Comparative Evaluation of Azadirachta indica (Neem) Chip and Soft Tissue Diode Lasers as a Supplement to Phase I Periodontal Therapy in Localized Chronic Moderate Periodontitis: A Randomized Controlled Clinical Trial

Abstract

Introduction. The current trial aimed to assess and compare the efficacy of neem chip and diode laser as a local drug delivery (LDD) agent as a supplement to phase I periodontal therapy in treatment of localized chronic moderate periodontitis. Materials and Methodology. Fourteen systemically healthy participants with 4–6 mm deep periodontal pockets at least in three quadrants (with no alveolar bony defect amenable to respective or regenerative osseous surgery, as seen in orthopantomograph) were selected for the trial. One week after phase I therapy, 10% absorbable chip of neem (commercially prepared by staff of a pharmacy college, Sheriguda, India) was placed in the periodontal pocket on one site, and soft tissue diode laser pocket sterilization was performed on the other site of the arch. Remaining one site was considered as a control. Parameters recorded clinically were plaque index (PI), papillary bleeding index (PBI), probing pocket depth (PPD), and relative attachment level (RAL) measured at baseline, 21st day, and one month postoperatively. Results. Statistically significant improvements were observed in all clinical parameters at one month as compared to baseline for both treatment groups. Conclusion. Neem chip supplemented with phase I therapy showed best improvement in clinical parameters followed by laser supplemented with phase I therapy in comparison to phase I therapy alone at one month follow-up. Clinical Significance. Neem chips are nature’s products, affordable without side effects, with a potential to be used as a local drug delivery agent in treating moderate chronic periodontitis.

Platelet-Rich Fibrin in Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial

“…However, residual pockets after non-surgical therapy may require surgical intervention or tailored recall protocols to address lingering issues [31]. Therefore, different approaches have been proposed to improve the non-surgical periodontal treatment [17,24,32] and to achieve the closure of pockets deeper than 5 mm. One of the most interesting novel techniques is the application of PRF during SRP therapy [17], which likely contributes more than SRP alone.…”

Formulation of Neem and Echinacea Gel for Oral Health Along With the Evaluation of Antimicrobial, Cytotoxic, Anti-inflammatory, and Free Radical Scavenging Activity: An In Vitro Study

“…The acetone extracts of neem were more effective at inhibiting bacterial growth compared to aqueous extracts, which indicates the influence of solvents against bacteria [ 25 ]. Neem chips have been used in addition to scaling, and root planing demonstrated better results in both clinical and microbiological parameters [ 26 ]. Moreover, a clinical trial suggested that neem chips showed benefits in the treatment of periodontitis [ 27 ].…”

Comparative Evaluation of the Accuracy of Gingival Thickness Measurement by Clinical Evaluation and Intraoral Ultrasonography

“…In contrast, thick and flat biotypes with thicker gingiva and higher width of the keratinized gingiva are more commonly seen in dentition with wider and shorter crowns and higher interproximal contact areas [ 2 , 3 ]. Gingival thickness is an important component of gingival biotypes and plays a considerable role in the outcome of regenerative periodontal and implant treatments [ 4 , 5 , 6 , 7 ]. In addition to periodontal and implant procedures, gingival thickness also potentially affects the results of orthodontic and restorative treatments [ 8 , 9 ].…”