Comparative efficacy of three indexes of left ventricular performance derived from pressure-volume loops in heart failure induced by tachypacing

Rahko, Peter S.

doi:10.1016/0735-1097(94)90522-3

Cited by 33 publications

(24 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, also, for these parameters, load-dependence and inotropic sensitivity vary. In the majority of the methodological studies reported in the literature, either contractile sensitivity or load dependence was investigated in a certain experimental setting [7,19,22,32,33]. Only in a few studies was the comparative influence of load and contractility on the contractile parameters measured [14,16,29].…”

Section: Introductionmentioning

confidence: 98%

Parameters of ventricular contractility in mice: influence of load and sensitivity to changes in inotropic state

Bergh

Flameng

Herijgers

2007

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

We examined the relative usefulness of parameters to determine left ventricular contractility in mice invasively. The optimal parameter must be sensitive to changes in inotropy and insensitive to changes in loading. Furthermore, it should be able to confirm or reject the hypothesis of altered myocardial contractility after a limited number of experiments. Left ventricular function was assessed in closed-chest mice using a microtip pressure-conductance catheter at baseline and after increases in preload, afterload, or contractility. The parameters are differentially influenced by loading conditions and inotropic state. Only those parameters that could differentiate between basal and increased contractility with a power of 0.85 in ten or less experiments were considered useful. Ejection fraction, preload-recruitable stroke work (PRSW), and dP/dt(max)/V (ed) could demonstrate the smallest changes in contractility. Stroke work, maximal power and dP/dt(max) were most influenced by preload. End-systolic elastance, ejection fraction, and stroke work were afterload-dependent. Dividing the magnitude of the effect of inotropic stimulation to that of load changes gives an index for the usefulness for each parameter. A high ratio indicates that the change in parameter reflects inotropic rather than load change. This ratio was highest for PRSW, which seems to be the best parameter for judging contractility differences in mice.

show abstract

Section: Introductionmentioning

confidence: 98%

Parameters of ventricular contractility in mice: influence of load and sensitivity to changes in inotropic state

Bergh

Flameng

Herijgers

2007

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

show abstract

“…Contractility was indexed by peak ϩdP/dt and the load-independent parameters preload-recruitable stroke work (PRSW; slope of stroke work [SW]/end-diastolic dimension relation), and ventricular elastance (Ees; slope of the end-systolic pressure dimension or volume relation). 31,33,34 Diastolic performance was measured by peak -dP/dt, time to peak filling rate (ttpf), and time constant of relaxation (tau). 35 Myocardial oxygen consumption per unit time (MV O 2 ) in the left circumflex artery territory was calculated from the difference in arteriovenous oxygen saturation (AVO 2 ) in simultaneously sampled coronary sinus and aortic blood, multiplied by left circumflex coronary blood flow.…”

Section: Hemodynamic and Energetic Data Analysismentioning

confidence: 99%

Intravenous Allopurinol Decreases Myocardial Oxygen Consumption and Increases Mechanical Efficiency in Dogs With Pacing-Induced Heart Failure

Ekelund

Harrison

Shokek

et al. 1999

Circulation Research

214

163

View full text Add to dashboard Cite

Abstract-Allopurinol, an inhibitor of xanthine oxidase, increases myofilament calcium responsiveness and blunts calcium cycling in isolated cardiac muscle. We sought to extend these observations to conscious dogs with and without pacing-induced heart failure and tested the prediction that allopurinol would have a positive inotropic effect without increasing energy expenditure, thereby increasing mechanical efficiency. In control dogs (nϭ10), allopurinol (200 mg IV) caused a small positive inotropic effect; (dP/dt) max increased from 3103Ϯ162 to 3373Ϯ225 mm Hg/s (ϩ8.3Ϯ3.2%; Pϭ0.01), but preload-recruitable stroke work and ventricular elastance did not change. In heart failure (nϭ5), this effect was larger; (dP/dt) max rose from 1602Ϯ190 to 1988Ϯ251 mm Hg/s (ϩ24.4Ϯ8.7%; Pϭ0.03), preload-recruitable stroke work increased from 55.8Ϯ9.1 to 84.9Ϯ12.2 mm Hg (ϩ28.1Ϯ5.3%; Pϭ0.02), and ventricular elastance rose from 6.0Ϯ1.6 to 10.5Ϯ2.2 mm Hg/mm (Pϭ0.03). Allopurinol did not affect myocardial lusitropic properties either in control or heart failure dogs. In heart failure dogs, but not controls, allopurinol decreased myocardial oxygen consumption (-49Ϯ4.6%; Pϭ0.002) and substantially increased mechanical efficiency (stroke work/myocardial oxygen consumption; ϩ122Ϯ42%; Pϭ0.04). Moreover, xanthine oxidase activity was Ϸ4-fold increased in failing versus control dog hearts (387Ϯ125 versus 78Ϯ72 pmol/min ⅐ mg -1 ; Pϭ0.04) but was not detectable in plasma. These data indicate that allopurinol possesses unique inotropic properties, increasing myocardial contractility while simultaneously reducing cardiac energy requirements. The resultant boost in myocardial contractile efficiency may prove beneficial in the treatment of congestive heart failure. (Circ Res. 1999;85:437-445.)

show abstract

“…This parameter is not preload dependent and has been validated to closely approximate total afterload, which incorporates systemic vascular resistance, aortic impedance, and the reflected wave properties of the vasculature. Myocardial contractility was indexed by the peak rate of rise in LV pressure (+dP/dt) divided by instantaneous pressure (dP/dt-IP) (29) and the load-independent end-systolic elastance (Ees) (30,31). Ees is the slope of the end-systolic pressure-volume relationship (ESPVR).…”

mentioning

confidence: 99%

β3-adrenoceptor deficiency blocks nitric oxide–dependent inhibition of myocardial contractility

Varghese¹,

Harrison²,

Lofthouse³

et al. 2000

J. Clin. Invest.

121

View full text Add to dashboard Cite

Comparative efficacy of three indexes of left ventricular performance derived from pressure-volume loops in heart failure induced by tachypacing

Cited by 33 publications

References 32 publications

Parameters of ventricular contractility in mice: influence of load and sensitivity to changes in inotropic state

Parameters of ventricular contractility in mice: influence of load and sensitivity to changes in inotropic state

Intravenous Allopurinol Decreases Myocardial Oxygen Consumption and Increases Mechanical Efficiency in Dogs With Pacing-Induced Heart Failure

β3-adrenoceptor deficiency blocks nitric oxide–dependent inhibition of myocardial contractility

Contact Info

Product

Resources

About