Comparative Effects of Orange Blossom, Violet, and Marjoram Extracts and Lorazepam on Sleep Deprivation-Induced Anxiety in Mice

Hajjar, Toktam; Arhami, M.; Kakhki, Mohammad Reza Vaezi

doi:10.1007/s11062-019-09787-8

Cited by 2 publications

(1 citation statement)

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“…There is some evidence that marjoram has calming effects; in that, it helps to alleviate negative emotional states such as anxiety (16). A study in mice reported that a marjoram extract effectively reduced the anxiety caused by sleep deprivation (17). Other studies found that the time spent in, and the number of entries into, the open arms in the Elevated Plus Maze test were higher in mice treated with marjoram essential oil compared to controls (18) and that mice exposed to marjoram extract spent more time in the center zone in the Open Field test compared to controls (19).…”

Section: Introductionmentioning

confidence: 99%

Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial

Lee,

Shin,

Lee

et al. 2023

Front. Psychiatry

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BackgroundNurses caring for patients with coronavirus disease 2019 (COVID-19) experience higher psychosocial distress than other healthcare workers, and this can adversely affect the quality of patient care. There is evidence that inhalation of essential oil from marjoram (Origanum majorana L.) has calming effects, suggesting this intervention may help to reduce the stress and anxiety of nurses working in a COVID-19 intensive care unit (ICU). This study aimed to investigate the effect of inhalation of marjoram essential oil at work on the stress and anxiety levels of nurses in a COVID-19 ICU.MethodsNurses (n = 57) working in a single COVID-19 ICU were randomly assigned to inhale 3% marjoram essential oil (marjoram group, n = 29) or almond oil (control group, n = 28) for 2 h while at work. Mean arterial pressure (MAP), heart rate, state anxiety score, and score on a visual analog scale for anxiety (VAS-anxiety) and stress (VAS-stress) were measured before and after the intervention.ResultsThe two groups had similar baseline variables. MAP did not have within-group or between-group differences. Heart rate increased significantly in the marjoram group after the intervention (p = 0.031), but it remained within the normal range and the increase was not clinically meaningful. There was no significant between-group difference in the state-anxiety or VAS-anxiety score after the intervention, but the marjoram group had a significantly lower state-anxiety (p = 0.001) and VAS-anxiety (p = 0.037) score at posttest vs. pretest. The VAS-stress score was significantly lower in the marjoram group at the posttest vs. the pretest (p = 0.026).ConclusionNurses caring for patients in a COVID-19 ICU experience significant stress, and strategies are needed to address this important issue. Inhalation of 3% marjoram essential oil while caring for patients in a COVID-19 ICU may be a simple and effective intervention that reduces perceived stress and anxiety in nurses.Clinical Trial Registration: https://cris.nih.go.kr/, KCT0007543.

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Section: Introductionmentioning

confidence: 99%