Comparative Efficacy of Serum Creatinine and Microalbuminuria in Detecting Early Renal Injury in Asphyxiated Babies in Calabar, Nigeria

Abstract

Background: Microalbuminuria and serum creatinine are markers of acute kidney injury. Birth asphyxia is responsible for 50% of all newborn deaths and acute non-oliguric kidney injury is one of such complications. This study was undertaken to determine the efficacy of serum creatinine and microalbuminuria for the detection of early renal lesion in severely asphyxiated babies in Calabar, Nigeria. Materials and Method: This prospective cross-sectional investigational study was undertaken among severely asphyxiated babies admitted into the newborn units of the University of Calabar Teaching Hospital (UCTH), Calabar, Nigeria. Standard method for blood collection and determination of urea, electrolytes were used. Micral-test strips were used on samples negative only for albumin after using urine dipstick. Color comparison was done with the standardized color scale on test strip container after 5 minutes. Results: Fifty term newborn babies were enrolled, their serum electrolytes, creatinine and creatinine clearance were essentially normal. Six (12%) babies had positive microalbuminuria, while 44(88%) had negative microalbuminuria with specificity and negative predictive values of 100% and 88% respectively. Conclusion: Microalbuminuria was not useful for early detection of acute renal failure in babies with severe birth asphyxia, but further studies are recommended.

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

“…1 2 1 1 In SCD, microalbuminuria is one of the most common clinical manifestations of sickle cell nephropathy (SCN) [4][5], which appears to be associated with a more rapid deterioration in renal function [6]. The reported incidence of microalbuminuria in children with SCD ranges from 18.4% to 46% [7][8][9]. The identification of microalbuminuria in a patient with SCD is a predictor of end-organ disease, including renal damage [10][11].…”

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease in the King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

“…15 Varied incidence of microalbuminuria in children with SCD ranges from 18.4% to 46%. [16][17][18] The identification of risk factors for microalbuminuria may allow earlier intervention to prevent renal complications. 16 Considering the high burden of SCD in the KSA with a prevalence rate of 2.6% in newborns 1 in a population of >24 million, children with SCD are prone to developing microalbuminuria and chronic renal failure with advancing age.…”

Prevalence and Risk Factors for Microalbuminuria in Children with Sickle Cell Disease at King Abdulaziz University Hospital: A Retrospective Cross-sectional Study

“…9 The reported incidence of microalbuminuria in children with SCD ranges from 18.4% to 46%. [16][17][18] The identi cation of microalbuminuria in a patient with SCD is a predictor of end-organ disease, including renal damage. 10,11 Children with SCD experience hyper ltration and hyperperfusion, which are associated with renal damage.…”