Comparative Evaluation of Antifungal Activity of Melaleuca Oil and Fluconazole when Incorporated in Tissue Conditioner: An In Vitro Study

Sharma, Sanjita; Hegde, Veena

doi:10.1111/jopr.12117

Cited by 38 publications

(35 citation statements)

References 15 publications

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“…The experiments performed in this study confirm the results from previously published studies in that all of the tested fluconazole-resistant C. albicans strains were sensitive to TTO [ 14 , 15 , 28 , 29 ]. The determined TTO MICs were low, ranging from 0.06% to 0.5%.…”

Section: Discussionsupporting

confidence: 90%

The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-ResistantCandida albicansStrains

Mertas

Garbusińska

Szliszka

et al. 2015

BioMed Research International

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The aim of this study was to evaluate the activity of fluconazole against 32 clinical strains of fluconazole-resistant Candida albicans, and C. albicans ATCC 10231 reference strain, after their exposure to sublethal concentrations of tea tree oil (TTO) or its main bioactive component terpinen-4-ol. For all tested fluconazole-resistant C. albicans strains TTO and terpinen-4-ol minimal inhibitory concentrations (MICs) were low, ranging from 0.06% to 0.5%. The 24-hour exposure of fluconazole-resistant C. albicans strains to fluconazole with sublethal dose of TTO enhanced fluconazole activity against these strains. Overall, 62.5% of isolates were classified as susceptible, 25.0% exhibited intermediate susceptibility, and 12.5% were resistant. For all of the tested clinical strains the fluconazole MIC decreased from an average of 244.0 μg/mL to an average of 38.46 μg/mL, and the fluconazole minimal fungicidal concentrations (MFC) decreased from an average of 254.67 μg/mL to an average of 66.62 μg/mL. Terpinen-4-ol was found to be more active than TTO, and strongly enhanced fluconazole activity against fluconazole-resistant C. albicans strains. The results of this study demonstrate that combining natural substances such as TTO and conventional drug such as fluconazole, may help treat difficult yeast infections.

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Section: Discussionsupporting

confidence: 90%

The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-ResistantCandida albicansStrains

Mertas

Garbusińska

Szliszka

et al. 2015

BioMed Research International

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“…Denture stomatitis (DS) is an inflammatory disease that affects the oral mucosa underlying a removable dental prosthesis, both partial and total. DS is considered a very common disease affecting denture wearers, especially those with maxillary complete dentures [ 1 , 2 ]. Due to the strong relationship between DS and Candida fungus, the use of proper hygiene aids by the denture wearer is fundamental, by physical means, such as brushing, and, if necessary, chemical, and immersion of dentures in disinfectant solutions.…”

Section: Introductionmentioning

confidence: 99%

The Beneficial Effect ofEquisetum giganteumL. againstCandidaBiofilm Formation: New Approaches to Denture Stomatitis

Alavarce

Saldanha

Almeida

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Equisetum giganteum L. (E. giganteum), Equisetaceae, commonly called “giant horsetail,” is an endemic plant of Central and South America and is used in traditional medicine as diuretic and hemostatic in urinary disorders and in inflammatory conditions among other applications. The chemical composition of the extract EtOH 70% of E. giganteum has shown a clear presence of phenolic compounds derived from caffeic and ferulic acids and flavonoid heterosides derived from quercitin and kaempferol, in addition to styrylpyrones. E. giganteum, mainly at the highest concentrations, showed antimicrobial activity against the relevant microorganisms tested: Escherichia coli, Staphylococcus aureus, and Candida albicans. It also demonstrated antiadherent activity on C. albicans biofilms in an experimental model that is similar to dentures. Moreover, all concentrations tested showed anti-inflammatory activity. The extract did not show cytotoxicity in contact with human cells. These properties might qualify E. giganteum extract to be a promising alternative for the topic treatment and prevention of oral candidiasis and denture stomatitis.

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“…The most important issues include the development of resistance and recurrent infections. Currently, there is no "golden rule" for optimal therapy [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces

Géczi

Hermann

Kőhidai

et al. 2018

Journal of Nanomaterials

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To prepare an antimicrobial polymer composite composed of silver- (Ag-) polyethyleneimine- (PEI-) polylactic acid (PLA) in chloroform, for coating the mucosal surfaces of methacrylate-based dentures as a prospective therapy for denture stomatitis.The water-insoluble, tightly bound, hard, micrometre-thin, and colourless film exerts its effects by direct contact with the pathogens and via the active constituents (Ag, PEI, and Ag-PEI) released slowly into the mucosa’s salivary layer. Silver and PEI were blended at 140°C, then bound to PLA. The Ag-PEI complex was characterised by dynamic light scattering and transmission electron microscopy, and the Ag-PEI-PLA composite was examined by atomic force microscopy and micro-computed tomography. The characteristic was measured by atomic force microscopy (AFM) and micro-computed tomography (micro-CT). The quantity of water-soluble Ag-PEI complex released from the composite film was measured with gravimetry. The cellular physiological effects were analysed by impedimetry and computer-based morphometry using human gingival epithelial cells. A real-time cell proliferation assay revealed moderate toxic effects of Ag-PEI on the epithelium. The viscous Ag-PEI-PLA solution produced could be applied as a thin film on methacrylate surfaces. Active antimicrobial components (Ag, PEI, and Ag-PEI) were released from the hard, tightly bound Ag-PEI-PLA coating. This study’s findings verified the applicability of the antimicrobial Ag-PEI-PLA composite for coating the inner surfaces of acrylate dentures. Owing to the well-known antimicrobial effects of silver and PEI and the supplementary effects of chloroform, this composite provides a new therapeutic method for denture stomatitis that can be easily performed by dentists.

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Comparative Evaluation of Antifungal Activity of Melaleuca Oil and Fluconazole when Incorporated in Tissue Conditioner: An In Vitro Study

Cited by 38 publications

References 15 publications

The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-ResistantCandida albicansStrains

The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-ResistantCandida albicansStrains

The Beneficial Effect ofEquisetum giganteumL. againstCandidaBiofilm Formation: New Approaches to Denture Stomatitis

Antimicrobial Silver-Polyethyleneimine-Polylactic Acid Polymer Composite Film for Coating Methacrylate-Based Denture Surfaces

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