Comparative Efficacies of Antimigraine Drugs Using Nitroglycerin Induced Migraine Rats Model

Abstract

Aim: The migraine pathology is still not explained effectively. There is a common relationship between anxiety, depression, and migraine. So the aim of the study to illustrate effectively the behavioural and biomarker changes in the migraine condition.
 Methods: Nitroglycerin (NTG) induced migraine rats model was used the present study. Twenty-five male Wistar rats were randomly divided into five groups. Ergotamine, sumatriptan, and BIBN4096 were used as antimigraine drugs. The behavioural activity was measured by scratching head, body shaking, and social interaction task. ELISA detected biomarkers like interleukin 6 (IL-6), Substance P (SP) and 5-hydroxytryptamine (5-HT) in various rats brain regions such as cortex, brain stem, trigeminal ganglion.
 Results: A significant reduction in hyperalgesic response and behavioral changes like scratching head, body shaking and social interaction task. Biomarkers like 5-HT, SP and IL-6 were significantly reduced in the various brain regions such as prefrontal cortex, brain stem and trigeminal ganglia of the rats in the BIBN4096 treated groups.
 Conclusion: The present study showed a good antimigraine efficacy with a calcitonin gene-related peptide (CGRP) antagonistic agent BIBN4096 than ergotamine and sumatriptan but still lack of behavioural pattern, need to explore nonpharmacological intervention along with the drug treatment.

Preventive and Therapeutic Effects of Low-Intensity Ultrasound Stimulation on Migraine in Rats

“…Migraine is a vascular and nerve dysfunction disease caused by the interaction of vascular and neural mechanisms [64], [65]. Nitroglycerin can cause migraine in humans and animals [18], [30], [66], [67]. In a study with human subjects, researchers tested six healthy adults with an average age of 27.5 years (range 22-38 years).…”

“…During the nitroglycerin infusion, five out of six subjects experienced headache [30]. In an animal experiment, 10 mg/kg of nitroglycerin was intraperitoneally injected in Wistar rats, which resulted in a statistically detectable increase in head scratching time compared to controls [67]. In addition, nitroglycerin was injected intraperitoneally at a dose of 10 mg/kg to Sprague-Dawley rats.…”