Comparative Evaluation of Efficiency of Different Herbal Medicinal Products Containing Orthília Secúnda in Treatment of Chronic

Fadeeva, N. I.; Ремнева, О. В.; Yavorskaya, S.D.; Skoropatskaya, O.A.

doi:10.31684/2541-8475.2017.3(7).43-46

Cited by 3 publications

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“…For example, the study [3] proved high efficiency of the use of such phytobiotics as Orthilia secunda on the regenerative functions of protozoa. In general, Orthilia secunda is a very valuable phytobiotic [1,7] containing many beneficial substances and trace elements, and it has anti-inflammatory, diuretic, and tonic properties [10]. However, little is known about its properties in animal nutrition and gastrointestinal functioning.…”

Section: Conditions Materials and Methodsmentioning

confidence: 99%

Development of technologies for the production of innovative phytobiotic and adaptogenic additives for animal nutrition

Ermolaev

2023

E3S Web Conf.

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The positive effects of phytogens on the growth, health, immunity and productivity of animals have been proven and they are often used in the form of essential oils and herbal extracts. There is evidence supporting the ability of phytogenic compounds, including extracts from alfalfa seeds, herbs, and essential oils, to influence the digestive system. We propose to study the innovative phytobiotic (Orthília secúnda) and adaptogenic (Velvet antlers) additives for animal nutrition. In this article we use a completely new technology of vacuum drying, which will allow phyto-additives to preserve all beneficial biological properties and be included in the diet of animals immediately after drying. Our new technology of vacuum drying will increase the shelf life of the supplemental product and receive the additives with predictable chemical composition and properties.

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Section: Conditions Materials and Methodsmentioning

confidence: 99%

Development of technologies for the production of innovative phytobiotic and adaptogenic additives for animal nutrition

Ermolaev

2023

E3S Web Conf.

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“…Використання фітопрепаратів під час лікування хворих людей і тварин з запальними процесами в статевих органах описано в багатьох літературних джерелах (Fadeeva et al, 2017;Mandhwani et al, 2017;Khalipaev et al, 2021).…”

Section: рис 5 запліднюваність свиноматок після лікуванняunclassified

The Effectiveness of Intrauterine Injection of Fit-O-Methrin Drug for Endometritis in Sows

Kraevskiy

Шевченко²,

Baban

et al. 2021

SCIVP

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The article presents data on the establishment of the effectiveness of intrauterine administration of the experimental herbal preparation Fit-O-Metrin based on extracts of thyme, oregano and barberry in postpartum endometritis in sows. Inflammation of the mucous membrane of the uterus is a fairly common disease of the genitals in sows, especially after farrowing, which often occurs against the background of viral infection due to bacterial or parasitic contamination of the uterus, as well as due to violation of veterinary rules of pigs and feeding poor quality feed, fungus and their toxins. In most cases, endometritis in sows secretes bacterial microflora and is treated with drugs to which the microflora is not resistant or use new broad-spectrum antibiotics, but it is known that they act not only on its microflora but also saprophytes of the vagina and its dorsum, turn may be the etiological factor of settlement in these organs of antibiotic-resistant bacteria. Treatment of 20 sows of the control group was carried out according to the protocol adopted in the farm: Cobactan at a dose of 4 ml per 100 kg intramuscularly, once a day for 3 days, Dexafort at a dose of 1 ml per 50 kg, intramuscularly, once, Introvit in dose of 10.0 ml per animal, intramuscularly once, Catozal at a dose of 10.0 ml per animal, intramuscularly once, Galapan at a dose of 2.0 ml per animal intramuscularly, once. 10 animals of the experimental group to this protocol in the uterus was injected Fit-O-Metrin drug at a dose of 30.0 ml once. During the studies, the duration of exudate secretion after the end of treatment was taken into account and a sonographic examination of the uterus was performed, in addition, the nature of uterine secretions before insemination was taken into account. 30-35 days after insemination with the help of a sonographic device examined the condition of the uterus of sows to diagnose pregnancy or infertility. The prevalence of postpartum catarrhal-purulent and purulent endometritis among sows after farrowing was 25.0 %, purulent exudate was excreted in 30 % of sick animals, in the rest (70 %) purulent-catarrhal exudate flowed from the vagina. After using Fit-O-Metrin drug for postpartum endometritis in sows, the number of animals admitted to insemination increased by 55.0 % (p≤0.001), and their fertility by 34.4 % (p≤0.05).

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Identification and quantitative determination of arbutin in the herb of Orthilia secunda

Lezina

Тернинко

Krys'Ko

2021

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Orthilia secunda (L.) House is a perennial herb that grows in Europe, Siberia, Asia Minor and Central Asia. The herb of Orthilia secunda is actively used in folk medicine as a diuretic, wound-healing and anti-inflammatory agent. From literary sources it is known that this medicinal plant raw material (PRM) contains flavonoids, tannins, organic acids, vitamins, as well as simple phenols and their derivatives (arbutin and hydroquinone). The presence of arbutin is responsible for the plant's high antioxidant and anti-inflammatory properties. But the use of Orthilia secunda in official medicine is limited due to the lack of complete information on the chemical composition and criteria for standardization of this type of medicinal product.Aim. Identification and quantification of arbutin by chromatographic methods in Orthilia secunda (L.) House, harvested in various phytocenotic zones.Materials and methods. The investigated medicinal plant material – the herb of Orthilia secunda – was harvested in various phytocenotic zones: in July 2018, harvesting was carried out in the northern part of Kazakhstan (Kokshetau district), in July-August 2019 in the Perm Territory and in the Tyumen Region. Preliminary identification of arbutin and related phenols – gallic acid and hydroquinone – was carried out by high performance thin layer chromatography (HPTLC) on a CAMAG instrument with a UV cabinet (Merck HPTLC silica gel 60 F154 plates, 20 × 10), semi-automatic Linomat 5 applicator (sample application). Elution of the plates was performed in a CAMAG Automatic Developing Chamber (ADC2). Image fixation was performed on a CAMAG Scanner 3 spectrodensitometer. The quantitative determination of arbutin was carried out by the method of highperformance liquid chromatography, which was carried out on a Prominence LC-20 device (Shimadzu, Japan) according to the validated method described in the European Pharmacopoeia 10.0. Diode array detector SPD-M20A, column Intersil C18 column (250–4.6 mm, 5 μm) (Phenomenex, USA). The results were processed using the LabSolution software. The identification and quantification of arbutin was carried out in comparison with a standard solution containing a reference sample (RS) of arbutin (C = 0,025 mg/ml) and RS of hydroquinone (C = 0,0125 mg/ml).Results and discussion. HPTLC analysis made it possible to detect arbutin and gallic acid – the main product of hydrolytic degradation/ precursor of the biosynthesis of tannins of the hydrolysable group – in the herb of Orthilia secunda from different places of growth. HPLC analysis demonstrates a different chromatographic profile of Orthilia herb harvested in different phytocenotic zones. However, in all studied objects, the absence of hydroquinone and the presence of substances that can presumably be attributed to its derivatives were confirmed, which is confirmed by the visual similarity of the spectra of these compounds and the proximity of the extrema. It was found that arbutin does not belong to the marker (majority) compounds of Orthilia. Its content is low and reaches a maximum (about 0,021 %) in the herb of Orthilia secunda growing on the territory of Kazakhstan, while in the herb of Orthilia harvested in the Perm Territory arbutin was not identified. From the data obtained, it follows that the greatest accumulation of arbutin occurs in areas with a warmer and drier climate (northern part of Kazakhstan).Conclusion. HPTLC analysis of the herb Orthilia secunda allowed the identification of arbutin and gallic acid (the main precursor of tannins of the hydrolysable group). The results of HPLC analysis of Orthilia herb harvested in various phytocenotic zones suggest quantitative differences in the content of arbutin depending on the region of growth. From the experimental data, it follows that Orthilia growing in the northern part of Kazakhstan accumulates the maximum (0,021%) amount of arbutin, in comparison with the samples harvested in the Tyumen region and the Perm region. At the same time, Orthilia harvested in the Perm Territory does not accumulate arbutin. The presence of hydroquinone has not been confirmed (by HPTLC and HPLC methods); therefore, it is not justified to talk about the hydrolytic cleavage of arbutin in the process of biosynthesis or drying. However, in all studied objects there are peaks of substances with spectral characteristics like hydroquinone, which makes it possible to assume the presence of its derivatives. Therefore, it is not advisable to position arbutin as a marker compound of Orthilia secunda harvested on the territory of the Russian Federation, and to standardize raw materials for this compound.

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Comparative Evaluation of Efficiency of Different Herbal Medicinal Products Containing Orthília Secúnda in Treatment of Chronic

Cited by 3 publications

References 0 publications

Development of technologies for the production of innovative phytobiotic and adaptogenic additives for animal nutrition

Development of technologies for the production of innovative phytobiotic and adaptogenic additives for animal nutrition

The Effectiveness of Intrauterine Injection of Fit-O-Methrin Drug for Endometritis in Sows

Identification and quantitative determination of arbutin in the herb of Orthilia secunda

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