Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide—meta-analysis

Dineva, Stela; Uzunova, Katya; Pavlova, Velichka; Filipova, Elena; Kalinov, Krassimir; Веков, T.

doi:10.1038/s41371-019-0255-2

Cited by 30 publications

(22 citation statements)

References 36 publications

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“…Recent pharmacoepidemiological studies showed a cumulative, dose-dependent association between hydrochlorothiazide (HCTZ), one of the most widely prescribed diuretic, antihypertensive drug, over the world [ 1 ], and increased nonmelanoma skin cancers (NMSCs) risk [ 2 , 3 ]. On these bases, the European Medicine Agency Pharmacovigilance Risk Assessment Committee, recommended to amend the Summary of Product Characteristics for HCTZ containing products with special warnings and precautions [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study

Bigagli

Cinci

D’Ambrosio

et al. 2021

Oxidative Medicine and Cellular Longevity

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Recent studies reported the association between increased risk of nonmelanoma skin cancers (NMSCs) and the use of hydrochlorothiazide (HCTZ), one of the most commonly prescribed diuretic, antihypertensive drug, over the world. Although HCTZ is known to be photosensitizing, the mechanisms involved in its potential prophotocarcinogenic effects remain unclear. Under acute exposure, therapeutically relevant concentrations of HCTZ (70, 140, and 370 ng/mL) amplified UVA-induced double-strand breaks, oxidative DNA, and protein damage in HaCaT human keratinocytes, and this effect was associated to a defective activity of the DNA repair enzyme, OGG1. Oxidative damage to DNA, but not that to proteins, was reversible within few hours. After chronic, combined exposure to HCTZ (70 ng/mL) and UVA (10 J/cm2), for 9 weeks, keratinocytes acquired a dysplastic-like phenotype characterized by a multilayered morphology and alterations in cell size, shape, and contacts. At the ultrastructural level, several atypical and enlarged nuclei and evident nucleoli were also observed. These transformed keratinocytes were apoptosis resistant, exhibited enhanced clonogenicity capacity, increased DNA damage and inflammation, defective DNA repair ability, and increased expression of the oncogene ΔNp63α and intranuclear β-catenin accumulation (a hallmark of Wnt pathway activation), compared to those treated with UVA alone. None of these molecular, morphological, or functional effects were observed in cells treated with HCTZ alone. All these features resemble in part those of preneoplastic lesions and NMSCs and provide evidence of a biological plausibility for the association among exposure to UVA, use of HCTZ, and increased risk of NMSCs. These results are of translational relevance since we used environmentally relevant UVA doses and tested HCTZ at concentrations that reflect the plasma levels of doses used in clinical practice. This study also highlights that drug safety data should be followed by experimental evaluations to clarify the mechanistic aspects of adverse events.

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Section: Introductionmentioning

confidence: 99%

Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study

Bigagli

Cinci

D’Ambrosio

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…The modifiable contributing factors for IHD are hypertension, diabetes mellitus (DM), lipid imbalance, and cigarette smoking [ 5 ]. These can be classified under metabolic syndrome, which activates plaque formation, promotes thrombosis and inflammation, and increases the risk for cardiovascular disease development [ 6 ]. A range of debilitating conditions such as collagen deposition and elastin reduction regularly exist in older people, resulting in a poor prognosis of IHD with disabilities and impairment in quality of life, worsening their condition [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

miRNA in Ischemic Heart Disease and Its Potential as Biomarkers: A Comprehensive Review

Kong

Lai

Lim

et al. 2022

IJMS

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Ischemic heart disease (IHD) constitutes the leading global cause of mortality and morbidity. Although significant progress has been achieved in the diagnosis, treatment, and prognosis of IHD, more robust diagnostic biomarkers and therapeutic interventions are still needed to circumvent the increasing incidence of IHD. MicroRNAs (miRNAs) are critical regulators of cardiovascular function and are involved in various facets of cardiovascular biology. While the knowledge of the role of miRNAs in IHD as diagnostic biomarkers has improved, research emphasis on how miRNAs can be effectively used for diagnosis and prognosis of IHD is crucial. This review provides an overview of the biology, therapeutic and diagnostic potential, as well as the caveats of using miRNAs in IHD based on existing research.

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“…Chlortalidone is a compound that is often used as a diuretic for diuretic therapy. This compound has been shown to have a therapeutic diuretic effect as an antihypertensive [2]. Chlortalidone contains not less than 98.00% and not more than 102.0% C 14 H 11 C 1 N 2 O 4 S, calculated based on the dried substance.…”

Section: Introductionmentioning

confidence: 99%

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

Fitrizal¹,

Misfadhila²,

Rivai³

2021

IJPSM

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Chlortalidone is a compound that is often used in the pharmaceutical world as an oral drug to treat hypertension. This review article discusses the summary of methods for determining the concentration of chlorthalidone in pharmaceutical preparations and biological matrices. We took the data collected in this review article was taken through trusted sites such as Google Scholar with the search keywords "chlorthalidone determination," "pharmaceutical preparations," and "biological matrices," with a period of the last twenty years (2001-2021). This review article aims to provide an overview of the assay used to determine the concentration of chlorthalidone either in the form of a single substance or pharmaceutical dosage forms. Overall, the determination of chlorthalidone levels has been carried out using various analytical methods. Including spectrophotometry, high-performance liquid chromatography (HPLC), chemometrics and thin-layer chromatography (TLC) - densitometric, capillary zone electrophoresis (CZE) methods, spectrofluorimetric methods, liquid chromatography-mass spectrometry-mass spectrometry (LC-MS-MS) methods, ultrafast liquid chromatography (UFLC), supercritical fluid chromatography method and high-performance thin-layer chromatography (HPTLC)-densitometric method. Analysis with the HPLC technique is widely used in research because it can detect samples with the lowest concentrations up to the nanogram level.

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Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide—meta-analysis

Cited by 30 publications

References 36 publications

Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study

Hydrochlorothiazide Use and Risk of Nonmelanoma Skin Cancers: A Biological Plausibility Study

miRNA in Ischemic Heart Disease and Its Potential as Biomarkers: A Comprehensive Review

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

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