Comparative Efficacy of Positron Emission Tomography With Fluorodeoxyglucose in Evaluation of Small (&lt;1 cm), Intermediate (1 to 3 cm), and Large (&gt;3 cm) Lymph Node Lesions

Gupta, Naresh; Graeber, Geoffrey M.; Bishop, Harry A.

doi:10.1378/chest.117.3.773

Cited by 192 publications

(100 citation statements)

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“…Several studies demonstrated that there are 12-17% of N2 positive patients who preoperatively diagnosed as N0 (4,14,15). And FDG-PET proved significantly more accurate than CT in demonstrating and staging of nodal involvement (12,13). Recently, the technique of perioperative sentinel node mapping, which can identify nodal involvement at the first lymphatic drainage site, has been developed, and this is expected to detect metastatic lymph nodes of the mediastinum with a high accuracy rate (21,22).…”

Section: Discussionmentioning

confidence: 99%

“…Accuracy of CT in preoperative mediastinal lymph node staging was 45 to 79% (11)(12)(13)(14)(15). Recently, cervical mediastinoscopy or positron emission tomography (PET) scanning with 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG) proved more accurate than computed tomography (CT) in demonstration and staging of nodal involvement (11)(12)(13). However, advancements in CT have been allowing us to detect more detailed information and CT is still widely used for assessment of mediastinal involvement.…”

Section: Effect Of Mediastinal Lymph Nodes Sampling In Patients With mentioning

confidence: 99%

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Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

et al. 2008

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:Objective : Systematic nodal dissection has been recommended for patients with resectable non-small cell lung cancer because of its staging accuracy. However, in patients with clinical stage I non-small cell lung cancer whether systematic nodal dissection provides more benefits than mediastinal lymph node sampling or not is controversial. In this retrospective study, we evaluated the effect of mediastinal lymph node sampling in patients with clinical stage I NSCLC. Methods : One hundred and nineteen consecutive patients with clinical stage I NSCLC, who underwent curative operation between January 1994 and December 2000, were retrospectively reviewed (dissection group = 58 : sampling group= 61). Systematic nodal dissection was defined as complete removal of mediastinal lymph node, and mediastinal lymph node sampling was defined as removal of lymph node levels 3, 4, and 7 for right-sided tumors and levels 5, 6, and 7 for left-sided tumors. Results : The total number of removed mediastinal lymph nodes in patients who underwent systematic nodal dissection was 22.1 9.7, which was significantly higher than that in patients who underwent mediastinal lymph node sampling of 11.4 7.0 (p 0.001). Postoperatively N2 disease was detected in 8 patients (13.8% %) in the dissection group and 7 (11.5% %) in the sampling group. After the median follow up of 79 months, the cancer specific survival rate at 5 year was 78.0% % in the dissection group and 76.2% % in the sampling group (p = 0.60). Conclusions : Mediastinal lymph node sampling showed the similar effect to systematic nodal dissection in patients with clinical stage I non-small cell lung cancer. J. Med. Invest. 55 : 37-43, February, 2008

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Mediastinal Lymph Nodes Sampling In Patients With mentioning

confidence: 99%

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

et al. 2008

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“…As malignant tumors have more metabolic activity than the surrounding normal tissue, they appear as enhancing lesions on PET scan. However, even some inflammatory masses can be seen as enhancing lesions in PET scan thus giving a false positive result 5 . In this case, PET scan revealed significant uptake in a pyonephrotic kidney, leading to the assumption of a neoplastic mass.…”

Section: Discussionmentioning

confidence: 99%

PET scan Misleads to Diagnosis but Leads to Correct Operative Approach

Badhe¹

2017

jmscr

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“…In a prospective study with 102 patients, the sensitivity and specificity of FDG-PET in the detection of mediastinal lymph node metastases was found to be 91% and 86% respectively [12]. The main advantages of FDG-PET are its ability to detect metastatic lypmh nodes smaller than 1 cm in size and its high negative predicitive value [13,14].…”

Section: Discussionmentioning

confidence: 99%

Comparison of diffusion weighted MRI parameters of mediastinal lymph nodes with PET/CT in lung cancer patients

Bugdayci¹,

Kodalli²,

Dede³

et al. 2014

MMJ

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Objective:We have compared diffusion-weighted magnetic resonance imaging (DW-MRI) properties of mediastinal lymph nodes in lung cancer patients with positron emission tomography/ computed tomography (PET/CT) findings.Patients and Methods: Twenty-one consecutive untreated patients with lung cancer were included. DW-MRI was performed on a 1,5T scanner with b values of 50, 500 and 1000. Additional MR imaging was performed for anatomical correlation.Results: A total of 47 lymph nodes were analyzed. While no correlation was found between minimum apparent diffusion coefficient (ADC) values (ADCmin) of lymph nodes and their maximum standardized uptake values (SUVmax) on PET/CT, ADCmin ratios of lymph nodes to main lesion (ADCmin Node/ Lesion) (r = -0.407; p = 0.005) and lymph node to cerebrospinal fluid (ADCmin Node/CSF) (r = -0.364; p = 0.012) were correlated with SUVmax. Cutoff values for DW-MRI parameters were determined using ROC analysis. Six lymph nodes were histopathologically examined. Both methods correctly identified one metastatic and two metastasis negative lymph nodes, while staging one lymph node with granulomatous change as metastasis positive. Two metastasis negative lymph nodes, reported as suspicious on PET/CT, were correctly staged on DW-MRI.Conclusion: Our findings indicate that DW-MRI could be at least as valuable as PET/CT in mediastinal staging of patients with lung cancer.

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Comparative Efficacy of Positron Emission Tomography With Fluorodeoxyglucose in Evaluation of Small (<1 cm), Intermediate (1 to 3 cm), and Large (>3 cm) Lymph Node Lesions

Cited by 192 publications

References 10 publications

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

PET scan Misleads to Diagnosis but Leads to Correct Operative Approach

Comparison of diffusion weighted MRI parameters of mediastinal lymph nodes with PET/CT in lung cancer patients

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