Comparative efficacy of pure yellow (577-nm) and 810-nm subthreshold micropulse laser photocoagulation combined with yellow (561–577-nm) direct photocoagulation for diabetic macular edema

Inagaki, Keiji; Ohkoshi, Kishiko; Ohde, Sachiko; Deshpande, Gautam A.; Ebihara, Nobuyuki; Murakami, Akira

doi:10.1007/s10384-014-0361-1

Cited by 69 publications

(35 citation statements)

References 20 publications

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“…Additionally, vitreal VEGF levels have been shown to decrease after PPV [24] [25][26]. In our study, 15 patients received intraoperative laser photocoagulation which can lead to decrease in retinal thickness[27] [28]. The decrease of CBT in our study can be a result from a combination of effects of 1) decreased intravitreal VEGEF concentration after vitrectomy, 2) application of anti-VEGEF be-fore operation and 3) laser photocoagulation during operation.Marigo et al evaluated anterior segment morphology with UBM before vitrectomyoperation and one month after operation in a study group consisting of 20 patients.…”

mentioning

confidence: 67%

Evaluation of the Changes in Anterior Segment Morphology with Ultrasound Biomicroscopy after Vitrectomy without Use of Tamponade in Pseudophakic Eyes

Unsal¹,

Eltutar²

2016

OJOph

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Aim: In this study we investigated the changes in anterior segment morphology in pseudophakia patients that underwent ultrasound biomicroscopy (UBM) after pars plana vitrectomy (PPV) operation without use of tamponade. Method: Pseudophakic patients who undergo PPV were enrolled in this prospective study between October 2012 and April 2015. Study included patients in whom intraocular tamponade was not used during PPV operation. UBM measurements were performed both before and 10 days after the operation. Anterior chamber depth (ACD) was measured using axial images of anterior segment. Trabecular meshwork-iris angle (TIA), ciliary body thickness (CBT), sclera thickness (ST), trabecular meshwork-ciliary process distance (T-CPD), iris-ciliary processes distance (I-CPD), and iris thickness (IT) were measured at temporal quadrant based on radial section images of the angle. Values measured before and after the operation were statistically compared with each other. Results: This study included 30 patients (18 females, 12 males) that underwent an operation ultrasound biomicroscopy (UBM) after pars plana vitrectomy (PPV) operation without use of tamponade. Mean age was 69.6 ± 9.1 (55 -85) years. Eighteen operations occurred on the left eye whereas twelve operations occurred on the right eye. CBT1, CBT2, CBT Max, T-CPD, and I-CPD were significantly decreased after operation when compared with the values of baseline (before) (p = 0.018, p = 0.012, p = 0.001, p = 0.033, p = 0.015, respectively). Other evaluated parameters did not show statistically significant changes after the operation (p > 0.05). Discussion: PPV results in significant changes in ciliary body morphology together with changes in anterior segment parameters in pseudophakic cases.

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mentioning

confidence: 67%

Evaluation of the Changes in Anterior Segment Morphology with Ultrasound Biomicroscopy after Vitrectomy without Use of Tamponade in Pseudophakic Eyes

Unsal¹,

Eltutar²

2016

OJOph

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“…In a recent prospective, single-center 6-month cohort study of patients with DME, there were no clinically visible scars seen following treatment with micropulse yellow or infrared laser using lowest duty cycle (5 %) [33]. Sub-threshold micropulse laser has shown promising efficacy in the direct treatment of microaneurysms in DME [34].…”

Section: Laser Therapy For Diabetic Macular Edemamentioning

confidence: 98%

Novel Therapies in Development for Diabetic Macular Edema

et al. 2015

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Diabetic macular edema (DME) secondary to diabetic retinopathy (DR) is a major cause for functional visual loss in the developed world. Laser photocoagulation has been used for decades in the treatment of DME. However, the advent of anti-vascular endothelial growth factor (anti-VEGF) has revolutionized the treatment of DME. Three important anti-VEGF agents whose efficacy has been well established via phase III clinical trials include ranibizumab, bevacizumab, and aflibercept. However, even in the era of anti-VEGF therapies, there are some challenges that retina specialists have to confront in managing patients with DME. These include the need for frequent treatment and an unpredictable response to therapy. There is evidence to suggest that pathways other than the VEGF pathway may be playing a role in the development of DME. Thus, extensive research is focused on development of novel agents that target these pathways. This review focuses on novel therapeutic agents in development, which may be used as a monotherapy or in combination with anti-VEGF agents, for the management of DME in the future.

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“…However, the higher selectivity of 577 nm light makes it possible to achieve the same therapeutic effect but at the same time decrease the damage to surrounding tissue. For this reason 577 nm has been investigated for, e.g., opthalmology 1,2 . Yellow lasers are also suitable for flow cytometry 3 because they can used to selectively excite certain fluorophores.…”

Section: Introductionmentioning

confidence: 99%

Diffraction-limited 577 nm true-yellow laser by frequency doubling of a tapered diode laser

Christensen¹,

Vilera

Noordegraaf³

et al. 2018

Nonlinear Frequency Generation and Conversion: Materials and Devices XVII

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A wide range of laser medical treatments are based on coagulation of blood by absorption of the laser radiation. It has, therefore, always been a goal of these treatments to maximize the ratio of absorption in the blood to that in the surrounding tissue. For this purpose lasers at 577 nm are ideal since this wavelength is at the peak of the absorption in oxygenated hemoglobin. Furthermore, 577 nm has a lower absorption in melanin when compared to green wavelengths (515 -532 nm), giving it an advantage when treating at greater penetration depth. Here we present a laser system based on frequency doubling of an 1154 nm Distributed Bragg Reflector (DBR) tapered diode laser, emitting 1.1 W of single frequency and diffraction limited yellow light at 577 nm, corresponding to a conversion efficiency of 30.5%. The frequency doubling is performed in a single pass configuration using a cascade of two bulk non-linear crystals. The system is power stabilized over 10 hours with a standard deviation of 0.13% and the relative intensity noise is measured to be 0.064 % rms.

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Comparative efficacy of pure yellow (577-nm) and 810-nm subthreshold micropulse laser photocoagulation combined with yellow (561–577-nm) direct photocoagulation for diabetic macular edema

Cited by 69 publications

References 20 publications

Evaluation of the Changes in Anterior Segment Morphology with Ultrasound Biomicroscopy after Vitrectomy without Use of Tamponade in Pseudophakic Eyes

Evaluation of the Changes in Anterior Segment Morphology with Ultrasound Biomicroscopy after Vitrectomy without Use of Tamponade in Pseudophakic Eyes

Novel Therapies in Development for Diabetic Macular Edema

Diffraction-limited 577 nm true-yellow laser by frequency doubling of a tapered diode laser

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