Comparative Evaluation of Efficacy of Midazolam in Different Doses as an Induction Agent

Abstract

BACKGROUNDInduction involves the transition from an awake conscious state with intact productive reflexes to an unconscious state. Induction is accomplished when there is no response to oral commands and loss of eyelash reflexes. The Induction of general anaesthesia is characterised by rapid loss of consciousness which is an indicator of light surgical plane of anaesthesia. Midazolam is a water soluble short-acting benzodiazepine. Midazolam possesses some of the properties of an ideal intravenous anaesthetic agent and hence has been evaluated as an induction agent for an ideal dosage.The aim of the study was to find out a minimum effective dose of midazolam by comparing 0.25 mg/kg and 0.30 mg/kg body weight as an induction agent in general anaesthesia and study about its responses namely smoothness of induction, haemodynamic changes and respiratory status during induction. MATERIALS AND METHODSIn this prospective randomised and double-blind study, sixty cases posted for abdominal surgeries were enrolled. Patients received the study drugs in a randomised manner. Group I patients received midazolam 0.25 mg/kg while group II patients received midazolam 0.3 mg/kg for induction of anaesthesia. The observations were analysed using student's test and Chi-square test to compare the data between groups. RESULTSMidazolam can be used as an induction agent in patients undergoing major surgical procedures without any systemic complications. CONCLUSIONThis study showed that Midazolam in a dose of 0.3 mg/kg was more ideal to induce clinically acceptable anaesthesia since induction and recovery were smooth and pleasant.