Comparative evaluation of autologous platelet‐rich fibrin and platelet‐rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial

Abstract

The use of autologous PRF or PRP were both effective in the treatment of furcation defects with uneventful healing of sites.

Management of Two-Wall Infra-Bony Defect with Platelet Rich Fibrin and Connective Tissue Graft Combination: A Case Report

“…Although the treated defect was partially supraalveolar and two-wall infrabony part was extending to the apex in combination with a buccal dehiscence, results of the exhibited twostep treatment revealed an obvious improvement of periodontal variables and this improvement might be associated with the positive effect of PRF to the cellular events during early healing period by its growth factor content. According to two randomized controlled clinical studies involving the evaluation of the effects of PRF in the surgical treatment of chronic periodontitis, enhanced healing of periodontal defect was found at sites treated with PRF than open flap debridement alone [23] and addition of PRF to porous hydroxyapatite graft increased observation of the regenerative effects [17]. In 2013, autologous PRF also added benefit to the clinical and radiographic outcomes including uneventful healing of the treated mandibular sites with type II furcation defects [23].…”

“…According to two randomized controlled clinical studies involving the evaluation of the effects of PRF in the surgical treatment of chronic periodontitis, enhanced healing of periodontal defect was found at sites treated with PRF than open flap debridement alone [23] and addition of PRF to porous hydroxyapatite graft increased observation of the regenerative effects [17]. In 2013, autologous PRF also added benefit to the clinical and radiographic outcomes including uneventful healing of the treated mandibular sites with type II furcation defects [23].…”

“…Just prior to CTG harvesting, 10 ml venous blood was collected and taken to the chair-side centrifuge for PRF preparation. PRF was prepared simultaneous with CTG harvesting procedure in accordance with the method described by Choukroun et al [15,18] and demonstrated in Figure 4. Briefly, 10 ml venous blood was collected from the antecubital vein into a sterile empty tube without anticoagulant and spun at 2700 rpm for 12 minutes in a standard chair-side centrifuge.…”

“…Periodontal regeneration is described as complete restoration of lost tissues including alveolar bone, periodontal ligament and cementum to their original architecture and regarded as ultimate goal of the periodontal therapy [2][3][4] Based on the knowledge about current regenerative procedures involving use of various biomaterials in addition to autogenous and allogenic bone grafts offer a 'limited' potential toward achieving a complete periodontal regeneration and today, there is not any single material available amount of the material and short handling duration can be counted as the main disadvantages. Use of PRF showed promising results in various periodontal surgical procedures such as treatment of infrabony and class II furcation defects and root coverage [15][16][17].…”

Manipulating fibrin structure of hematomas enhances large bone defects healing

“…Its effectiveness has been confirmed in small bone defect by using PRP to treat patients with mandibular degree II furcation defects (Bajaj et al, 2013). There are, however, no studies that unambiguously show that PRPs actually improve or accelerate bone healing in animal-based trials, such as rat cranial defect model (Plachokova et al, 2007), sheep mandibular defect model (Forriol et al, 2009), and sheep femoral osteotomy models (Hernandez-Fernandez et al, 2013).…”