Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis

Li, Yanfei; Marín, Fernando; Stepan, Jan J.; Ish‐Shalom, Sophia; Möricke, R; Hawkins, Federico; Kapetanos, G.; Pena, M. Pena; Kekow, Jörn; Martínez, Guillermo; Malouf, Jorge; Zeng, Qing; Wan, Xiaohai; Recker, Robert R.

doi:10.1016/j.bone.2011.01.012

Cited by 26 publications

(12 citation statements)

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“…The increase in periosteal circumference is consistent with prior human and animal studies of PTH therapy. 21, 22 The increase in endosteal circumference is consistent with a study of bone biopsies in adult dialysis patients, demonstrating that hyperparathyroidism was associated with endocortical resorption. 23 …”

Section: Discussionsupporting

confidence: 80%

Changes in bone structure and the muscle–bone unit in children with chronic kidney disease

Tsampalieros

Kalkwarf

Wetzsteon

et al. 2013

Kidney International

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The impact of pediatric chronic kidney disease (CKD) on acquisition of volumetric bone mineral density (BMD) and cortical dimensions is lacking. To address this issue we obtained tibia quantitative computed tomography scans from 103 patients age 5-21 years with CKD (26 on dialysis) at baseline and 12 months later. Gender, ethnicity, tibia length and/or age-specific Z-scores were generated for trabecular and cortical BMD, cortical area, periosteal and endosteal circumference, and muscle area based on over 700 reference subjects. Muscle area, cortical area, and periosteal and endosteal Z-scores were significantly lower at baseline compared to the reference cohort. Cortical BMD, cortical area and periosteal Z-scores all exhibited a significant further decrease over 12 months. Higher parathyroid hormone levels were associated with significantly greater increases in trabecular BMD and decreases in cortical BMD in younger patients (significant interaction terms for trabecular BMD and cortical BMD). The estimated GFR was not associated with changes in BMD Z-scores independent of parathyroid hormone. Changes in muscle and cortical area were significantly and positively associated in control subjects but not in CKD patients. Thus, children and adolescents with CKD have progressive cortical bone deficits related to secondary hyperparathyroidism and potential impairment of the functional muscle-bone unit. Interventions are needed to enhance bone accrual in childhood-onset CKD.

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Section: Discussionsupporting

confidence: 80%

Changes in bone structure and the muscle–bone unit in children with chronic kidney disease

Tsampalieros

Kalkwarf

Wetzsteon

et al. 2013

Kidney International

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“…However, it is not known if the increase in DBM with bisphosphonates is associated with improved cortical bone strength. On the other hand, PTH increases endocortical bone formation [56–61] and cortical porosity [57, 58, 62, 63]; increases cortical area and thickness [19, 56, 58, 61, 64–67]; decreases cortical bone strength [62]; increases the rate of Haversian remodeling [58, 60, 62, 65]; and stimulates periosteal bone formation [55, 58, 59]. The opposite effects of bisphosphonates and PTH on cortical bone endpoints such as cortical porosity and endocortical bone formation rate suggest that combining them in strategic sequences could produce better therapeutic results than can be achieved by any monotherapy.…”

Section: Introductionmentioning

confidence: 99%

Effect of sequential treatments with alendronate, parathyroid hormone (1–34) and raloxifene on cortical bone mass and strength in ovariectomized rats

Amugongo

Yao

Jia

et al. 2014

Bone

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Anti-resorptive and anabolic agents are often prescribed for the treatment of osteoporosis continuously or sequentially for many years. However their impact on cortical bone quality and bone strength is not clear. Methods Six-month old female rats were either sham operated or ovariectomized (OVX). OVX rats were left untreated for two months and then were treated with vehicle (Veh), hPTH (1-34) (PTH), alendronate (Aln), or raloxifene (Ral) sequentially for three month intervals, for a total of three periods. Mid-tibial cortical bone architecture, mass, mineralization, and strength were measured on necropsy samples obtained after each period. Bone indentation properties were measured on proximal femur necropsy samples. Results Eight or more months of estrogen deficiency in rats resulted in decreased cortical bone area and thickness. Treatment with PTH for 3 months caused the deposition of endocortical lamellar bone that increased cortical bone area, thickness, and strength. These improvements were lost when PTH was withdrawn without followup treatment, but were maintained for the maximum times tested, six months with Ral and three months with Aln. Pre-treatment with anti-resorptives was also somewhat successful in ultimately preserving the additional endocortical lamellar bone formed under PTH treatment. These treatments did not affect bone indentation properties. Summary Sequential therapy that involved both PTH and anti-resorptive agents was required to achieve lasting improvements in cortical area, thickness, and strength in OVX rats. Anti-resorptive therapy, either prior to or following PTH, was required to preserve gains attributable to an anabolic agent.

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“…These drugs act by suppressing bone resorption but also decrease bone formation (4). Teriparatide (TPTD-hPTH 1-34) is the only currentlyavailable anabolic agent and acts by a mechanism that involves stimulating new bone formation (along with resorption), and reconstituting internal bone microarchitecture (5)(6)(7). The effects of teriparatide on bone mineral density (BMD) are superior to antiresorptive agents at the spine, but its effects at the hip are more modest, and often delayed until the second year of a 2-year course of therapy (8,9).…”

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confidence: 99%

Effects of Abaloparatide, a Human Parathyroid Hormone-Related Peptide Analog, on Bone Mineral Density in Postmenopausal Women with Osteoporosis

Leder

O’Dea

Zanchetta

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

208

188

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Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis

Cited by 26 publications

References 50 publications

Changes in bone structure and the muscle–bone unit in children with chronic kidney disease

Changes in bone structure and the muscle–bone unit in children with chronic kidney disease

Effect of sequential treatments with alendronate, parathyroid hormone (1–34) and raloxifene on cortical bone mass and strength in ovariectomized rats

Effects of Abaloparatide, a Human Parathyroid Hormone-Related Peptide Analog, on Bone Mineral Density in Postmenopausal Women with Osteoporosis

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