Comparative effects of polyunsaturated- to saturated fatty acid ratio versus polyunsaturated- and monounsaturated fatty acids to saturated fatty acid ratio on lipid metabolism in rats

Chang, Nai Wen; Huang, Po Chao

doi:10.1016/s0021-9150(98)00236-6

Cited by 34 publications

(21 citation statements)

References 29 publications

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“…[11][12][13][14] These studies commonly discussed P/S ratios of o3.0. 10,[12][13][14] Our previous finding showed that oil with a high P/S ratio was important in lowering body fat accumulation, and high MUFA oil with a high P/S ratio (HMHR; consisting of 60% MUFA of the total fatty acids with high P/S ratio of 5) may prevent high-fat diet-induced increases in body weight and body fat. 15 Compared with HMHR oil, olive oil consists of high MUFA but with a lower P/S ratio; this difference may be one of the reasons preventing fat deposition in obese animals.…”

Section: Introductionmentioning

confidence: 99%

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Liou

et al. 2010

Int J Obes

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Objective: The aim of this study was to assess the relationship between high monounsaturated fatty acids (MUFAs) with different levels of polyunsaturated-to-saturated fatty acid (P/S) ratios and body fat loss in diet-induced obesity (DIO) models. Design: Male Golden Syrian hamsters were randomly assigned to the control group (n ¼ 12) and obesity group (n ¼ 24) for 4 weeks of the high-fat DIO period; afterward, six hamsters from each group were killed. The remaining control hamsters were still fed a low-fat diet. For an additional 8 weeks, the remaining obesity hamsters were switched to a low-fat diet and subdivided into three subgroups (n ¼ 6/group): the obesity-control (ObC) group, high MUFA with high P/S ratio oil (HMHR) group and olive oil (OO) group. Serum insulin and leptin concentrations were measured, and hepatic fatty acid metabolic enzymes and adipose differentiation markers were determined using enzyme activities analysis, western blot and semiquantification reverse-transcription PCR. Results: No difference was observed in the mean energy intake through all study periods. After the DIO period, the obesity group increased in weight gain and epididymal fat weight compared with the control group. DIO hamsters in the HMLR group had significant reductions in white adipose tissue deposition and plasma leptin levels, suppression in adipose peroxisome proliferator-activated receptor-g (PPARg) and lipoprotein lipase (LPL) mRNA expressions and increases in hepatic acyl-CoA oxidase and carnitine palmitoyltransferase-I activities and mRNA levels compared with those in the ObC group. The HMHR group had upregulated phosphorylation of hormone-sensitive lipase (HSL) relative to total HSL protein levels compared with the OO group. However, the OO group had significantly elevated hepatic de novo lipogenesis compared with the HMHR group. Conclusions: HMHR seemed to be beneficial in depleting white adipose tissue accumulation by decreasing adipose PPARg and LPL mRNA expressions and mediating phosphorylation of HSL, and by improving hepatic lipolytic enzyme activities and mRNA expressions involved in b-oxidation in DIO hamsters.

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Section: Introductionmentioning

confidence: 99%

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Liou

et al. 2010

Int J Obes

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“…Have focused on replacing saturated fatty acids by poly unsaturated on diet control which result in decreasing the total cholesterol, triglycerides , low density lipoproteins and increasing high density lipoproteins however this finding goes hand in hand with numerous intervention studies have shown that substitution of dietary saturated fatty acids by poly unsaturated fatty acids in diet has hypocholesterlmic effects, decrease the levels of total cholesterol , low density lipoproteins and increase the high density lipoproteins. 31 Based on the result of the current study, the fourth group which combined the beneficial effect of both diet and exercise showed a significant decrease decreasing weight. Body mass index and altering the lipid profile (decreasing the total cholesterol, triglycerides, low density lipoproteins and increasing high density lipoproteins) when compared to control group or even to each treatment modality alone, which is quit logical.…”

Section: Discussionmentioning

confidence: 70%

Effect of diet control and exercise on the lipid profile of obese men

Alzahrani

2014

Int J Res Med Sci

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“…A higher ratio in milk of total percent PUFAs to total percent SAFAs for SSL pups with foraging mothers may mean less fat deposition when compared with SSL pups with perinatal mothers, as has been shown for infant Syrian hamsters (Mesocricetus auratus, Liao et al 1982). Differing plasma and liver cholesterol levels have been found in rats when fed varying ratios of PUFAs to SAFAs (Chang & Huang 1999), and therefore different ratios may indicate differences in tissue cholesterol levels, including steroid hormones, between pups of perinatal and foraging SSLs.…”

Section: Differences In Fatty Acids Important For Pups Between Maternmentioning

confidence: 88%

Milk fatty acid composition of perinatal and foraging Steller sea lions (Eumetopiasjubatus): examination from pup stomachs

Miller

2018

Can. J. Zool.

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To investigate the milk fatty acid composition of female Steller sea lions (Eumetopias jubatus (Schreber, 1776)) between and within maternal states (i.e., perinatal or foraging), milk samples were collected in 2010 and 2011 via gastric intubation from Steller sea lion pups on a small rookery in the central Gulf of Alaska. Maternal states of lactating females were determined upon reuniting with their sampled pups via remotely operated video cameras on the rookery. Milk fatty acid composition between Steller sea lion maternal states was significantly different, and thus can be utilized to distinguish between perinatal and foraging Steller sea lions of the same geographic region in the absence of direct observation. However, milk fatty acid composition remained relatively constant within perinatal Steller sea lions, suggesting steady mobilization of fatty acids from blubber to milk, and within foraging Steller sea lions, implying females forage on similar prey species within several days after their perinatal period. Differences in milk fatty acid composition between maternal states, including differences in the relative percentages of polyunsaturated fatty acids, may have important implications for growth and development of offspring.

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Comparative effects of polyunsaturated- to saturated fatty acid ratio versus polyunsaturated- and monounsaturated fatty acids to saturated fatty acid ratio on lipid metabolism in rats

Cited by 34 publications

References 29 publications

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARγ related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster

Effect of diet control and exercise on the lipid profile of obese men

Milk fatty acid composition of perinatal and foraging Steller sea lions (Eumetopiasjubatus): examination from pup stomachs

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