Comparative evaluation of a live E. coli vaccine and cefotaxime treatment against three E. coli serotypes in broilers

Elbestawy, Ahmed R.; Ellakany, Hany F.; El-Hamid, Hatem S. Abd; Ibrahim, Madiha S.; Gado, Ahmed R.; Mustafa, Nagwa S.; Moussa, Ihab M.; Almaary, Khalid S.; Al-Sarar, Dalia; Dawoud, Turki M.; Hemeg, Hassan A.; Galal, Hussein M.

doi:10.1016/j.jksus.2021.101353

Cited by 2 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oral vaccination of birds at day 5 of age reduced morbidity [59] but drinking water application was found to be ineffective in inducing protection [56]. The findings regarding heterologous protection were not consistent among studies with some showing effectiveness against certain strains [54,60], but not others [56,57,60]. The efficacy of the vaccine against homologous challenge was enhanced by supplementation of probiotics Enterococcus faecalis [58] and pre-treatment with Lincospectin improved the vaccine's response [61].…”

Section: Live and Live Attenuated Vaccinesmentioning

confidence: 99%

“…Developing an effective vaccine against colibacillosis in chickens is complex due to the high heterogenicity of E. coli isolates, elusive disease mechanisms, and absence of definitive markers for pathogenic isolates [17,20]. This complexity is evident in the limited number of vaccines reaching the commercial market, with conflicting reports about their effectiveness [53,60].…”

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

Paudel,

Apostolakos,

Vougat Ngom

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Colibacillosis, a disease caused by Escherichia coli in broiler chickens has serious implications on food safety, security, and economic sustainability. Antibiotics are required for treating the disease, while vaccination and biosecurity are used for its prevention. This systematic review and meta-analysis, conducted under the COST Action CA18217—European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT), aimed to assess the efficacy of E. coli vaccination in broiler production and provide evidence-based recommendations. A comprehensive search of bibliographic databases, including, PubMed, CAB Abstracts, Web of Science and Agricola, yielded 2,722 articles. Following a defined protocol, 39 studies were selected for data extraction. Most of the studies were experimental infection trials, with only three field studies identified, underscoring the need for more field-based research. The selected studies reported various types of vaccines, including killed (n = 5), subunit (n = 8), outer membrane vesicles/protein-based (n = 4), live/live-attenuated (n = 16), and CpG oligodeoxynucleotides (ODN) (n = 6) vaccines. The risk of bias assessment revealed that a significant proportion of studies reporting mortality (92.3%) or feed conversion ratio (94.8%) as outcomes, had “unclear” regarding bias. The meta-analysis, focused on live-attenuated and CpG ODN vaccines, demonstrated a significant trend favoring both vaccination types in reducing mortality. However, the review also highlighted the challenges in reproducing colibacillosis in experimental setups, due to considerable variation in challenge models involving different routes of infection, predisposing factors, and challenge doses. This highlights the need for standardizing the challenge model to facilitate comparisons between studies and ensure consistent evaluation of vaccine candidates. While progress has been made in the development of E. coli vaccines for broilers, further research is needed to address concerns such as limited heterologous protection, practicability for application, evaluation of efficacy in field conditions and adoption of novel approaches.

show abstract

Section: Live and Live Attenuated Vaccinesmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

Paudel,

Apostolakos,

Vougat Ngom

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Lozica et al [ 81 ] reported that an autonomous E. coli vaccine significantly reduced morbidity and mortality and increased egg production in poultry. Several studies showed that an E. coli vaccine, Poulvac® (Zoetis, Parsippany, NJ, USA) effectively worked against the avian pathogenic E. coli in poultry [ 82 , 83 , 84 , 85 , 86 , 87 ].…”

Section: A Review Of Current Research Studies On the Efficacy Of Bact...mentioning

confidence: 99%

A Comprehensive Review on Bacterial Vaccines Combating Antimicrobial Resistance in Poultry

Islam

Rahman

2023

Vaccines

View full text Add to dashboard Cite

Bacterial vaccines have become a crucial tool in combating antimicrobial resistance (AMR) in poultry. The overuse and misuse of antibiotics in poultry farming have led to the development of AMR, which is a growing public health concern. Bacterial vaccines are alternative methods for controlling bacterial diseases in poultry, reducing the need for antibiotics and improving animal welfare. These vaccines come in different forms including live attenuated, killed, and recombinant vaccines, and they work by stimulating the immune system to produce a specific response to the target bacteria. There are many advantages to using bacterial vaccines in poultry, including reduced use of antibiotics, improved animal welfare, and increased profitability. However, there are also limitations such as vaccine efficacy and availability. The use of bacterial vaccines in poultry is regulated by various governmental bodies and there are economic considerations to be taken into account, including costs and return on investment. The future prospects for bacterial vaccines in poultry are promising, with advancements in genetic engineering and vaccine formulation, and they have the potential to improve the sustainability of the poultry industry. In conclusion, bacterial vaccines are essential in combating AMR in poultry and represent a crucial step towards a more sustainable and responsible approach to poultry farming.

show abstract

Comparative evaluation of a live E. coli vaccine and cefotaxime treatment against three E. coli serotypes in broilers

Cited by 2 publications

References 21 publications

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

A Comprehensive Review on Bacterial Vaccines Combating Antimicrobial Resistance in Poultry

Contact Info

Product

Resources

About