Comparative effects of somatostatin-28 and somatostatin-14 on basal growth hormone release and pancreatic function in immature ducks (Anas platyrhynchos)

Strosser, M.T.; Harvey, S.; Foltzer, C.; Mialhe, P

doi:10.1016/0016-6480(84)90040-6

Cited by 25 publications

(10 citation statements)

References 31 publications

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“…Although prolonged i.v. infusion of SRIF has been shown to lower basal GH concen¬ trations in ducklings (Strosser et al 1984(Strosser et al , 1985, other studies also report that bolus injections of SRIF fail to lower circulating GH levels in chicks, even at doses of 100 pg/kg (Harvey, Scanes, Bolton & Chadwick, 1978;Taylor, Ball, Barreto et al 1984).…”

Section: Discussionmentioning

confidence: 94%

“…These peptides are likely to be involved in the control of growth hormone (GH) release from the avian pituitary gland, since synthetic SRIF inhibits basal and stimulated GH release both in vitro and in vivo (Harvey, 1983;Leung & Taylor, 1983;Strosser, Harvey, Foltzer & Mialhe, 1984. The possibility that immunoneutralization of endogenous SRIF might increase basal and stimulated GH secretion has therefore been examined in the present study.…”

Section: Introductionmentioning

confidence: 95%

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Somatostatin tonically inhibits growth hormone secretion in domestic fowl

Harvey¹,

Lam²,

Hall³

1986

Journal of Endocrinology

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Passive immunization of immature chickens with sheep somatostatin (SRIF) antiserum promptly increased the basal plasma GH concentration and augmented TRH-induced GH secretion. Although exogenous SRIF had no inhibitory effect on the basal GH concentration in untreated birds or birds pretreated with non-immune sheep serum, it suppressed the stimulatory effect of SRIF immunoneutralization on GH secretion. These results suggest that SRIF is physiologically involved in the control of GH secretion in birds, in which it appears to inhibit GH release tonically.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 95%

Somatostatin tonically inhibits growth hormone secretion in domestic fowl

Harvey¹,

Lam²,

Hall³

1986

Journal of Endocrinology

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“…The affinity of these binding sites for SRIF-28 was greater than that for SRIF-14, as in mammalian studies (Srikant & Patel, 1982;Srikant & Heisler, 1985) in which SRIF-28 is more potent than SRIF-14 in inhibiting GH secretion (Tannenbaum, Ling & Brazeau, 1982). The influence of SRIF-28 on GH secretion in domestic fowl has not been determined, although it is at least, if not more, active than SRIF-14 in inhibiting GH release in ducks (Strosser et al 1984). The greater affinity of these binding sites for SRIF-28 is not, however, due to its N-terminal se¬ quence, since SRIF-28(1-12) was unable to displace [^I-Tyr^-SRIF binding.…”

Section: Discussionmentioning

confidence: 90%

“…Exogenous SRIF also inhibits basal plasma GH concentrations in chickens and ducks (Strosser, Harvey, Foltzer & Mialhe, 1984;Foltzer, Strosser, Harvey & Mialhe, 1985;Harvey & Scanes, 1987;Scanes & Harvey, 1989) and blocks the in-vivo (Harvey & Scanes, 1987;Scanes & Harvey, 1989) and in-vitro (Perez, Malamed & Scanes, 1987;Foltzer-Jourdainne, Har¬ vey & Mialhe, 1988) GH response to GH-releasing factor or thyrotrophin-releasing hormone (TRH). These effects are likely to be mediated by specific SRIF receptors on pituitary somatotrophs, as ob¬ served on tumorous somatotrophs (Schonbrunn 8c Tashjian, 1980; Moyse, Le Dafniet, Epelbaum et al 1985) and healthy pituitary tissue (Leitner, Rifkin, Maman & Sussman, 1979;Srikant & Patel, 1982; Lewis & Williams, 1987) in mammals.…”

Section: Introductionmentioning

confidence: 96%

Somatostatin binding to chicken adenohypophysial membranes

Harvey

Attardo²,

Baidwan³

1990

Journal of Molecular Endocrinology

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[125I-Tyr1]-Somatostatin (SRIF)-binding sites were demonstrated on crude plasma membrane preparations from chicken pituitary glands. These binding sites were saturable and of high affinity (dissociation constant less than 1.0 nM) and low capacity (maximal binding capacity less than 200 fmol/mg protein) and were specific for SRIF moieties. The number and affinity of these binding sites in the caudal lobe of the pituitary, in which somatotrophs predominate, were similar to those in the cephalic lobe, in which lactotrophs and thyrotrophs are confined. Gonadotrophs are present in the caudal lobe, but whereas exogenous SRIF inhibited secretagogue-induced GH release from incubated pituitary glands, it had no effect on basal or secretagogue-induced LH release. The half-maximal binding of SRIF to the caudal lobe membranes (3 nM) was similar to that required for half-maximal suppression of TRH-induced GH release, suggesting a role for these binding sites in the regulation of GH secretion in birds.

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“…Thus, although the TRH content of the chicken hypothalamus is low ( < 100 pg; Jackson & Reichlin, 1974), it may reflect a rapid turnover of TRH within the hypothalamus and be sufficient to accentuate GRF-induced GH release. The prompt decline in the basal GH concentration after TRH im¬ munoneutralization may, alternatively, indicate that GH secretion is under tonic somatostatin inhibition (Harvey, 1983a;Strosser, Harvey, Foltzer & Mialhe, 1984) and that episodic bursts of GH release (Scanes, Lauterio & Buonomo, 1983;Buonomo, Lauterio & Scanes, 1984) result from phasic stimulation by TRH and/or GRF.…”

Section: Discussionmentioning

confidence: 96%

Physiological control of growth hormone secretion by thyrotrophin-releasing hormone in the domestic fowl

Klandorf¹,

Harvey²,

Fraser³

1985

Journal of Endocrinology

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Immature cockerels (4- to 5-weeks old) were passively immunized, with antiserum raised in sheep, against thyrotrophin-releasing hormone (TRH). The administration of TRH antiserum (anti-TRH) at doses of 0.5, 1.0 or 2.0 ml/kg lowered, within 1 h, the basal concentration of plasma GH for at least 24 h. The administration of normal sheep serum had no significant effect on the GH concentration in control birds. Although the GH response to TRH (1.0 or 10.0 micrograms/kg) was not impaired in birds treated 1 h previously with anti-TRH, prior incubation (at 39 degrees C for 1 h) of TRH (20 micrograms/ml) with an equal volume of anti-TRH completely suppressed the stimulatory effect of TRH (10 micrograms/kg) on GH secretion in vivo. These results suggest that TRH is physiologically involved in the hypothalamic control of GH secretion in the domestic fowl.

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Comparative effects of somatostatin-28 and somatostatin-14 on basal growth hormone release and pancreatic function in immature ducks (Anas platyrhynchos)

Cited by 25 publications

References 31 publications

Somatostatin tonically inhibits growth hormone secretion in domestic fowl

Somatostatin tonically inhibits growth hormone secretion in domestic fowl

Somatostatin binding to chicken adenohypophysial membranes

Physiological control of growth hormone secretion by thyrotrophin-releasing hormone in the domestic fowl

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