Comparative Efficacy of Frontline Tri-Act<sup>®</sup> Spot on (Fipronil/Permethrin) versus Seresto<sup>®</sup> Collar (Imidacloprid/Flumethrin) against Fleas (<i>Ctenocephalides felis</i>) and Ticks (<i>Rhipicephalus sanguineus</i>) on Dogs with Simulation of Bi-Monthly Rain Exposure

Abstract

The objective of the study was to compare the efficacy of one topical insecticide-acaricide (Frontline Tri-Act®) and of one collar (Seresto®) against fleas (Ctenocephalides felis) and ticks (Rhipicephalus sanguineus) on dogs exposed to bi-weekly water showering. Twenty four (24) dogs were enrolled in the study. A first set of 16 dogs were acclimatised to their cages from Day 1 to 7 and a second set of 8 dogs from Day 163 to Day 169. The 24 dogs were randomly allocated to three groups (1 to 3). Dogs assigned to Group 1 were not treated and served as negative controls. Dogs assigned to Group 2 received the Seresto® collar on Day 0 and dogs in Group 3 received Frontline Tri-Act® on Days 170 and 198. The dogs were observed hourly for four hours after treatment administration for possible adverse reactions. Dogs in Groups 1 and 2 underwent water showering on Days 14, 28, 42, 56, 70, 84, 98, 112, 126, 143 and 157

Field trial investigating the efficacy of a long-acting imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®, Elanco) compared to monthly topical fipronil for the chemoprevention of canine tick-borne pathogens in Cambodia

“…Additional factors that may have impacted the efficacy of the Seresto® collars in the IVP group was the local Cambodian climate, that features a distinct wet monsoon season from May to September ( Bairagi et al., 2020 ). Under conditions of regular rain exposure Seresto® collars have been demonstrated to show a significantly reduced efficacy at preventing tick and flea infestation, whilst topical fipronil does not show such a waning of efficacy under the same conditions ( Halos et al., 2014 ; Beugnet et al., 2018 ). Taking this into consideration, the tropical field conditions our trial subjected the Seresto® collars to may have meant they were not working optimally and therefore reduced their TBP-blocking efficacy when compared to topical fipronil.…”

“…Seresto® collars have been shown to prevent flea and tick infestations with high efficacy (90–100%) for up to 8 months, even in regions with high ectoparasite pressure or within canine populations with regular exposure to rain and other environmental factors that might negatively impact on product effectiveness ( Stanneck et al., 2012b , 2012c ; Brianti et al., 2013 ; Dantas-Torres et al., 2013 ; Halos et al., 2014 ; Beugnet et al., 2018 ). Moreover, Seresto® collars have been shown to be efficacious at preventing the transmission of key canine TBP, including E. canis ( Stanneck & Fourie, 2013 ), Babesia canis ( Fourie et al., 2013b ), Borrelia burgdorferi ( sensu lato ) and Anaplasma phagocytophilum ( Krämer et al., 2020 ) with the last two being important zoonotic agents for which canines act as reservoirs.…”