Comparative Effects of Somatotrophic Hormone and Pancreatic Hyperglycemic Factor on Body Weight and Chondrogenesis in the Hypophysectomized Rat

Changes in the Islets of Langerhans Associated With Age and Hibernation

“…On the other hand, it is relevant to recall the hypothesis that growth hormone only indirectly controls growth [Salter and Best, 1953;Elrick, 1953;Lawrence, Salter and Best, 1954], and that its principal and direct action is to stimulate the pancreatic islets, especially the alpha cells. This hypothesis, although not supported by the experiments of Mitchell, Rice and Girerd [1954] on young hypophysectomized rats injected with glucagon, seems to be clearly confirmed by Cavallero's [1954Cavallero's [ , 1956 experiments with glucagon on the chick embryo and on pituitary dwarf mice. If this is the case, then the behaviour of the alpha/beta cell ratio observed here would seem to accord with the expected bodily requirements at different stages of body growth.…”