Comparative Evaluation of Calcium Phosphates, Hydroxyapatite and Bone using Raman Spectroscopy

Abstract

The purpose of this study was to evaluate synthetic calcium phosphates and animal bones using Raman spectroscopy, and explore the possibility of its application in characterizing newly formed bone around implants. Synthetic calcium phosphates (monobasic calcium phosphate, dibasic calcium phosphate and tribasic calcium phosphate), hydroxyapatite and rabbit bones with and without implants were analyzed in this study. Slight differences in the Raman bands among the 3 types of synthetic calcium phosphate and hydroxyapatite were observed. Furthermore, a 3 cm -1 difference was noted in the bands of the main PO 4 3in rabbit's bone formed around the implant compared to the existing bone, suggesting a difference in the molecular structure between the existing and newly formed bone.