Comparative efficacy of nimesulide and ketoprofen on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study

Abstract

This study aimed to compare the effect of nimesulide and ketoprofen on inflammatory parameters related to the surgical removal of third molars. A split-mouth, prospective, randomized, double-blind study was conducted in patients undergoing removal of four third molars. Eighteen eligible patients were allocated to one of two groups to receive treatment two times a day with either ketoprofen 100 mg or nimesulide 100 mg for a period of 3 days. The rescue medication intake (number) and pain intensity were evaluated at 6, 12, 24, and 48 h, and at 7 days postoperatively. Swelling and maximum mouth opening were evaluated at 24 h, 72 h, and 7 days postoperatively. The peak pain score occurred at 6h after surgery in the nimesulide group and at 12h in the ketoprofen group. There was no statistically significant difference between the groups, although pain relief was observed after 48 h in the nimesulide group and after 7 days in the ketoprofen group. For each group, there was a statically significant difference in pain scores among the studied periods (P<0.0001). None of the patients required rescue medication. There was a statistically significant difference in maximum mouth opening between the preoperative and postoperative periods (P<0.0001). Ketoprofen and nimesulide were effective at controlling pain, swelling, and trismus after the surgical removal of third molars.

Experimentally Induced Pulpal Lesion and Substance P Expression: Effect of Ketoprofen—A Preliminary Study

“…In this preliminary study, considering the limited number of patients, ketoprofen does not seem to interfere significantly in the SP expression in the pulp with induced lesion. Considering the efficacy of this molecule in the modulation of pain and inflammation in third molar surgery previously reported [ 21 ], this result may appear rather disappointing. However, the short duration of the experimentally induced inflammation (15 minutes) may be responsible for the negative result and more studies with larger samples could be necessary to evaluate the effect of this molecule and other NSAIDs also in noninduced experimental pulpal lesions.…”

Continuous preparation of nimesulide nanoparticles by liquid antisolvent precipitation using spinning disc reactor

“…This requires high dosages of these drugs in order to bring out the required therapeutic effect with consequent detrimental effects on the patient's health . Nimesulide (4‐nitro‐2‐phenoxymethanesulfonamide) (NIM) is a comparatively COX‐2 choosy, nonsteroidal anti‐inflammatory drug (NSAID) which acts as an antipyretic, analgesic and anti‐inflammatory agent, and is widely used in treating acute pain due to various diseases such as headache, migraine, back pain and postoperative pain . Nimesulide is reported to have poor solubility in water (0.01 mg mL −1 ), which results in administration of higher doses of the drug in order to maintain drug's plasma concentration at the therapeutic level.…”

Evaluation of low-level laser at auriculotherapy points to reduce postoperative pain in inferior third molar surgery: study protocol for a randomized controlled trial

“…The postoperative period of third molar surgery is usually accompanied by pain, trismus and swelling, and controlling these symptoms is essential for patient comfort. An inflammatory reaction followed by phlogistic symptoms are common and compromise the quality of life of patients during the first 3 days after surgery [1–3], and about 63 % of patients feel intense pain during the first day after surgery, with greater intensity 3–5 h after the end of anesthesia [4]. Among complications after this type of surgery are alveolar osteitis (dry socket) abscess, fever, reactive lymph node pathology and fever, among others already mentioned [5].…”