Comparative evaluation of antifungal action of tea tree oil, chlorhexidine gluconate and fluconazole on heat polymerized acrylic denture base resin – an <i>in vitro</i> study

Dalwai, Sameen; Rodrigues, Shobha J; Baliga, Shrikala; Shenoy, Vijaya; Shetty, Thilak; Pai, Umesh; Saldanha, Sharon

doi:10.1111/ger.12176

Cited by 24 publications

(25 citation statements)

References 31 publications

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“…The results of the present study show that TO and LO have antifungal effects against C. albicans, which has also been reported in other studies 11,[14][15][16][17][18][19] . However, LO were more effective than TO based on the MIC and MBC values, and consider that the differences in antifungal effect were related to the individual components of the essential oils.…”

Section: Discussionsupporting

confidence: 91%

“…Furthermore, several studies have reported that both TO and LO reduced biofilm formation on denture surface resin, and suggested their use for denture cleaning [17][18][19] . However, in clinical situations, many dentures with attached biofilm already developed are washed, though few reports have focused on removal of surface biofilm by use of an essential oil.…”

Section: Introductionmentioning

confidence: 99%

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Development of antibacterial denture cleaner for brushing containing tea tree and lemongrass essential oils

2018

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We evaluated effectiveness of tea tree oil (TO) and lemongrass oil (LO) for removal of Candida biofilm from denture base resin and their influence on that surface. Biofilm of C. albicans was formed on resins, and immersed in various concentrations of each oil and distilled water (DW). The biofilm removal effect was determined by incubating specimens in RPMI medium containing Alamar blue (AB) and measuring absorbance. Wear test was also conducted, and surface condition of resins was determined using laser scanning microscope and digital microscope. Specimens immersed in the TO and LO solutions tended to have a lower AB value at higher concentrations and longer soaking times. Use of these agents resulted in less surface roughness as compared to DW. Our results suggest that TO and LO were valid to remove biofilm attached to resin with lower levels of abrasion, and these are effective for use in denture cleaner.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Development of antibacterial denture cleaner for brushing containing tea tree and lemongrass essential oils

2018

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“…A widely prescribed mouth rinse, chlorhexidine has shown good clinical results as an alternative to conventional antifungal agents. [6,7] Chlorhexidine inhibits adhesion of Candida to oral and mucosal surfaces. It causes coagulation of nucleoproteins and also porosities in the cell wall, resulting in extrusion of cytoplasmic components.…”

Section: Discussionmentioning

confidence: 99%

“…[8] In an in vitro study, 0.2% chlorhexidine was found to be more effective than fluconazole in inhibiting growth of Candida albicans on heat-polymerized acrylic resins. [6] Another in vitro study showed chlorhexidine to have significant antifungal activity as compared to ketoconazole on Candida albicans isolated from children with early childhood caries. [7] The antifungal action of tulasi is due to its effect on the ergosterol biosynthesis pathway.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of tulasi extract mouthwash in the management of oral candidiasis

Annigeri¹,

Mangala²,

Thimmasetty³

et al. 2018

JCRI

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Aim:The aim of this study is to evaluate the efficacy of mouthwash containing tulasi (Ocimum sanctum) extract on oral candidiasis. Methodology: Minimum inhibitory concentration of tulasi extract was determined, and Tulasi mouthwash was prepared using 4% of the extract. A total of 90 patients with clinically diagnosed oral candidiasis were randomly allocated to chlorhexidine and tulasi groups. Pre-and post-oral symptoms such as burning sensation and altered taste were recorded using a VAS scale of 0-10. Patients were asked to rinse 10 mL of mouthwash thrice daily for 2-3 min for 7 days after food. Smear from oral candidal lesions before and after the treatment was taken, and colony-forming units (CFUs) were calculated. Results: The patients with oral candidiasis showed significant reduction in burning sensation and improvement in taste perception. CFU showed a significant reduction in both groups pre-and post-treatment. Tulasi showed statistically significant improvements over chlorhexidine. Conclusion: As tulasi was found to be more effective against oral candidiasis, it can be considered as viable substitute for synthetic drugs.

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“…All of them can be divided into two classes: released and non-released materials. For the released materials, early study indicated that tea tree oil and chlorhexidine gluconate were effective in inhibiting C. albicans growth on heat-polymerized acrylic resin and denture soft liner [13,16]. The denture base resin containing nano-silver showed antifungal activity and an inhibitory effect on adhesion and biofilm formation of C. albicans , especially at a higher concentration [17].…”

Section: Introductionmentioning

confidence: 99%

Heat-Polymerized Resin Containing Dimethylaminododecyl Methacrylate Inhibits Candida albicans Biofilm

et al. 2017

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The prevalence of stomatitis, especially caused by Candida albicans, has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (w/w). Flexure strength, bond quality, surface charge density, and surface roughness were measured to evaluate the physical properties of resin. The specimens were incubated with C. albicans solution in medium to form biofilms. Then Colony-Forming Units, XTT assay, and scanning electron microscope were used to evaluate antifungal effect of DMADDM-modified resin. DMADDM modified acrylic resin had no effect on the flexural strength, bond quality, and surface roughness, but it increased the surface charge density significantly. Meanwhile, this new resin inhibited the C. albicans biofilm significantly according to the XTT assay and CFU counting. The hyphae in C. albicans biofilm also reduced in DMADDM-containing groups observed by SEM. DMADDM modified acrylic resin was effective in the inhibition of C. albicans biofilm with good physical properties.

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Comparative evaluation of antifungal action of tea tree oil, chlorhexidine gluconate and fluconazole on heat polymerized acrylic denture base resin – an in vitro study

Abstract: Tea tree oil and chlorhexidine gluconate are more effective than fluconazole in inhibiting C. albicans growth on heat-polymerised acrylic resin.

Cited by 24 publications

References 31 publications

Development of antibacterial denture cleaner for brushing containing tea tree and lemongrass essential oils

Development of antibacterial denture cleaner for brushing containing tea tree and lemongrass essential oils

Evaluation of tulasi extract mouthwash in the management of oral candidiasis

Heat-Polymerized Resin Containing Dimethylaminododecyl Methacrylate Inhibits Candida albicans Biofilm

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