Comparative Efficacy of Histrelin Acetate and hCG for Inducing Ovulation in Brazilian Northeastern Jennies (Equus africanus asinus)

Oliveira, Sidnei Nunes de; Segabinazzi, Lorenzo G.T.M.; Canuto, Lucas Emanuel Ferreira; Lisboa, Fernando Paixão; Medrado, Felipe Erison; Dell’Aqua, J.A.; Aguiar, Antonio J. A.; Papa, Frederico Ozanam

doi:10.1016/j.jevs.2020.103146

Cited by 2 publications

(5 citation statements)

References 33 publications

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“…7 In another study, the same authors reported that hCG and histrelin acetate had similar efficacy to induce ovulation in jennies with 29 -32 mm follicles, with 90 and 100% of ovulation occurring between 36 -48 hours after treatment, respectively. 9 Similar to other authors description, in the present study, the interval between detection of > 30 mm follicle and ovulation was reduced by treatments (hCG or deslorelin acetate). However, when jennies had ovulation induction treatment with 27 -30 mm follicle, there was no change in this interval compared to the Control-matched cycle.…”

Section: Discussionsupporting

confidence: 92%

“…We evaluated hCG and deslorelin acetate use to induce ovulation in Caribbean jennies in the tropics. Although ovulation-inducing agents (e.g., hCG and GnRH analogs) have been described to induce ovulation in jennies, [6][7][8][9]18 there was no study assessing the efficacy of these hormones to hasten ovulation in jennies in a tropical environment. Recently, some countries in the tropical zone (e.g., Brazil, Ecuador, and Colombia) have reported a decrease in herd number of donkeys, and therefore, there has been an increase in interest to improve the breeding management of this species to prevent threatened extinction.…”

Section: Discussionmentioning

confidence: 99%

“…In the first study of our group, the maximum follicular diameter before ovulation in Caribbean jennies was 34.64 ± 2.91 mm, 20 prompting us to test both intervals (27 -30 and > 30 mm follicle) for ovulation induction. Although the diameter of preovulatory follicles have a large variation based on donkey's breed (30 -45 mm), 6,7,9,18,[21][22][23] in a Brazilian study assessing the efficacy of histrelin acetate to hasten ovulation in Northwest jennies with various follicle diameters, follicles 29 -32 mm had the most satisfactory response. 7 In another study, the same authors reported that hCG and histrelin acetate had similar efficacy to induce ovulation in jennies with 29 -32 mm follicles, with 90 and 100% of ovulation occurring between 36 -48 hours after treatment, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Human chorionic gonadotropin binds to LH receptors in granulosa cells directly to induce ovulation 10 whereas GnRH analogs induce endogenous release of LH by the adenohypophysis. 11,12 In mares, hCG has been reported to have a shorter interval to induce ovulation than GnRH analogs; 13 however, it has not been observed in Brazilian Northwest 9 or Martina Franca 6 jennies in the subtropical and temperate environment, respectively. To the best of the authors' knowledge, there has been no study evaluating ovulation-inducing agents in jennies in tropical regions.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, some studies have reported the efficacy of GnRH analogs (e.g., deslorelin acetate, buserelin, and histrelin acetate) and human chorionic gonadotropin (hCG) to hasten ovulation in jennies. [6][7][8][9] Although GnRH analogs and hCG have similar efficacy to hasten ovulation in jennies, 6,9 these hormones act differently on the ovaries. Human chorionic gonadotropin binds to LH receptors in granulosa cells directly to induce ovulation 10 whereas GnRH analogs induce endogenous release of LH by the adenohypophysis.…”

Section: Introductionmentioning

confidence: 99%

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Ovulation induction in Caribbean jennies in the tropics

French

Segabinazzi

Kent

et al. 2022

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The population of some endangered donkey breeds in tropical regions has declined recently. Therefore, there is an increasing interest to improve the reproductive management of these animals. Ovulation induction agents are often used in equine practice to optimize reproduction techniques. However, limited information exists to support its use in donkeys. Therefore, we compared 2 ovulation-inducing agents (commonly used in equine practice) to hasten ovulation in Caribbean jennies in the tropics. Five cycles of 8 Caribbean jennies were used. Jennies were monitored via transrectal ultrasonography and in 4 estrous cycles they had ovulation induced with either 2,500 IU of hCG or 1.8 mg of deslorelin acetate when a follicle measuring between 27 - 30 mm or > 30 mm in diameter was diagnosed. In the Control-assigned cycle, jennies were not treated with hormones and had spontaneous ovulation. Follicle diameters affected (p < 0.05) the interval to ovulation. When given with a follicle > 30 mm, either treatment reduced (p < 0.05) the interval to ovulation. A higher percentage of jennies ovulated within 48 hours after hCG or deslorelin acetate with > 30 mm follicle (p < 0.05), and with deslorelin acetate with 27 - 30 mm follicle (p < 0.05) than in the Control-assigned cycle. In conclusion, Caribbean jennies in tropics with > 30 mm follicle responded to ovulation induction with hCG or deslorelin acetate, with ovulation occurring within 48 hours.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ovulation induction in Caribbean jennies in the tropics

French

Segabinazzi

Kent

et al. 2022

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Structural and Functional Dynamics of the Ovary and Uterus during the Estrous Cycle in Donkeys in the Eastern Caribbean

Segabinazzi

Gilbert

Ambrosia

et al. 2022

Animals

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Eight non-bred, non-pregnant, regularly cycling Caribbean jennies were examined daily via transrectal ultrasound to define the ovarian and uterine dynamics during four consecutive estrous cycles. Blood samples were collected every other day for progesterone analysis. The mean (±SD) overall inter-ovulatory interval across all donkeys and cycles was 22.93 ± 1.99 days. The maximum follicular diameter was 34.6 ± 2.9 mm. A two-wave pattern was evident in 97% (30/31) of the cycles. The emergence of the future dominant follicle and the largest subordinate follicle of the major primary wave coincided on Day 5.7 ± 3.6 post-ovulation, whereas the secondary wave emerged on Day 19.8 ± 2.9 during estrus of the previous cycle or early diestrus. The secondary wave was often minor (93%, 28/30 cycles). Follicular deviation occurred 8.2 ± 1.4 days before the subsequent ovulation. Luteal volume increased for the first four days after ovulation and reached a maximum volume of 8.5 ± 2.7 mm3 at Day 5.4 ± 0.4, before gradually regressing after Day 15. Serum progesterone concentration increased from Day 1 after ovulation, peaking at 27.0 ± 9.6 ng/mL between 7 and 10 days after ovulation. Progesterone concentration dropped precipitously around Day 15 after ovulation and was below 2 ng/mL around Day 17 ± 2. A day effect (p < 0.0001) was observed for corpus luteum’s volume, progesterone concentration, and uterine tone, but not for endometrial edema (p > 0.05). This study helps to clarify and define normal estrous characteristics of jennies in the Eastern Caribbean.

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Comparative Efficacy of Histrelin Acetate and hCG for Inducing Ovulation in Brazilian Northeastern Jennies (Equus africanus asinus)

Cited by 2 publications

References 33 publications

Ovulation induction in Caribbean jennies in the tropics

Ovulation induction in Caribbean jennies in the tropics

Structural and Functional Dynamics of the Ovary and Uterus during the Estrous Cycle in Donkeys in the Eastern Caribbean

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