that corticosteroid treatment may exacerbate alphaviral arthritides appear unjustified, since serodiagnosis has demonstrated antiviral immunity (Mylonas et al, 2004).…”

Section: Treatmentmentioning

confidence: 99%

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

et al. 2018

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Chikungunya fever is a mosquito-borne viral illness characterized by a sudden onset of fever associated with joint pains. It was first described in the 1950s during a Chikungunya virus (CHIKV) outbreak in southern Tanzania and has since (re-) emerged and spread to several other geographical areas, reaching large populations and causing massive epidemics. In recent years, CHIKV has gained considerable attention due to its quick spread to the Caribbean and then in the Americas, with many cases reported between 2014 and 2017. CHIKV has further garnered attention due to the clinical diagnostic difficulties when Zika (ZIKV) and dengue (DENV) viruses are simultaneously present. In this review, topical CHIKV-related issues, such as epidemiology and transmission, are examined. The different manifestations of infection (acute, chronic and atypical) are described and a particular focus is placed upon the diagnostic handling in the case of ZIKV and DENV co-circulating. Natural and synthetic compounds under evaluation for treatment of chikungunya disease, including drugs already licensed for other purposes, are also discussed. Finally, previous and current vaccine strategies, as well as the control of the CHIKV transmission through an integrated vector management, are reviewed in some detail.

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Section: Treatmentmentioning

confidence: 99%

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

et al. 2018

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“…To relieve pain, acetaminophen (500-750 mg every 6 h, not exceeding 4 g/day), tramadol (50-100 mg every 6 h) and codeine (30 mg each 6 h), or oxycodone (10-20 mg every 12 h), are recommended. 11,[41][42][43][44] As mentioned earlier, owing to the risk of co-infection because of co-circulating viruses that share vectors, such as DENV and Zika, along with other arboviruses sharing mosquito vectors, unless and until Dengue is ruled out, use of aspirin and NSAIDs is not recommended, in order to reduce bleeding risk.…”

Section: Treatment-chikungunya Arthritis/painmentioning

confidence: 99%

“…11 Cold compresses may reduce joint pain. 11,43,45 Maintaining mobility and preventing functional impairment are important. 11,41 Patients with neuropathic pain may benefit from amitriptyline or gabapentin.…”

Section: Treatment-chikungunya Arthritis/painmentioning

confidence: 99%

Selected mosquito-borne illnesses—Chikungunya

McFee

2018

Disease-a-Month

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“…Currently, there is no vaccine for the prevention of CHIKV infection, or a specific treatment for CHIKV infection and its potential sequelae. Non‐steroidal anti‐inflammatory drugs, steroids, and opioids are used to control some of the symptoms of chronic inflammatory arthritis …”

Section: Introductionmentioning

confidence: 99%

Chikungunya in solid organ transplant recipients, a case series and literature review

Rosso

Rodríguez

Cedano

et al. 2018

Transplant Infectious Dis

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Chikungunya virus is a recent emerging arbovirus in Latin America, and the clinical manifestations can vary from fever and rash to severe chronic inflammatory arthritis. Few reports have been published regarding this infection in immunocompromised patients, including solid organ transplant recipients. We report a case series of solid organ transplant recipients with confirmed Chikungunya infection by positive reverse transcription polymerase chain reaction (RT-PCR), identified between January 2014 and December 2016. In addition, we conducted a literature review searching PubMed, EMBASE, and LILACS databases on Chikungunya infection in solid organ transplant recipients. Ten solid organ transplant recipients were included, consisting of 5 kidney, 4 liver, and 1 liver/kidney transplant recipient. Mean age of the transplant recipients was 47 years, and the most frequent symptoms of Chikungunya infection were arthralgia and fever. None of the patients required treatment in the intensive care unit, no deaths or graft rejection occurred. None of our patients had recurrent arthritis during 3-month follow-up period after the infection. Twenty-one cases of Chikungunya virus were identified in the literature review. Most cases had a benign clinical course with no severe complications, death, or chronic inflammatory arthritis. In conclusion, Chikungunya infection in solid organ transplant recipients has a benign course and has no chronic recurrent arthritis. It is possible that the immunosuppression regimen could decrease the risk of severe or chronic inflammatory manifestations in solid organ transplant recipients infected with Chikungunya.

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Comparative evaluation of four therapeutic regimes in chikungunya arthritis: a prospective randomized parallel-group study

Cited by 42 publications

References 12 publications

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

A scoping review of Chikungunya virus infection: epidemiology, clinical characteristics, viral co-circulation complications, and control

Selected mosquito-borne illnesses—Chikungunya

Chikungunya in solid organ transplant recipients, a case series and literature review

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