Comparative Efficacy of Newer Antidepressants in Combination with Pregabalin for Fibromyalgia Syndrome: A Controlled, Randomized Study

Ramzy, Eiad A.

doi:10.1111/papr.12409

Cited by 14 publications

(10 citation statements)

References 28 publications

(38 reference statements)

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“…No urinary dysfunction was observed in a placebo‐controlled study after pregabalin administration 11 . In two other studies the effects of administering gabapentinoids has been compared with those of antidepressants (nortriptyline and duloxetine) demonstrating a lower rate of emptying disorders for gabapentinoids 20,37 …”

Section: Resultsmentioning

confidence: 99%

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Urinary side effects of psychotropic drugs: A systematic review and metanalysis

Trinchieri

Perletti

Magri³

et al. 2021

Neurourology and Urodynamics

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Objective: To evaluate the effects of psychotropic drugs on bladder function. Materials and Methods: A systematic review was carried out by searching PubMed and Embase databases for randomized controlled trials enrolling patients treated with psychotropic drugs with available information on treatment-related urinary disorders.Results: A total of 52 studies was selected. In antidepressant therapy, bladder voiding symptoms, rather than storage symptoms, were more frequently observed.Pooled analysis demonstrated a higher odds ratio (OR) of voiding disorders in comparison with placebo (OR: 3.30; confidence interval [CI]: 1.90-5.72; 7856 participants; p < 0.001). Odds for voiding dysfunction was higher for tricyclic antidepressants and for Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) when compared to Selective Serotonin Reuptake Inhibitors (SSRIs). Treatment with antipsychotics was associated with heterogeneous urinary disorders including emptying and storage disorders. OR for incontinence in patients with dementia taking antipsychotics was higher than placebo (OR: 4.09; CI: 1.71-9.79, p = 0.002) with no difference between different atypical antipsychotics. Rate of voiding disorders was not different between conventional and atypical antipsychotics (OR: 1.64; CI: 0.79-3.39, p = 0.19), although quetiapine showed higher odds to cause voiding dysfunction than other atypical antipsychotics (OR: 2.14; CI: 1.41-3.26; p > 0.001). Conclusions: In patients taking tricyclic antidepressants or SNRIs, bladder voiding disorders, could be the side effects of therapy rather than symptoms of a urological disease. Patients treated with these drugs should be actively monitored for the appearance of urinary symptoms. Antipsychotic treatment is associated with various urinary side effects requiring a tailored approach.

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Section: Resultsmentioning

confidence: 99%

“…11 In two other studies the effects of administering gabapentinoids has been compared with those of antidepressants (nortriptyline and F I G U R E 7 Incontinence after administration of antipsychotics compared to placebo duloxetine) demonstrating a lower rate of emptying disorders for gabapentinoids. 20,37…”

Section: Gabapentinoidsmentioning

confidence: 99%

Urinary side effects of psychotropic drugs: A systematic review and metanalysis

Trinchieri

Perletti

Magri³

et al. 2021

Neurourology and Urodynamics

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“…Moreover, in a randomized controlled study by Ramzy [19], the combined use of pregabalin plus paroxetine (SSRI) for fibromyalgia management in comparison with the combined use of pregabalin plus either amitriptyline (TCA) or venlafaxine was evaluated. Medication termination due to drowsiness, dizziness, blurred vision, abnormal taste, hunger, hallucination, urination problems, and sexual dysfunction was reported mostly in the amitriptyline group.…”

Section: Discussionmentioning

confidence: 99%

“…Incomplete records were excluded from statistical analysis with reporting the cause of not completing the record. [19], taste disturbances were found in 8% in SSRIs and 83% in tricyclic group. Using power 95% and 5% significance level, 8 patients in each group were required.…”

Section: Biasmentioning

confidence: 92%

Gustatory Dysfunction among a Sample of Depressed Egyptian Adults under Antidepressants Therapy: A Retrospective Cohort Study

Mikhail

Elgaaly

Hamid

et al. 2021

International Journal of Dentistry

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It is quite clear that the ability to perceive taste sensations significantly affects food choice, which consequently affects health status in the long term. Gustatory dysfunction is a neglected symptom among the depressed patients and those under antidepressants therapy, although these patients are suspectable to oral problems, due to general self-negligence related to mental disease, fear of dental treatment, and side effects of varied medications utilized in psychiatry. This study is aimed at assessing gustatory thresholds (detection and recognition thresholds) among a sample of 30 depressed Egyptian adults under antidepressants therapy for at least 3 months or psychotherapy with age ranging from 20 to 50 years old, seeking the Psychiatric Clinic at the Faculty of Medicine, Cairo University, Egypt. These patients were distributed into three equal groups (tricyclic antidepressants (TCA), selective serotonin reuptake inhibitors (SSRIs), and psychotherapy) and were assessed for gustatory detection and recognition thresholds using the filter paper disc method through a scoring system. The participants were also divided into normal taste group in which both the detection and recognition scores were 1, while the scores from 2 till 5 were considered as hypogeusia group and the score of 6 was considered as dysgeusia group. The TCA group was statistically significant from the other 2 groups in sweet detection thresholds ( p = 0.043) and sweet recognition thresholds ( p = 0.007). Hypogeusia for sweet was statistically significant ( p = 0.041), where it was more common among TCA (70%) than both SSRIs and the psychotherapy group (20%). Gustatory dysfunction was found to be mostly associated with TCA followed by SSRIs particularly for sweet taste thresholds. More attention has to be given to taste changes among these patients as oral health affects general health by causing considerable pain and by changing what people eat, their speech, and their quality of life and wellbeing. Proper awareness and evaluation of this problem will improve the quality of life for the depressed patients and avoid unnecessary treatment. This trial is registered with ClinicalTrials.gov ID: NCT03599011.

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“…In a single-blind randomized trial, the combined use of pregabalin (75 mg/day) plus paroxetine (25 mg/day), amitriptyline (25 mg/day) or venlafaxine (75 mg/day) resulted in significantly lower somatic symptom and depression scale scores, better life satisfaction, mood, and sleep quality, higher medication tolerability, and less frequent adverse effects in patients with FM [57].…”

Section: Bioamine Neurotransmittersmentioning

confidence: 99%

Potential drug therapies for the treatment of fibromyalgia

Lawson

2016

Expert Opinion on Investigational Drugs

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Modest improvement of health status in patients with FM has been observed with drugs targeting a diverse range of molecular mechanisms. No single drug, however, offered substantial efficacy against all the symptoms characteristic of FM. Identification of new and improved therapies for FM needs to address the heterogeneity of the condition, which suggests existence of patient subgroups, the relationship of central and peripheral aspects of the pathophysiology and a requirement of combination therapy with drugs targeting multiple molecular mechanisms.

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Comparative Efficacy of Newer Antidepressants in Combination with Pregabalin for Fibromyalgia Syndrome: A Controlled, Randomized Study

Abstract: The combined use of pregabalin plus paroxetine offers an effective method with increased tolerability to reduce the somatic and depressive symptoms of fibromyalgia and to enhance the quality of life in affected individuals.

Cited by 14 publications

References 28 publications

Urinary side effects of psychotropic drugs: A systematic review and metanalysis

Urinary side effects of psychotropic drugs: A systematic review and metanalysis

Gustatory Dysfunction among a Sample of Depressed Egyptian Adults under Antidepressants Therapy: A Retrospective Cohort Study

Potential drug therapies for the treatment of fibromyalgia

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