Comparative Efficacy and Safety of Common Therapies in Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis

Che, Kexin; Lyu, Qianwen; Gertz, MA

doi:10.1007/s00266-020-01639-9

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Although several treatment modalities for scars have been put forth, no satisfactory treatment has been identied and multiple sideeffects such as signicant pain accompany these treatments. 19 Our team has begun to explore the application of MN technology in the treatment of scars since 2012. 13,14 We discovered that drug-free MNs exhibited contact-dependent inhibition on keloids and broblast proliferation in the studies performed.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

et al. 2023

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“…There are currently various treatment options for keloids, and silicone gel with intralesional corticosteroid injections is first recommended. Surgical resection with postoperative radiation or adjuvant pharmacotherapies, radiation therapies, oral medications and laser-based therapies are also used to treat keloids [4][5][6]. In addition to corticosteroids, injectables also include 5-fluorouracil, botulinum toxin, verapamil, and avotermin.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the skin keloid microenvironment

et al. 2023

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Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the keloid microenvironment. The keloid microenvironment is composed of keratinocytes, fibroblasts, myofibroblasts, vascular endothelial cells, immune cells, stem cells and collagen fibers. Recent advances in the study of keloids have led to novel insights into cellular communication among components of the keloid microenvironment as well as potential therapeutic targets for treating keloids. In this review, we summarized the nature of genetic and epigenetic regulation in keloid-derived fibroblasts, epithelial-to-mesenchymal transition of keratinocytes, immune cell infiltration into keloids, the differentiation of keloid-derived stem cells, endothelial-to-mesenchymal transition of vascular endothelial cells, extracellular matrix synthesis and remodeling, and uncontrolled angiogenesis in keloids with the aim of identifying new targets for therapeutic benefit.

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Secondary data mining of GEO database for long non-coding RNA and Competing endogenous RNA network in keloid-prone individuals

Deng

et al. 2020

Aging

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Comparative Efficacy and Safety of Common Therapies in Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis

Cited by 3 publications

References 4 publications

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

Comparison of the efficacy of seven types of microneedles for treating a rabbit hypertrophic scar model

Characterization of the skin keloid microenvironment

Secondary data mining of GEO database for long non-coding RNA and Competing endogenous RNA network in keloid-prone individuals

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