Comparative Efficacy and Tolerance of 1% Bifonazole Cream and Bifonazole Cream Vehicle in Patients with Tinea versicolor

Abstract

Bifonazole 1% cream (Mycospor®¹) was compared to its cream vehicle in the treatment of tinea versicolor, using a once-a-day application for 2 weeks. Patients were evaluated both clinically and mycologically in order to assess the efficacy and tolerance of the medication. 29 patients were evaluated by statistical analysis. Bifonazole cream 1% was shown to be significantly more effective in the treatment of tinea versicolor when used nightly for 2 weeks than was the vehicle cream.

Guidelines for the management of dermatomycosis (2019)

“…220 In these reports, only a few side-effects were observed, such as contact dermatitis, and no serious side-effects were reported. [217][218][219][220] As described, there is evidence showing the efficacy of topical therapy for the treatment of tinea versicolor, and topical azoles are strongly recommended as the first choice.…”

“…217 In addition, the efficacy of topical antifungal agents, such as bifonazole and miconazole, has been reported. 218,219 Allylamines have been shown to be effective compared with placebo in a systematic review that analyzed four RCT including a total of 372 patients (RR, 6.1; 95% CI, 2.2-16.9). 215 In a terbinafine 1% topical solution placebo-controlled RCT, the clinical and mycological cure rates of the topical terbinafine group after 2 weeks of application were both 75% (21/28).…”

“…On the other hand, of the 31 cases in the treatment group who were followed up for 2 years after the end of treatment, 21 patients (68%) reported recurrence 217 . In addition, the efficacy of topical antifungal agents, such as bifonazole and miconazole, has been reported 218,219 …”

“…In these reports, only a few side‐effects were observed, such as contact dermatitis, and no serious side‐effects were reported 217–220 …”

Treatment of pityriasis versicolor with a shampoo containing 1% bifonazole (AgisporR shampoo) in children

“…Several therapeutic modalities are used in the management of pityriasis versicolor including topical application of selenium sulphide shampoo and topical or systemic antifungal agents 1 . Topical application of bifonazole 1% cream or solution for 2 to 3 weeks is known to be effective in patients with pityriasis versicolor 2–5 . In the present study, daily use of Agispor R shampoo, a new antifungal product containing bifonazole 1%, for 3 weeks was found to be effective, safe and obviously friendly to use, in the treatment of mild to severe cases of pityriasis versicolor in children.…”