2013
DOI: 10.1016/j.plefa.2013.03.006
|View full text |Cite
|
Sign up to set email alerts
|

Comparative effects of well-balanced diets enriched in α-linolenic or linoleic acids on LC-PUFA metabolism in rat tissues

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
43
0
1

Year Published

2013
2013
2018
2018

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 43 publications
(45 citation statements)
references
References 34 publications
1
43
0
1
Order By: Relevance
“…Interestingly, it has been proposed that such high ratios might represent a significant risk factor in some life-threatening diseases (Simopoulos 2008), including the loss of bone mass density (Jarvinen et al 2012). Even more, recent animal studies have shown that diets with both omega-6 and omega-3 fatty acids may alter the tissue lipidic composition, with a potentially healthier production of inflammatory cytokines when such ratio approaches the value of one (Blanchard et al 2013;Duan et al 2013). Nevertheless, the significance of these findings in the development of some diseases remains to be further studied and validated in well-qualified in vitro/ in vivo experimental models, as well as in epidemiological and intervention studies.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, it has been proposed that such high ratios might represent a significant risk factor in some life-threatening diseases (Simopoulos 2008), including the loss of bone mass density (Jarvinen et al 2012). Even more, recent animal studies have shown that diets with both omega-6 and omega-3 fatty acids may alter the tissue lipidic composition, with a potentially healthier production of inflammatory cytokines when such ratio approaches the value of one (Blanchard et al 2013;Duan et al 2013). Nevertheless, the significance of these findings in the development of some diseases remains to be further studied and validated in well-qualified in vitro/ in vivo experimental models, as well as in epidemiological and intervention studies.…”
Section: Discussionmentioning
confidence: 99%
“…The liver was fractioned in a phosphate buffer containing 0.25 M sucrose to recover the post-mitochondrial supernatant as previously described [18]. Enzymatic activities were assayed in duplicates with different substrates: [1-14 C]20:3n-6 for Δ5-desaturase and [1-14 C]18:1n-9, [1-14 C]18:2n-6, and [1-14 C]18:3n-3 for Δ6-desaturase (60 µmol/L, 10 mCi/mmol).…”
Section: δ5-and δ6-desaturase Activity Assaysmentioning
confidence: 99%
“…Toutefois, les études s'accordent à dire que l'ALA serait un excellent substrat pour la b-oxydation et qu'une majeure partie serait b-oxydée (15 à 33 %) (Burdge et Wootton, 2002 ;Burdge, 2004 ;Arterburn et al, 2006). Seule une faible proportion serait convertie en EPA (8 à 21 %) et en DHA (0,05 à 9 %) (Burdge et Wootton, 2002 ;Burdge, 2004 ;Harnack et al, 2009 ;Blanchard et al, 2013).…”
Section: Introductionunclassified