Comparative Evaluation of Antipyretic Activity of Ibuprofen and Aspirin in Children with Pyrexia of Varied Aetiology

Abstract

The antipyretic activity of ibuprofen and aspirin was compared in sixteen children with pyrexia due to upper respiratory tract infection and in twelve with fever due to other causes. All 28 children received ibuprofen (7 mg/kg of body-weight) and aspirin (15 mg/kg of body-weight) in a single dose on 2 consecutive days in a crossover manner. Rectal temperature was recorded prior to and at regular intervals up to 8 hours after drug administration. Analysis of the results indicate that ibuprofen and aspirin effectively lower temperature and the two drugs are comparable in their antipyretic activity. In conclusion, significant antipyretic activity, good tolerance profile and availability in syrup form make ibuprofen a useful substitute for aspirin in children with fever.

Nonsteroidal anti‐inflammatory drugs in acute viral respiratory tract infections: An updated systematic review

“…In children, two studies reported GI adverse events. Barberi et al 33 reported a higher rate of GI adverse events (RR, 2.67; 95% CI, 0.77–9.23); and Kandoth 37 reported no events in either group. Both studies had very small sample sizes.…”

“…Nine studies investigated the efficacy of aspirin in ARTIs and the results are presented in Tables 6 and 7 . 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 …”

“…Three articles assessed fever reduction for aspirin and all showed a significant reduction of fever. 32 , 34 , 37 Broggini et al 34 reported a large effect in fever reduction in adults similar to flurbiprofen (MD, 0.1˚C; 95% CI, −0.32 to 0.12). Also, Bachert et al 32 reported that high‐dose aspirin reduced fever by 1.67˚C (95% CI, 1.53‐1.80).…”

“…Also, Bachert et al 32 reported that high-dose aspirin reduced fever by 1.67˚C (95% CI, 1.53-1.80). In the study by Kandoth et al, 37 although both aspirin and ibuprofen reduced fever by about 1˚C in children, the effects were more prominent for ibuprofen compared with aspirin (MD, 0.57˚C; 95% CI, 0.42-0.72).…”

Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics

“…Two open trials [12,13] showed that the effect of 6 mg/kg and 7 mg-kg-1 per dose of ibuprofen were no different from, respectively, 10 and 15 mg.kg -~ of aspirin. Several studies have compared the antipyretic effect of ibuprofen and acetaminophen [6][7][8][9][10][11].…”