Comparative Evaluation and Correlation of Periodontal Status With Inflammatory Markers in Pregnant Women With or Without Chronic Periodontitis: A Clinico-Hematological Study

Abstract

Background The research delves into the intricate relationship between periodontal health and specific blood biomarkers in pregnant women during their second trimester. It specifically focuses on the levels of interleukin-6 (IL-6), lactate dehydrogenase (LDH), and C-reactive protein (CRP) in those suffering from chronic periodontitis compared to healthy controls. Methodology A detailed approach was taken involving 60 pregnant women categorized into two groups based on the presence or absence of chronic periodontitis. Out of 60 pregnant women, 30 had chronic periodontitis, while the other 30 served as controls selected from the regular patient population of the college. The study utilized blood sample analysis and advanced statistical tools for data analysis, ensuring precise and reliable results. Levels of IL-6, LDH, and CRP in those suffering from chronic periodontitis compared to healthy controls were checked. Results The findings revealed a notable variance in IL-6, LDH, and CRP levels between the two groups. Women with chronic periodontitis exhibited significantly higher levels of these biomarkers. The statistical analysis reinforced the validity of these differences, highlighting their significance. Conclusions The study underscored a clear link between higher levels of IL-6, LDH, and CRP and the presence of chronic periodontitis in pregnant women. These biomarkers emerge as potential indicators for early detection and monitoring of periodontal health in this demographic.

The Bloody Crossroads: Interactions between Periodontitis and Hematologic Diseases

“…Pregnant women with chronic periodontitis exhibit higher levels of inflammatory markers compared to those without the condition. This study underscores the importance of periodontal health monitoring in pregnancy to prevent systemic inflammation [126] Given the complexity and differential impact of hematologic disorders on oral health, especially periodontal disease, a comprehensive understanding requires examination of both the direct and indirect effects of these systemic diseases on the oral microbiota, immune response, and tissue integrity. Hematologic disorders, including anemias, leukemias, and lymphomas, can significantly alter the host immune system, making the oral cavity more susceptible to periodontal pathogens and exacerbating the severity of periodontal disease.…”

“…Pregnant women with chronic periodontitis exhibit higher levels of inflammatory markers compared to those without the condition. This study underscores the importance of periodontal health monitoring in pregnancy to prevent systemic inflammation [ 126 ]…”