Comparative Electrochemical Investigation of Pt, Au and Ti Electrodes on Liquid Crystal Polymer for the Application of Neuromuscular Prostheses

Mohtashami, Saba; Howlader, Matiar R.; Doyle, Thomas E.

doi:10.1149/1.3646929

Cited by 10 publications

(5 citation statements)

References 21 publications

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“…The thermoplasticity of LCP can be utilized to create a non-planar structure for conformation to target tissues by a simple thermoforming process, and to rapidly form a multilayered structure by stacking independently prepared LCP layers and thermally pressing them to bond together. The potential of LCP has been demonstrated in wide range of applications in neural engineering such as a miniaturized all-LCP retinal implant with an eye-conformable structure [125] as well as various shapes of neural electrode arrays for cortical [126,127], cochlear [128,129], intraocular [130,131,132], and peripheral applications [133,134,135].…”

Section: Organic Materialsmentioning

confidence: 99%

Emerging Encapsulation Technologies for Long-Term Reliability of Microfabricated Implantable Devices

2019

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The development of reliable long-term encapsulation technologies for implantable biomedical devices is of paramount importance for the safe and stable operation of implants in the body over a period of several decades. Conventional technologies based on titanium or ceramic packaging, however, are not suitable for encapsulating microfabricated devices due to their limited scalability, incompatibility with microfabrication processes, and difficulties with miniaturization. A variety of emerging materials have been proposed for encapsulation of microfabricated implants, including thin-film inorganic coatings of Al2O3, HfO2, SiO2, SiC, and diamond, as well as organic polymers of polyimide, parylene, liquid crystal polymer, silicone elastomer, SU-8, and cyclic olefin copolymer. While none of these materials have yet been proven to be as hermetic as conventional metal packages nor widely used in regulatory approved devices for chronic implantation, a number of studies have demonstrated promising outcomes on their long-term encapsulation performance through a multitude of fabrication and testing methodologies. The present review article aims to provide a comprehensive, up-to-date overview of the long-term encapsulation performance of these emerging materials with a specific focus on publications that have quantitatively estimated the lifetime of encapsulation technologies in aqueous environments.

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Section: Organic Materialsmentioning

confidence: 99%

Emerging Encapsulation Technologies for Long-Term Reliability of Microfabricated Implantable Devices

2019

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“…In this study, we developed a retinal prosthesis device for implantation comprising a bioceramic substrate with Pt electrodes, 37,38) a CMOS chip, and flexible parylene C thinfilm substrate connecting each bioceramic substrate. As shown in Fig.…”

Section: Design and Assembly Of The Retinal Devicementioning

confidence: 99%

A flexible retinal device with CMOS smart electrodes fabricated on parylene C thin-film and bioceramic substrate

Pan

Hagiwara

Tso

et al. 2023

Jpn. J. Appl. Phys.

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We developed implementation technologies for artificial vision devices compatible with suprachoroidal transretinal stimulation. We aimed to develop a device that can be safely implanted in the sclera of the eye for a long period. Using parylene C and bioceramics as biocompatible base materials, we realized a device with high in vivo safety by making the device structure flexible and reducing the wires of control signals. We successfully created a prototype device that combines a flexible wire structure based on a parylene C thin film with a wire-saving CMOS smart electrode structure based on CMOS integrated circuits. We conducted in vitro and in vivo experiments to confirm their performances. The immersion test confirmed that the device could work normally for four days. Furthermore, in the in vivo experiments using rat, we successfully measured evoked potentials in the brain induced by the stimulation current using the device.

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“…It was first proposed by Randles in 1947 to study electrode reaction speed [1]. Since then, it has become a widely accepted model in fields such as characterizing the electrochemical properties of materials and interfaces [2]- [4], as well as for fuel cells [5], solar cells [6], prosthesis [7], and even various types of sensors such as liquid conductivity [8] or biological sensors [9].…”

Section: Introductionmentioning

confidence: 99%

A Simple Method for a Digital Readout of Randles Impedances

Hidalgo-López

2024

IEEE Trans. Instrum. Meas.

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The Randles Impedance Model (RIM) characterizes a wide range of physical phenomena. The model comprises three elements: a resistor in series with a combination of a capacitor and another resistor arranged in parallel. This structure makes determining RIM component values particularly complex. Although such values can be found using Electrical Impedance Spectroscopy (EIS), this process requires a large number of measurements and complex hardware. Other time-based methods reduce the number of measurements, but the hardware involved is still excessive for a portable system, requiring complicated arithmetic calculations that may produce less than accurate results. This paper presents a readout method based on time measurements that uses only a simple digital processor, DP (without analog-to-digital converters), and two resistors of known value to estimate the RIM parameters in digital format. The method performs three Randles impedance capacitor chargedischarge processes to obtain five time measurements. The results are found by processing the time measurements in the DP using simple arithmetical operations. Despite the simplicity of both the hardware and the reading and calculation methods, errors in the estimates of a range of RIM parameter combinations are among the lowest in the literature, varying between 1.22% and 1.66%, depending on the parameter to be estimated.

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Comparative Electrochemical Investigation of Pt, Au and Ti Electrodes on Liquid Crystal Polymer for the Application of Neuromuscular Prostheses

Cited by 10 publications

References 21 publications

Emerging Encapsulation Technologies for Long-Term Reliability of Microfabricated Implantable Devices

Emerging Encapsulation Technologies for Long-Term Reliability of Microfabricated Implantable Devices

A flexible retinal device with CMOS smart electrodes fabricated on parylene C thin-film and bioceramic substrate

A Simple Method for a Digital Readout of Randles Impedances

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