“…A network meta-analysis (NMA) is a statistical method that can be used to compare various therapies by combining direct and indirect evidence across a network of studies [ 18 , 19 ]. The benefits of different inhaled ICS therapies in reducing severe asthma exacerbations have been described in recent years through numerous systematic evaluations that incorporated NMA methodologies [ [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] ]. However, trials evaluating various therapies have adopted different strategies to account for clinical heterogeneity.…”