Comparative Evaluation of Flow for Pharmaceutical Powders and Granules

Shah, Rakhi B.; Tawakkul, Mobin A.; Khan, Mansoor A.

doi:10.1208/s12249-008-9046-8

Cited by 381 publications

(226 citation statements)

References 10 publications

Supporting

Mentioning

186

Contrasting

Unclassified

Order By: Relevance

“…Thus powder blends were evaluated for Hausner's ratio and Carr's index before tablet compression. Hausner's ratio and Carr's index of powder blends were less than 1.2 and 11 respectively, indicating a good flowability of powder blends (Shah, Tawakkul, Khan, 2008). MLX ODTs were prepared by the direct compression method because it is an easy and low-cost method (Medina, Kumar, 2006).…”

Section: Preparation and Characterization Of Odtsmentioning

confidence: 99%

Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion

Shoormeij

Taheri

Homayouni

2018

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and exhibits a slow onset of action. In this study, MLX solid dispersions (MLX SDs) were prepared to improve the water solubility of this poorly water-soluble drug. Then orally disintegrating tablets (ODT) of MLX were developed using MLX SD to decrease the onset of action of this drug. MLX, poloxamer 188, and crospovidone of different ratios were melted in molten poloxamer 188 as a hydrophilic carrier. The optimum SD with the highest saturation solubility in water (13.09±0.34 microgram/mL) consisting of MLX: poloxamer 188: crospovidone in the ratio of 1:2:0 was used for the preparation of MLX ODTs. MLX ODTs were prepared by the direct compression method and optimized by the 2 3 factorial design. The effect of the superdisintegrant concentration, the mannitol-avicel ratio, and the level of compression force on the disintegration time, hardness, and percent of dissolved MLX from MLX ODTs after 30 min was evaluated. DSC and XRD analysis approved an amorphous form of MLX in SDs. The optimized ODT formulation containing 10% of superdisintegrant, and mannitol and avicel in the ratio of 4:1 respectively was compressed using a high level of compression force. The optimized ODT showed hardness (34.37±2.1 N) and friability (1.26±0.04%). This formulation showed a rapid disintegration in 12.66±2.5 seconds, which 82.66±5.1% of the MLX released within 30 min. MLX ODTs, prepared from MLX SD, could be introduced as a suitable dosage form of MLX with improved solubility and the onset of action.

show abstract

Section: Preparation and Characterization Of Odtsmentioning

confidence: 99%

Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion

Shoormeij

Taheri

Homayouni

2018

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…Previously weighed magnesium stearate and Aerosil were added in the blend and again mixed for 2 min. The pre-compression studies were performed to assure free flowing nature of the powder mixture (11). The resulting powder mixture was directly compressed using a 9-mm concave punch on a rotary tablet press (General Machinery Company, Mumbai).…”

Section: Preparation Of Cpopmentioning

confidence: 99%

Development and Evaluation of a Once-Daily Controlled Porosity Osmotic Pump of Tapentadol Hydrochloride

2015

View full text Add to dashboard Cite

Abstract. The present study aimed to prepare, optimize, and evaluate Tapentadol hydrochloride controlled porosity osmotic pump (CPOP) and to achieve the drug release at nearly zero-order. The CPOP was prepared by the coating of polymers (Eudragit RSPO and RLPO) on a directly compressed core tablet. A Box-behnken experimental design was applied to optimize the parameters for CPOP. The optimized batch was characterized for in vitro drug release study, effect of pH, osmolarity and agitation intensity, and surface morphology and stability study. In vivo pharmacokinetic studies were performed on New Zealand white rabbits for CPOP and marketed tablet. All the batches showed a drug release ranging from 29.87 to 56.92% after 12 h; and from 59.64 to 99.96% after 24 h. There was no change in the drug release pattern at different pH and agitation intensities. The drug release was found to decrease with increasing osmolarity of dissolution media.An in vivo study showed a higher mean residence time, area under the curve, and biological half-life (T 1/2 ) than the marketed tablet with low rate of elimination (Ke) and a 2.35-fold increase in relative bioavailability. The result showed that the amounts of sodium chloride and PEG 400 were contributing positively while the number of coats was negatively affecting the drug release. The drug release was found to be independent of physiological conditions. The stability testing showed that the prepared CPOP was stable for 3 months at accelerated conditions. The prepared CPOP was found to deliver Tapentadol hydrochloride at zero-order for up to 24 h.

show abstract

“…The angle of repose is an old and simple technique that also gives a general idea of the cohesivity and flow properties of powder; however, it is heavily affected by the methodology of the test and may not be highly reproducible. 37) Nevertheless the angle of repose of the formulated powder was determined in the present case and the results showed 'excellent' values as per the USP guideline. Similarly the flow rate of the powder was found to be less than 1 s substantiating the good flow property of the powder.…”

Section: Resultsmentioning

confidence: 52%

Development and Characterization of Solid Self-emulsifying Drug Delivery System of Cilnidipine

Bakhle

Avari

2015

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

The present investigations highlight the development of solid self-emulsifying drug delivery system (solid-SEDDS) for improved oral delivery of the poorly water-soluble drug; cilnidipine. Liquid SEDDS of the drug were formulated using Capryol 90 as the oil phase, Tween 80 as the surfactant, and Transcutol HP as the co-surfactant after screening various vehicles. The prepared systems were characterized for selfemulsification time, robustness to dilution, % transmittance, globule size, drug release, and thermodynamic stability. Ternary phase diagrams were plotted to identify the area of microemulsification. The optimized liquid SEDDS was transformed into a free-flowing powder using Neusilin US2 as the adsorbent. Solid selfemulsifying powder retained the self-emulsifying property of the liquid SEDDS. Differential scanning calorimetric, X-ray powder diffraction studies revealed the possibility of transformation of the crystalline form of the drug to the amorphous form in the SEDDS prepared with the carrier. The morphology of solid-SEDDS from scanning electron microscopy studies demonstrated the presence of spherical, granular particles indicating good flowing ability. Dissolution studies revealed enhanced dissolution of the drug from the solid system compared with the pure drug and its marketed formulation. Similarly, the in vitro absorption profile of the drug from the formulated SEDDS was significantly higher compared with pure drug. Thus it can be concluded that solid-SEDDS, amenable for development of solid dosage form, can be successfully developed using Neusilin US2 with the potential of enhancing the solubility, dissolution rate, and bioavailability of the drug. Key words cilnidipine; solid self-emulsifying drug delivery system (SEDDS); adsorption; crystallinity; droplet size; drug release Poorly water-soluble drug candidates often emerge from contemporary drug discovery programs, and present formulators with considerable technical challenges. The absorption of such compounds when presented in the crystalline state to the gastrointestinal tract is typically dissolution rate-limited, and the drugs are typically Biopharmaceutical Classification System (BCS) class II or class IV compounds.1) The interests on lipid-based drug delivery systems (LBDDS) have increased over the past two decades as a function of identification of these pharmaceutically difficult candidates, and increased even further after successful launch of lipid-based oral pharmaceutical products, including in particular cyclosporine A, marketed as Sandimmune and Neoral . 2)Lipid based drug delivery system such as self-emulsifying drug delivery systems (SEDDS) are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastrointestinal tract. Hydrophobic drugs can often be dissolved in SEDDS allowing them to be encapsulated as unit dosage forms for peroral administration.3-5) When such a system is released in the lum...

show abstract

Comparative Evaluation of Flow for Pharmaceutical Powders and Granules

Cited by 381 publications

References 10 publications

Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion

Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion

Development and Evaluation of a Once-Daily Controlled Porosity Osmotic Pump of Tapentadol Hydrochloride

Development and Characterization of Solid Self-emulsifying Drug Delivery System of Cilnidipine

Contact Info

Product

Resources

About