Comparative effects of palm vitamin E and α‐tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats

Mazlan, Mohd Zulfakar; Nizrana, M. Y.; Fairuz, A. H.; NoorAini, A. H.; Azian, A. L.; Gapor, M. T.; Ngah, Wan Zurinah Wan

doi:10.1007/s11745-005-1418-9

Cited by 61 publications

(44 citation statements)

References 35 publications

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“…Glutathione plays a role in antioxidant defense, decreasing in the presence of oxidants and delaying wound healing (26). Studies on patients with diabetes have shown a decrease in erythrocyte GSH levels and increased erythrocyte lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Gozen¹,

Demirel²,

Akan³

et al. 2018

Eur J Ther

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Objective: The present study investigated the protective effects of a pulsed electromagnetic field (PEMF) in a rat model of diabetes by analyzing oxidative/nitrosative stress parameters. Methods: Rats were randomly divided into four groups of eight each: a control group, a sham PEMF group, a diabetes group, and a diabetes+PEMF group. Diabetes was induced in the sham PEMF, diabetes, and diabetes+PEMF groups by treatment with 50 mg/ kg streptozotocin (STZ). Rats in the sham PEMF group were treated identically, without running the instrument. Following the development of diabetes, rats in the diabetes+PEMF group were treated with PEMF for 60 min/day for 4 weeks. Results: Levels of oxidants, such as malondialdehyde (MDA), nitric oxide (NO), and myeloperoxidase (MPO), and antioxidants, such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), were measured in blood and liver tissue samples. MPO, MDA, and NO levels were significantly higher, and SOD levels significantly lower, in the sham PEMF and diabetes groups than in the control group (p<0.05 each), whereas the levels of all these four (i.e.: MPO, MDA, NO, and SOD) in the diabetes+PEMF group were close to those in the control group. GSH levels were significantly lower in the sham PEMF, diabetes, and diabetes+PEMF groups than in the control group (p<0.05 each), whereas CAT levels were similar in all the four groups. Conclusion: Results indicate that PEMF affects MDA, NO, MPO, SOD, and GSH levels and regulates diabetes-associated damage by reducing oxidative stress and increasing the levels of antioxidants. PEMF may be a non-invasive treatment option for diabetes and associated complications.

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Section: Discussionmentioning

confidence: 99%

Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Gozen¹,

Demirel²,

Akan³

et al. 2018

Eur J Ther

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“…New evidences from the studies on diabetic mouse models point to an involvement of oxidative stress in diabetic wound healing and significantly improved wound healing by topical vitamin E. 54,55 Another finding showed vitamin E or α-tocopherol supplementation reduced the levels of lipid peroxides in the wound tissue of diabetic rats, and the wound healing process was enhanced, in particular in the Vitamin E treated animals. 56 Tsoureli-Nikita et al 57 performed a clinical single, blind, placebo controlled study in which 96 atopic dermatitis patients were treated with either placebo or oral vitamin E (400 IE/day) for 8 months.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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ÖZAmaç: Bu çalışma, sıçanlarda oluşturulan deneysel yara modelinde Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun, enzimatik antioksidanlar üzerindeki etkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntemler: Genel anestezi altına alınan hayvanlarda, aseptik koşullarda, insizyon yapmak suretiyle kare şeklinde yaralar (2x2 cm) oluşturulmuştur. Daha sonra, hayvanlar rasgele dört gruba ayrılmıştır (I-tedavi edilmemiş kontrol grubu, II-haricen uygulanan baz jel grubu, IIIharicen %5 jel uygulanan grup, IV-haricen %10 jel uygulanan grup). Bulgular: Sonuçlar, Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun haricen uygulanmasının, kontrol ve baz jel gruplarına kıyasla, bütünlüğü bozulmamış stratum bazalisi, olgun granülasyon dokusunu, kıl folikülleri ve ter bezleri ile reepitelizasyonu arttırdığını göstermektedir. Yara oluşumundan 21 gün sonra, %10 yağlı jel ile tedavi edilen hayvanların dokularındaki gerilme kuvveti, kopma gerilimi ve bükülme direnci, kontrol ve baz jel grubu ile karşılaştırıldığında önemli ölçüde artmıştır. Aynı evredeki kontrol ve baz jel ile muamele edilen gruplara kıyasla, kollajen liflerin daha organize bir düzenlenme ve dokunun daha düzgün bir iyileşme gösterdiği belirlenmiştir. Sonuç: Pistacia atlantica yağ jelinin haricen uygulanmasının, sıçanlarda oluşturulan deneysel yaralar üzerinde morfolojik, biyokimyasal ve biyomekanik yönden düzeltici rol oynadığı ortaya koyulmuştur. Anahtar kelimeler: Pistacia atlantica, yara iyileşmesi, histopatoloji, biomekanik, deri Objectives: This study has been undertaken to investigate the antioxidant activity of the gel formulation from Pistacia atlantica oil extraction on enzymatic antioxidants in experimental wound created in rats. Materials and Methods: Under anesthesia, a square-shaped skin defect (2x2 cm) was created aseptically by surgical incision. Then, animals were randomly allocated to four groups (I-untreated controls, II-topically treated with base gel, III-topically treated with 5% gel, IV-topically treated with 10% gel). Results:The results suggest that topical application of Pistacia atlantica oil gels improved reepithelialization with continuous stratum basalis and a mature granulation tissue and adnexa (hair follicles and sweat gland) compared with control and base gel groups. Treatment with 10% oil gel significantly enhanced the tensile strength, ultimate stress, yield strength and stiffness in this group compared with the control and base gel groups at 21 days post injury. The collagen fibers showed a more organized pattern and the tissue alignment was greater as compared to the control and base gel-treated groups at the same stage. Conclusion:The results suggest that topical application of Pistacia atlantica oil gel improved the morphological, biochemical and biomechanical properties of experimentally-induced wound defects in rats.

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“…One study in rats evaluated the role of either vitamin E subfamily by comparing the wound healing properties of ␣ -tocopherol against palm vitamin E extract, which is rich in tocotrienols [26] . Streptozotocin-induced diabetic mice were excision wounded and treated orally with either vitamin E subfamily at 200 mg/kg and compared to controls that were fed olive oil.…”

Section: Vitamin Dmentioning

confidence: 99%

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Fitzmaurice

Sivamani

Isseroff

2011

Skin Pharmacol Physiol

213

144

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Many facets of wound healing under redox control require a delicate balance between oxidative stress and antioxidants. While the normal physiology of wound healing depends on low levels of reactive oxygen species and oxidative stress, an overexposure to oxidative stress leads to impaired wound healing. Antioxidants are postulated to help control wound oxidative stress and thereby accelerate wound healing. Many antioxidants are available over the counter or by prescription, but only one, Medihoney®, has been specifically FDA approved for wound healing. Here we review the existing evidence for the use of antioxidants for wound healing, with a review of the pertinent animal and clinical studies. Natural products and naturally derived antioxidants are becoming more popular, and we specifically review the evidence for the use of naturally derived antioxidants in wound healing. Antioxidant therapy for wound healing is promising, but only few animal studies and even fewer clinical studies are available. Because only few products have undergone FDA approval, the consumer is advised to scrutinize them for purity and contaminants prior to use, and this may require direct contact with the companies that sell them. As a field of science, the use of antioxidants for wound healing is in its infancy, and future studies will better elucidate the role of antioxidants in wound healing.

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Comparative effects of palm vitamin E and α‐tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats

Cited by 61 publications

References 35 publications

Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

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