1997
DOI: 10.1016/s0035-9203(97)90397-7
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Comparative efficacy of halofantrine, chloroquine and sulfadoxine-pyrimethamine for treatment of acute uncomplicated falciparum malaria in Nigerian children

Abstract: One hundred and ten children aged 6 months to 11 years were randomly treated with halofantrine (HF), sulfadoxine-pyrimethamine (S-P) or chloroquine (CQ) for acute uncomplicated Plasmodium falciparum malaria in an endemic area of south-western Nigeria. The response of infection to treatment in each child was monitored for 14 d. The mean fever clearance times were 1.9 d (n = 36), 1.6 d (n = 27), and 1-7 d (n = 28) for children treated with HF, S-P and CQ, respectively. The parasite clearance times were 3.4 d (n … Show more

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Cited by 57 publications
(34 citation statements)
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“…This progressive decline in the sensitivity of P. falciparum is most marked with chloroquine and sulfadoxine-pyrimethamine, which until recently were first-line antimalarial drugs in Nigeria. Failure rates as high as 50% to 95% have been reported for chloroquine in some parts of the country (Sowunmi & Salako 1992;Falade et al 1997;Federal Ministry of Health 2004). The World Health Organization (2001) has recommended artemisinin-based combination therapy (ACT) for the treatment of malaria in countries experiencing resistance to antimalarial drug monotherapy (World Health Organization 2001).…”
Section: Introductionmentioning
confidence: 99%
“…This progressive decline in the sensitivity of P. falciparum is most marked with chloroquine and sulfadoxine-pyrimethamine, which until recently were first-line antimalarial drugs in Nigeria. Failure rates as high as 50% to 95% have been reported for chloroquine in some parts of the country (Sowunmi & Salako 1992;Falade et al 1997;Federal Ministry of Health 2004). The World Health Organization (2001) has recommended artemisinin-based combination therapy (ACT) for the treatment of malaria in countries experiencing resistance to antimalarial drug monotherapy (World Health Organization 2001).…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] Despite the emergence and spread of resistance, chloroquine and pyrimethamine/sulfadoxine remain the first-and second-line treatments for malaria in most African countries. [3][4][5][6] Malaria control efforts need to be designed for the specific environment in which they will be used, taking into account the local epidemiology. Also, the drug-resistant strains of malaria are constantly changing in time and space.…”
Section: Introductionmentioning
confidence: 99%
“…This concentration, however, may not be sufficient to protect individuals from infection with resistant parasites. In Nigeria, the efficacy of CQ has continuously declined in recent years, such that the cure rate at day 7 of treatment is 40% (5).…”
mentioning
confidence: 99%