Comparative effects of xenon and nitrous oxide on diaphragmatic contractility in dogs

Abstract

When used at clinical concentration, xenon or N2O does not affect contractility and electrical activity of the diaphragm in dogs.

Autonomic cardiac control with xenon anaesthesia in patients at cardiovascular risk

“…On the other hand, experimental data obtained at the cellular level have shown no effect of xenon on ion channels and contractility in cardiac 3 18 19 and skeletal muscle cells. 20 To date, there is no report on smooth muscle cell effects.…”

Effects of diazepam on diaphragmatic functionand recovery in pentobarbital-anesthetized dogs: An open-label, dose-finding, pharmacologic study

“…When used at clinical concentrations, nitrous oxide has not been found to affect diaphragmatic contractility. 2 In contrast, enflurane, 3 halothane, 3,4 isoflurane, 5 and sevoflurane 6 have been shown to impair the contractile properties of the diaphragm. Like these volatile anesthetics, propofol, widely used for anesthesia and sedation in patients undergoing diagnostic and therapeutic surgical procedures, has been found to decrease diaphragmatic contractility.…”

Clinical study of transdiaphragmatic pressure during general anaesthesia in the dog

“…So, Fujii was dismissed from the hospital. Yoshitaka Fujii was the first who investigated the effect of different drugs like olprinone, diltiazem, inhaled colforsin, milrinone, propofol, midazolam, xenon, nitrous oxide, amrinone, flumazenil on diaphra-gmatic contractility in dogs (Fujii et al 1993;Fujii et al 1995;Fujii et al 1998;Fujii et al 1999a;Fujii et al 1999b;Fujii & Toyooka 2000;Fujii et al 2001a;Fujii et al 2001b;Fujii & Toyooka 2001;Fujii et al 2002;Hoshi et al 2002;Fujii 2003;Fujii et al 2003b;Fujii et al 2003c;Fujii 2004;Fujii et al 2004b). All these papers were very similar concerning the introduction, the materials & methods, the results and the discussion sections.…”